全文获取类型
收费全文 | 4215篇 |
免费 | 225篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 24篇 |
儿科学 | 70篇 |
妇产科学 | 104篇 |
基础医学 | 424篇 |
口腔科学 | 96篇 |
临床医学 | 311篇 |
内科学 | 1323篇 |
皮肤病学 | 155篇 |
神经病学 | 470篇 |
特种医学 | 114篇 |
外科学 | 670篇 |
综合类 | 17篇 |
预防医学 | 113篇 |
眼科学 | 26篇 |
药学 | 250篇 |
中国医学 | 2篇 |
肿瘤学 | 287篇 |
出版年
2023年 | 18篇 |
2022年 | 26篇 |
2021年 | 83篇 |
2020年 | 72篇 |
2019年 | 66篇 |
2018年 | 92篇 |
2017年 | 77篇 |
2016年 | 81篇 |
2015年 | 108篇 |
2014年 | 157篇 |
2013年 | 181篇 |
2012年 | 252篇 |
2011年 | 262篇 |
2010年 | 159篇 |
2009年 | 152篇 |
2008年 | 238篇 |
2007年 | 275篇 |
2006年 | 237篇 |
2005年 | 269篇 |
2004年 | 223篇 |
2003年 | 192篇 |
2002年 | 192篇 |
2001年 | 107篇 |
2000年 | 94篇 |
1999年 | 91篇 |
1998年 | 43篇 |
1997年 | 33篇 |
1996年 | 37篇 |
1995年 | 23篇 |
1994年 | 28篇 |
1993年 | 23篇 |
1992年 | 71篇 |
1991年 | 35篇 |
1990年 | 41篇 |
1989年 | 54篇 |
1988年 | 46篇 |
1987年 | 45篇 |
1986年 | 35篇 |
1985年 | 39篇 |
1984年 | 15篇 |
1983年 | 21篇 |
1982年 | 15篇 |
1981年 | 20篇 |
1980年 | 12篇 |
1979年 | 14篇 |
1977年 | 9篇 |
1976年 | 9篇 |
1975年 | 9篇 |
1974年 | 18篇 |
1973年 | 10篇 |
排序方式: 共有4456条查询结果,搜索用时 15 毫秒
1.
Alessandro Vatrella Angelantonio Maglio Corrado Pelaia Girolamo Pelaia Carolina Vitale 《Expert opinion on pharmacotherapy》2020,21(12):1505-1515
ABSTRACT
Introduction
‘Critical Asthma Syndrome’ (CAS) is an umbrella term proposed to include several forms of asthma, responsible for acute and life-threatening exacerbations. CAS requires urgent and adequate supportive and pharmacological treatments to prevent serious outcomes. 相似文献2.
Haya Mohammed BSc MChB M. Yousuf Salmasi MRCS Massimo Caputo PhD Gianni D. Angelini PhD Hunaid A. Vohra PhD 《Journal of cardiac surgery》2020,35(6):1209-1219
Background
Limited data exists demonstrating the efficacy of minimally invasive surgery (MIS) compared to median sternotomy (MS) for multiple valvular disease (MVD). This systematic review and meta-analysis aims to compare operative and peri-operative outcomes of MIS vs MS in MVD.Methods
PubMed, Ovid, and Embase were searched from inception until August 2019 for randomized and observational studies comparing MIS and MS in patients with MVD. Clinical outcomes of intra- and postoperative times, reoperation for bleeding and surgical site infection were evaluated.Results
Five observational studies comparing 340 MIS vs 414 MS patients were eligible for qualitative and quantitative review. The quality of evidence assessed using the Newcastle-Ottawa scale was good for all included studies. Meta-analysis demonstrated increased cardiopulmonary bypass time for MIS patients (weighted mean difference [WMD], 0.487; 95% confidence interval [CI], 0.365-0.608; P < .0001). Similarly, aortic cross-clamp time was longer in patients undergoing MIS (WMD, 0.632; 95% CI, 0.509-0.755; P < .0001). No differences were found in operative mortality, reoperation for bleeding, surgical site infection, or hospital stay.Conclusions
MIS for MVD have similar short-term outcomes compared to MS. This adds value to the use of minimally invasive methods for multivalvular surgery, despite conferring longer operative times. However, the paucity in literature and learning curve associated with MIS warrants further evidence, ideally randomized control trials, to support these findings.3.
4.
5.
