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排序方式: 共有143条查询结果,搜索用时 15 毫秒
1.
p73 Expression in human normal and tumor tissues: loss of p73alpha expression is associated with tumor progression in bladder cancer. 总被引:1,自引:0,他引:1
2.
Gregoric Kumperscak H. Clausen C. Anagnostopoulos D. Barac Otasevic Z. Boricevic Marsanic V. Burgic M. Como A. Nussbaum L. Pejovic Milovancevic M. Raleva M. Sartorius N. Shahini M. Terziev D. Skokauskas N. 《European child & adolescent psychiatry》2020,29(1):29-39
European Child & Adolescent Psychiatry - There is very limited information available on child and adolescent psychiatry (CAP) training in the Southeast European (SEE) region. The objective of... 相似文献
3.
Multidetector CT with double arterial phase and high–iodine–concentration contrast agent in the detection of hepatocellular carcinoma 总被引:3,自引:0,他引:3
Pozzi Mucelli RM Como G Del Frate C Iuri D Furlan A Al-Grhiw E Bazzocchi M 《La Radiologia medica》2006,111(2):181-191
PURPOSE: The purpose of this study was to determine whether the double arterial phase with multidetector computed tomography MDCT and high-iodine-concentration contrast material (CM) improves identification of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Fifty patients with 111 HCC foci (61 confirmed histologically, 46 confirmed by percutaneous interventional procedures, four confirmed by CT follow-up of at least 6 months) underwent MDCT with a double arterial phase and a portal venous phase after administration of contrast material with a high iodine concentration (400 mgI/ml, 2 ml/kg, 5 ml/s). Two radiologists independently evaluated the images in three distinct reading sessions (early arterial phase (EAP), late arterial phase (LAP) and double arterial phase) to determine presence, number and degree of suspicion of HCC. The sensitivity and the positive predictive value (PPV) were calculated for every reading session. The following statistical evaluations were used: k statistic and McNemar's test. RESULTS: Mean sensitivity and PPV in the detection of HCC were, respectively, 83.8% and 93.5% for EAP, 90.5% and 94.8% for LAP, and 94.1% and 95.1% for the double arterial phase. Sensitivity of the double arterial phase was statistically higher when compared with EAP alone but showed no statistically significant difference when compared with LAP. The k values ndicated moderate-to-excellent interobserver agreement in all reading sessions. CONCLUSIONS: Sensitivity and PPV increase progressively when passing from EAP to LAP to double-arterial-phase images obtained with contrast material with a high iodine concentration. However, the difference in sensitivity between LAP and the double arterial phase was not statistically significant. 相似文献
4.
5.
Peter Graze Robert Sparkes Ronald Como Robert P. Gale 《American journal of hematology》1977,3(2):137-142
A phenotypically normal donor for bone marrow transplantation was found to have a previously unreported karyotype, 46, XY, t(18q+; 22q-), resulting in a Ph′-like chromosome. Identification of the Ph′-like chromosome in cultures of skin fibroblasts, phytohemaglutinin-stimulated peripheral blood cells, and bone marrow cells from the marrow donor, but not in cell cultures from siblings or parents, indicated that it represented an acquired somatic mutation. Demonstration of the Ph′-like chromosome in the marrow graft recipient's blood and bone marrow cells after transplantation provided a unique and definitive marker of engraftment. Hematopoiesis appeared normal in both the donor and recipient after transplantation. This study indicates that a mutation creating a Ph′-like chromosome in hematopoietic cells need not produce hematologic abnormality. Presence of this translocation did not appear to interfere with normal hematopoietic or lymphoid differentiation and replication in the transplant setting. 相似文献
6.
