全文获取类型
收费全文 | 3339篇 |
免费 | 165篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 22篇 |
儿科学 | 83篇 |
妇产科学 | 137篇 |
基础医学 | 383篇 |
口腔科学 | 44篇 |
临床医学 | 311篇 |
内科学 | 668篇 |
皮肤病学 | 49篇 |
神经病学 | 361篇 |
特种医学 | 132篇 |
外科学 | 542篇 |
综合类 | 8篇 |
预防医学 | 184篇 |
眼科学 | 121篇 |
药学 | 243篇 |
中国医学 | 3篇 |
肿瘤学 | 222篇 |
出版年
2023年 | 26篇 |
2022年 | 58篇 |
2021年 | 90篇 |
2020年 | 44篇 |
2019年 | 62篇 |
2018年 | 60篇 |
2017年 | 59篇 |
2016年 | 70篇 |
2015年 | 70篇 |
2014年 | 76篇 |
2013年 | 128篇 |
2012年 | 202篇 |
2011年 | 236篇 |
2010年 | 127篇 |
2009年 | 118篇 |
2008年 | 178篇 |
2007年 | 171篇 |
2006年 | 159篇 |
2005年 | 183篇 |
2004年 | 142篇 |
2003年 | 143篇 |
2002年 | 122篇 |
2001年 | 112篇 |
2000年 | 102篇 |
1999年 | 105篇 |
1998年 | 38篇 |
1997年 | 25篇 |
1996年 | 31篇 |
1995年 | 30篇 |
1994年 | 19篇 |
1993年 | 19篇 |
1992年 | 63篇 |
1991年 | 49篇 |
1990年 | 43篇 |
1989年 | 52篇 |
1988年 | 32篇 |
1987年 | 42篇 |
1986年 | 42篇 |
1985年 | 24篇 |
1984年 | 16篇 |
1983年 | 13篇 |
1982年 | 14篇 |
1981年 | 8篇 |
1979年 | 9篇 |
1975年 | 11篇 |
1973年 | 7篇 |
1969年 | 10篇 |
1968年 | 14篇 |
1967年 | 8篇 |
1966年 | 9篇 |
排序方式: 共有3513条查询结果,搜索用时 0 毫秒
1.
2.
3.
P A DeSimone C A Martin C B Bacdayan J S Macdonald F J Rizzo J Engelberg 《Hospital practice (Office ed.)》1986,21(1):158, 160, 165-158, 7 passim
4.
Alok Bhargava Matthew Jukes Damaris Ngorosho Charles Khilma Donald A P Bundy 《American journal of human biology》2005,17(3):280-292
This paper models the proximate determinants of school attendance and scores on cognitive and educational achievement tests and on school examinations of over 600 schoolchildren from the Control group of a randomized trial in Tanzania, where children in the Intervention group heavily infected with hookworm and schistosomiasis received treatment. The modeling approach used a random effects framework and incorporated the inter-relationships between school attendance and performance on various tests, controlling for children's health status, socioeconomic variables, grade level, and the educational infrastructure. The empirical results showed the importance of variables such as children's height and hemoglobin concentration for the scores, especially on educational achievement tests that are easy to implement in developing countries. Also, teacher experience and work assignments were significant predictors of the scores on educational achievement tests, and there was some evidence of multiplicative effects of children's heights and work assignments on the test scores. Lastly, some comparisons were made for changes in test scores of treated children in the Intervention group with the untreated children in the Control group. 相似文献
5.
Posterior ischemic optic neuropathy during general surgery 总被引:3,自引:0,他引:3
We examined two patients who awoke with profound bilateral visual loss after operations under general anesthesia. Their fundi, initially normal, later showed bilateral optic atrophy. Neither patient showed other neurologic deficits, although one demonstrated radiologic evidence of a small cerebral infarction in the deep white matter. These patients probably suffered intraoperative infarction of the retrobulbar segments of both optic nerves, producing posterior ischemic optic neuropathy. Profound systemic hypotension may have been a contributing factor in one patient, the use of the pump-oxygenator in the other, and anemia in both. 相似文献
6.
Gazzaniga P. P. Ferroni P. Mina C. Pulcinelli F. M. Rizzo P. A. 《The Italian Journal of Neurological Sciences》1987,8(6):561-566
148 patients with various forms of cerebrovascular disease (CVD) were studied by means of a multiparametric analysis ofin vitro platelet aggregation, based on the following six parameters: ADP and epinephrine primary and secondary aggregation thresholds
and percent maximum aggregation induced by optimal concentrations of ADP and epinephrine. These patients were assigned to
four study groups, according to clinical diagnosis supported by CT scan, of transient ischemic attack and reversible neurological
deficit (TIA-RIND), or completed stroke, in the presence or absence respectively of antiplatelet medical treatment at the
time of the study. A statistically significant increase of thein vitro platelet aggregation was found in 44.4% of the untreated TIA-RIND patients and in 33.9% of the untreated stroke patients.
However this last group showed a higher percentage of very marked hyperaggregation. Differences between the two treated study
groups and controls were not signicant. No difference was found in collagen-and ristocetin-induced aggregation between the
patient groups and the controls.
