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排序方式: 共有203条查询结果,搜索用时 15 毫秒
1.
M K Jackson C E Hutton R M Kleyle C E Tomich 《Oral surgery, oral medicine, and oral pathology》1987,63(2):162-166
For a variety of reasons, the past few years have brought about a tremendous emphasis on conditions affecting the temporomandibular joint and associated structures. Although important advances are being made relative to the diagnosis and treatment of these conditions, a myriad of problems remain for the practitioner who tries to sort through the literature or who attends courses in order to determine a means for properly diagnosing and treating these patients. This article attempts to develop correlations between certain clinical and radiographic findings documented by histologic evaluation as a beginning guide to more sound diagnosis. 相似文献
2.
Identification of an ion channel-forming motif in the
primary structure of CFTR, the cystic fibrosis chloride channel. 下载免费PDF全文
M Oblatt-Montal G L Reddy T Iwamoto J M Tomich M Montal 《Proceedings of the National Academy of Sciences of the United States of America》1994,91(4):1495-1499
Synthetic peptides with sequences representingputative transmembrane (M) segments of CFTR (the cystic fibrosis transmembraneconductance regulator) were used as tools to identify the involvement of suchsegments in forming the ionic pore of the CFTR Cl- channel. Peptides withsequences corresponding to M2 and M6 form anion-selective channels afterreconstitution in lipid bilayers. In contrast, peptides with the sequences ofM1, M3, M4, and M5, or peptides of the same amino acid composition as M2 and M6but with scrambled sequences, do not form channels. Conductive heterooligomersof M2 and M6 exhibit a single channel conductance of 8 pS (in 0.15 M KCl) and a95% selectivity for anions over cations, properties that emulate both theconductance and the selectivity of the authentic CFTR channel. Theidentification of sequence-specific motifs that account for key functionalattributes of the CFTR channel suggests that such modules may representfundamental units of function and are plausible constituents of the pore-formingstructure of the CFTR Cl- channel. 相似文献
3.
David C. Thomasma Jonathan Muraskas Patricia A. Marshall Thomas Myers Paul Tomich James A. O'Neill 《The Hastings Center report》1996,26(4):4-12
In June 1993, conjoined twins Amy and Angela Lakeberg became the focus of national attention. They shared a complex six-chambered heart and one liver; only one could survive separation surgery, and even her chances were slim. The medical challenge was great and the ethical challenges were even greater. 相似文献
4.
Wilkinson Karen F. Rush Bob D. Sharma Satish K. Evans David B. Ruwart Mary J. Friis Janice M. Bohanon Michael J. Tomich Paul K. 《Pharmaceutical research》1993,10(4):562-566
We showed previously that a commercially available synthetic tetradecapeptide, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser, produces authentic angiotensin I (Ang I) upon incubation with the HIV-1 protease (S. K. Sharma et al., Anal. Biochem. 198:363, 1991). Therefore, we developed an Ang-I based activity assay for HIV protease inhibitors based on the technology developed earlier (M. J. Ruwart et al., Pharm. Res. 7:407, 1990; S. K. Sharma et al., Anal. Biochem. 186:24, 1990) for tracking renin inhibitors in rat sera. Ditekiren was either extracted from sera with ethyl acetate or assayed after the interfering substances in sera were precipitated with acetonitrile. Purified recombinant HIV-1 protease was added to extracted rat serum and the enzymatic reaction was initiated in the presence of the tetradecapeptide substrate. The inhibition of Ang I production was measured by a commercially available RIA kit. The cleanup methodology also enabled a commercially available Proteinase Scintillation Proximity Assay (SPA, Amersham) to quantify ditekiren in rat serum through the addition of recombinant HIV-1 protease and cleavage of substrate from SPA beads. Results were confirmed by HPLC or by the renin assay for ditekiren, which inhibits both aspartyl proteases. These technologies should prove useful for assessing serum levels of HIV protease inhibitors in rat. 相似文献
5.
This study examined the linkage of posttraumatic growth (PTG) to quality of life (QOL) among individuals newly diagnosed with cancer. Individuals (26 men, 36 women) reported PTG 3 months postdiagnosis (T1) and 3 months later (T2). Cross‐sectional analyses revealed a linear association between PTG and QOL—more PTG was related to worse mental health at T1 (β = ?.28). PTG, however, revealed a quadratic relationship with depressive symptoms at T1 and physical health at T2: Individuals with high or low levels of PTG had fewer depressive symptoms and better QOL than those with moderate levels. Longitudinal analyses revealed a linear association between PTG and QOL; more PTG at T1 predicted better physical health at T2. There were no longitudinal curvilinear associations. Although the linear links of PTG to QOL were contradictory within this study, both of the curvilinear relations, although not robust, confirm previous research. Further analyses differentiated low, medium, and high PTG groups in terms of perceiving cancer as stressful, intrusive thoughts, and coping strategies. Overall, relations of PTG to adjustment may be more complex and dynamic than previously assumed. Clinicians should consider the notion that more growth may sometimes, but not always, be better. 相似文献
6.