D. Sforza G. Iaria L. Petagna A. Parente A. Anselmo F. Sergi S. Marzio F. Corrado S. Telli T.M. Manzia G. Tisone 《Transplantation proceedings》2019,51(1):140-142
Background
One daily dose of tacrolimus (QDT) improves adherence in kidney transplant (KT) recipients. A switch from twice-daily tacrolimus (BDT) to QDT showed similar efficacy and safety.Methods
The aim of our study was to demonstrate the long-term efficacy and safety of switching from BDT to QDT in KT recipients. Preliminary results have already been published. Forty-one patients (34 men and 7 women), mean age at KT of 43.9 ± 12.7 years, underwent a 1:1 dose switch from BDT to QDT; the mean time from KT to switch was 36.6 ± 16.1 months. In our study population, 4 patients received a living donor KT and 2 received a second allograft.Results
The mean follow-up was 86.8 ± 13 months from the switch and 126.2 ± 22.3 months from KT. Graft and patient survival rates were 90.2% and 95.1%, respectively. All patients maintained stable renal function during follow-up. During the first 3 months after the switch we observed a significant decrease in tacrolimus blood level (P = .0001). No significant differences were observed regarding tacrolimus dose before and after QDT introduction (P = not significant [NS]). Fourteen patients who stopped steroids under BDT treatment and 16 patients who stopped steroids after the switch are currently steroid-free.Conclusion
Our study showed safety and efficacy in switching from BDT to QDT. After early (<1 year) dose adjustment, tacrolimus blood levels remained stable throughout follow-up. Moreover, QDT represented a valid alternative for patients showing steroid side effects. 相似文献6.
7.
Carmelo Tassi Antonio Angelini Tommaso Beccari Enrico Capodicasa 《Clinical chemistry and laboratory medicine》2006,44(7):843-847
BACKGROUND: The activity and isoenzyme composition of N-acetyl-beta-D-hexosaminidase (EC.3.2.1.52) in seminal plasma of fertile and infertile men have been evaluated. However, no data are available on the isoenzyme content in seminal plasma from patients with secretory azoospermia. METHODS: The activity and isoenzyme composition of seminal plasma from 15 normozoospermic controls and 18 patients with secretory azoospermia were determined by fluorimetric methods. 4-Methylumbelliferil-2-acetamido-2-deoxy-beta-D-glucopyranoside and 4-methylumbelliferil-2-acetamido-2-deoxy-beta-D-glucopyranoside-6-sulfate were used as fluorigenic substrates. Receiver-operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic efficiency of the assays. RESULTS: No significant difference was found in total enzyme activity between the two groups, while isoenzyme A activity was significantly lower (p=0.004) and the ratio between total enzyme activity and isoenzyme A activity was significantly higher (p=0.04) in azoospermic patients compared to controls. The diagnostic efficiency of these evaluations was low (< or =75.7%). CONCLUSIONS: Our findings show that the isoenzyme composition of N-acetyl-beta-D-hexosaminidase in seminal plasma from patients with secretory azoospermia is significantly different from controls, but this difference does not represent a useful marker of secretory azoospermia. The fluorimetric assays are simple and rapid methods for evaluating the isoenzyme composition. 相似文献
8.
9.
Marcos Ribeiro Luciene Angelini Priscila Games Robles-Ribeiro Rafael Stelmach Ubiratan de Paula Santos Mario Terra-Filho 《The Journal of asthma》2007,44(5):371-375
Background. The European Community Respiratory Health Survey (ECRHS) questionnaire was planned to answer questions about the distribution of asthma. Our objective was to determine the cultural equivalence of the ECRHS into the Brazilian-Portuguese language. Methods. We translated the ECRHS according to international criteria. Results. Small cultural adaptations were necessary. Among the 80 participating patients, the Cronbach indices were higher (0.98-1.00) and the Kappa indices varied from 0.77 to 1.00. Conclusion. The study suggests that the Brazilian version of the ECRHS is conceptually equivalent to the original and similarly reliable and may be used in international studies involving Portuguese-speaking respiratory patients. 相似文献
10.
Salvatore Sembronio Alberto Maria Albiero Massimo Robiony Fabio Costa Corrado Toro Massimo Politi 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2007,103(2):e1-e6
Septic arthritis of the temporomandibular joint (TMJ) is infrequently reported. We present a case of septic arthritis of the TMJ following the extraction of the left upper second molar that occurred 1 week before beginning of symptoms. No evident predisposing factors were detected. Arthroscopic diagnosis of septic arthritis, lysis and lavage, and capsular stretch were performed. Cultures taken from the TMJ space grew Streptococcus sp. After 1 month of antimicrobial therapy the patient was asymptomatic and mandibular function was normal. Literature related to septic arthritis of TMJ and its treatment was reviewed. Different surgical procedures are available to treat this condition. Arthroscopy should be preferred as initial treatment on account of the possibility of drainage and accurate lavage under direct visualization of joint space, at the same time allowing confirmation of diagnostic hypotheses. Improving joint mobility with lysis of adhesions and capsular stretch in an early stage of disease may be helpful in stopping the fibrosis process. 相似文献