Sommario 148 pazienti con varie forme di malattia cerebrovascolare, sono stati studiati con analisi multiparametriche dell'aggregazione piastrinica in vitro sulla base dei seguenti sei parametri: le soglie di aggregazione primaria e secondaria e l'aggregazione massima percentuale indotta da ADP ed Epinefrina. Questi pazienti sono stati suddivisi in 4 gruppi di studio in accordo con la diagnosi clinica confortata dai dati della TAC e cioè: TIA, RIND, o rammollimento in presenza o in assenza rispettivamente di un trattamento antiaggregante nel momento dello studio. è stato trovato un aumento statisticamente significativo dell'aggregazione in vitro delle piastrine nel 44.4% dei casi TIA, RIND non trattati e nel 33,9% dei casi di rammollimento non trattati. Quest'ultimo gruppo, però, ha dimostrato una più alta percentuale di iperaggregazione molto marcata. Le differenze tra i 2 gruppi di studio trattati con antiaggreganti e i controlli non erano significative. Inoltre nessuna differenza è stata riscontrata tra i gruppi e i controlli nell'aggregazione indotta da collageno e ristocetina.相似文献
7.
Paolo Martinelli Giovanni Rizzo David Manners Caterina Tonon Fabio Pizza Claudia Testa Cesa Scaglione Bruno Barbiroli Raffaele Lodi 《Movement disorders》2007,22(8):1182-1185
The pathophysiology of essential tremor (ET) is unknown. PET and fMRI studies have revealed bilateral activation and (1)H-MRS studies metabolic abnormalities in the cerebellum and other functionally related brain structures in ET. Diffusion-weighted imaging (DWI) was used to search for evidence of tissue integrity abnormalities in these areas in ET patients and 10 matched controls by calculating water apparent diffusion coefficients (ADCs). Regions of interest included the left and right cerebellum, red nucleus, thalamus, caudate, putamen, pallidum, and frontal white matter. Histograms of ADCs were generated for all pixels in the infratentorial compartment and manually segmented areas corresponding to brainstem, vermis, and cerebellar hemispheres. ADC values were similar in all brain areas in patients and controls. Our study did not detect changes affecting the investigated brain regions in ET patients. These findings argue against major structural damage in the ET brain, although more subtle neurodegenerative changes cannot be ruled out. 相似文献
8.
Blink reflex abnormalities in children with Tourette syndrome 总被引:1,自引:0,他引:1
R. Raffaele L. Rampello I. Vecchio A. Alvano R. Rizzo P. Pavone T. Maci V. Perciavalle 《European journal of neurology》2006,13(8):869-873
Tourette syndrome (TS) is a common disorder which typically occurs during childhood or early adolescence. There is no definitive diagnostic test for TS. The objective of this study was to demonstrate whether neurophysiological abnormalities of the blink reflex can be observed in children with TS. We enrolled 15 children with TS, diagnosed according to DSM IV Diagnostic Criteria, and 15 controls. The blink reflex was elicited by stimulating the supraorbital nerve in order to measure the early response (R1), homolateral and contralateral R2 (late) responses, amplitude of R1 and duration of R2. The mean duration of R2 was significantly longer in TS patients than in the controls ( P < 0.001, Student's t -test). An abnormal pattern of the blink reflex can be, even in childhood, an early neurophysiologic marker of TS, which is not related to the duration of TS or to the age of onset. 相似文献
9.
The following case reports represent two examples using the newly released Dilating Guide Wire. The balloon-wire system is specifically designed to be used as a steerable percutaneous transluminal coronary angioplasty (PTCA) guide wire. It can be utilized as a predilatation device in combination with a standard PTCA dilating balloon or as a free-standing dilatation catheter. As applied to the following situations, predilatation proved to be an effective time- and step-saving approach when confronting severely stenosed coronary artery lesions. 相似文献
10.
Interleukin-2 treatment potentiates induction of oral tolerance in a murine model of autoimmunity. 总被引:6,自引:1,他引:5 下载免费PDF全文
L V Rizzo N E Miller-Rivero C C Chan B Wiggert R B Nussenblatt R R Caspi 《The Journal of clinical investigation》1994,94(4):1668-1672
The present study addresses the feasibility of potentiating oral tolerance by immunomanipulation, using the murine model of experimental autoimmune uveoretinitis (EAU) induced by immunization with the retinal antigen interphotoreceptor retinoid binding protein (IRBP). Three feedings of 0.2 mg IRBP every other day before immunization did not protect against EAU, whereas a similar regimen of five doses was protective. However, supplementing the nonprotective 3x regimen with as little as one injection of 1,000 U of human recombinant interleukin-2 (IL-2) resulted in disease suppression that was equal to that of the protective 5x regimen. The protective effect was maintained across a range of IL-2 doses and times of administration; none of the IL-2 regimens tested resulted in disease enhancement. Peyer's Patch cells of 3x-fed and IL-2-treated mice showed greatly increased production of TGF-beta, IL-4, and IL-10 compared with animals given the nonprotective 3x regimen and to animals given the protective 5x regimen. We propose that IL-2 treatment enhances protection from EAU at least in part by stimulating production of antiinflammatory cytokines by regulatory cells in Payer's Patches. Moreover, the observed lymphokine production patterns suggest that whereas protection induced by the 3x + IL-2 regimen is likely to involve antiinflammatory cytokines, protection induced by the 5x regimen might involve anergy or deletion of the uveitogenic T cells. These results could have practical implications for use of IL-2 as a safe and effective way of potentiating oral tolerance. 相似文献