Annick Moens C. Janneke van der Woude Mette Julsgaard Evelien Humblet Juliette Sheridan Daniel C. Baumgart Cyrielle Gilletta De Saint-Joseph Stéphane Nancey Jean-François Rahier Peter Bossuyt Anneline Cremer Sophie Dewit Carl Eriksson Frank Hoentjen Thomas Krause Edouard Louis Elisabeth Macken Zoran Milenkovic Jochen Nijs Annelies Posen Anneleen Van Hootegem Wouter Van Moerkercke Séverine Vermeire Ariella Bar-Gil Shitrit Marc Ferrante 《Alimentary pharmacology & therapeutics》2020,51(1):129-138
7.
Melrose RJ Handlers JP Kerpel S Summerlin DJ Tomich CJ;American Academy of Oral Maxillofacial Pathology 《General dentistry》2007,55(5):457-61; quiz 462-3, 488
Biopsy is the gold standard of diagnostic procedures. The American Academy of Oral and Maxillofacial Pathology has stated its position concerning biopsy use in dental practice, believing that using the procedure more frequently will enhance diagnosis and contribute substantially to the quest for more evidence-based practice. Biopsy is a technique within the scope of practice of general dentists. It is vital to understand that biopsy is a tool for the diagnosis of myriad benign and malignant oral conditions. More frequent use of biopsy in dental practice will likely reduce the number of successful lawsuits brought for delay or failure to diagnose. This article offers 10 guidelines to dentists to help assure the success of the procedure. 相似文献
8.
Sarra Smati MD Blandine Tramunt MD Matthieu Wargny MD Cyrielle Caussy MD Bénédicte Gaborit MD Camille Vatier MD Bruno Vergès MD Deborah Ancelle MD Coralie Amadou MD Leila A. Bachir MD Olivier Bourron MD Christine Coffin-Boutreux MD Sara Barraud MD Anne Dorange MD Bénédicte Fremy MD Jean-François Gautier MD Natacha Germain MD Etienne Larger MD Stéphanie Laugier-Robiolle MD Laurent Meyer MD Arnaud Monier MD Isabelle Moura MD Louis Potier MD Nadia Sabbah MD Dominique Seret-Bégué MD Patrice Winiszewski MD Matthieu Pichelin PharmD Pierre-Jean Saulnier MD Samy Hadjadj MD Bertrand Cariou MD Pierre Gourdy MD for the CORONADO investigators 《Diabetes, obesity & metabolism》2021,23(2):391-403
9.
Julien Rohmer Amélie Couteau-Chardon Julie Trichereau Kewin Panel Cyrielle Gesquiere Raouf Ben Abdelali Audrey Bidet Jean-Sébastien Bladé Jean-Michel Cayuela Pascale Cony-Makhoul Vincent Cottin Eric Delabesse Mikaël Ebbo Olivier Fain Pascale Flandrin Lionel Galicier Catherine Godon Nathalie Grardel Aurélien Guffroy Mohamed Hamidou Mathilde Hunault Etienne Lengline Faustine Lhomme Ludovic Lhermitte Irène Machelart Laurent Mauvieux Catherine Mohr Marie-Joelle Mozicconacci Dina Naguib Franck E. Nicolini Jerome Rey Philippe Rousselot Suzanne Tavitian Louis Terriou Guillaume Lefèvre Claude Preudhomme Jean-Emmanuel Kahn Matthieu Groh CEREO GBMHM collaborators 《American journal of hematology》2020,95(11):1314-1323
FIP1L1-PDGFRA-positive myeloid neoplasm with eosinophilia (F/P+ MN-eo) is a rare disease: robust epidemiological data are lacking and reported issues are scarce, of low sample-size and limited follow-up. Imatinib mesylate (IM) is highly efficient but no predictive factor of relapse after discontinuation has yet been identified. One hundred and fifty-one patients with F/P+ MN-eo (143 males; mean age at diagnosis 49 years; mean annual incidence: 0.18 case per million population) were included in this retrospective nationwide study involving all French laboratories who perform the search of F/P fusion gene (study period: 2003-2019). The main organs involved included the spleen (44%), skin (32%), lungs (30%), heart (19%) and central nervous system (9%). Serum vitamin B12 and tryptase levels were elevated in 74/79 (94%) and 45/57 (79%) patients, respectively, and none of the 31 patients initially treated with corticosteroids achieved complete hematologic remission. All 148 (98%) IM-treated patients achieved complete hematologic and molecular (when tested, n = 84) responses. Forty-six patients eventually discontinued IM, among whom 20 (57%) relapsed. In multivariate analysis, time to IM initiation (continuous HR: 1,01 [0.99-1,03]; P = .05) and duration of IM treatment (continuous HR: 0,97 [0,95-0,99]; P = .004) were independent factors of relapse after discontinuation of IM. After a mean follow-up of 80 (56) months, the 1, 5- and 10-year overall survival rates in IM-treated patients were 99%, 95% and 84% respectively. In F/P+ MN-eo, prompt initiation of IM and longer treatment durations may prevent relapses after discontinuation of IM. 相似文献
10.