Como JJ Sutton ER McCunn M Dutton RP Johnson SB Aarabi B Scalea TM 《The Journal of trauma》2005,59(4):912-6; discussion 916
BACKGROUND: Patients who sustain cervical spinal cord injury (C-SCI) with neurologic deficit may require a definitive airway and/or prolonged mechanical ventilation. The purpose of this study was to characterize factors associated with a high risk for respiratory failure and/or the need for mechanical ventilation in C-SCI patients. METHODS: Patients with C-SCI and neurologic deficit admitted to a Level I Trauma Center between July 1, 2000 and June 30, 2002 were retrospectively reviewed for demographics, level and completeness of neurologic deficit, need for definitive airway, need for tracheostomy, need for mechanical ventilation at hospital discharge (MVDC), and outcomes. The level and completeness of injury were defined by American Spinal Injury Association standards. RESULTS: One hundred nineteen patients with C-SCI and neurologic deficit were identified over this period. Of these, 45 were identified as complete C-SCI: 12 (27%) patients had levels of C1 to C4; 19 (42%) had a level of C5; and 14 (31%) had levels of C6 and below. There were 37 males and 8 females. There were 36 blunt and 9 penetrating injuries. The average age of these patients was 40 +/- 21, and the average ISS was 45+/-22. Eight of the patients with complete C-SCI died, for a mortality of 18%. Of the 37 survivors, 92% received a definitive airway, 81% received tracheostomy, and 51% required MVDC. All patients with complete injuries at the C5 level and above required a definitive airway and tracheostomy, and 71% of survivors required MVDC. Of the patients with complete injuries of C6 and below, 79% received a definitive airway, 50% required tracheostomy, and 15% of survivors required MVDC. Only 35% of incomplete injuries required a definitive airway, and only 7% required tracheostomy. CONCLUSIONS: The need for definitive airway control, tracheostomy, and ventilator dependence is significant, especially for patients with high complete C-SCI. Based on these results we recommend consideration of early intubation and tracheostomy for patients with complete C-SCI, especially for those with levels of C5 and above. 相似文献
7.
D L Pauls A J Pakstis R Kurlan K K Kidd J F Leckman D J Cohen J R Kidd P Como R Sparkes 《Journal of the American Academy of Child and Adolescent Psychiatry》1990,29(2):195-203
Segregation and linkage analyses were performed with data from a large Tourette's syndrome (TS) multigenerational kindred. Results of segregation analyses were remarkably similar to some reported earlier and suggest that the mode of transmission is consistent with autosomal dominant inheritance. The analyses were done using three diagnostic schemes to specify affected family members (TS only; TS or chronic tics [CT]; and TS, CT or obsessive compulsive disorder [OCD]). The estimates of penetrance for the genotypes AA, Aa and aa (A denotes the susceptibility allele) in the analyses including relatives with TS, CT or OCD were 0.99, 0.99 and 0.00, respectively, for males and 0.70, 0.70 and 0.00 for females. Pairwise linkage analyses with 140 marker loci failed to identify a linked marker. However, approximately 30 percent of the genome was excluded as the site of the hypothesized locus for TS. 相似文献
8.
Electrolytes, BUN, and creatinine are some of the most frequently ordered laboratory tests. The use of these tests in emergency practice has not been studied critically, and few investigations of their use in other disciplines have been performed. A review of the available literature and an analysis of medical problem solving, costs, and complications is presented. Indications based on physiological principles, clinical experience, and limited studies are suggested and areas of future research are outlined. 相似文献
9.
为了解中国农村地区大样本的阿尔茨海默病 (AD)的患病情况 ,我们于 1 999年 1 1~ 1 2月和 2 0 0 0年 4~ 5月在河南林县进行了AD患病率调查。对象 以 1 985年中国医学科学院肿瘤研究所在河南林县四个区征集的所有 40~ 69岁、无食管癌病史 ,并进入随机、双盲的营养干预试验的农村居民为研究对象 ,共 32 90 2名。除外已死亡者 ,本次普查 2 2 4 66名。其中 1 6 488名(73 391 % )入组参与AD的筛查。第一阶段筛查包括测查简易智力状态检查 (MMSE) ,日常生活能力量表 (ADL) ,5 978名(2 6 60 9% )分别因外出、卧床不起、拒绝和失访… 相似文献
10.
De Candia A Como G Passon P Pedace E Bazzocchi M 《Journal of clinical ultrasound : JCU》2002,30(4):236-240
A glomus tympanicum tumor that is associated with a visible retrotympanic mass is the most frequent cause of pulsatile tinnitus. The preoperative diagnostic approach to this lesion includes a meticulous physical examination as well as high-resolution CT, magnetic resonance angiography, and digital angiography, which can also be used for preoperative embolization. We report the use of color transcranial Doppler sonography in the evaluation of glomus tympanicum tumor in a 67-year-old woman with a 3-year history of left tinnitus. An otoscopic examination revealed a reddish pulsatile mass behind an intact tympanic membrane. No lesions were visualized on gray-scale sonography. Contrast-enhanced color transcranial Doppler sonography showed a vascular ovoid mass that measured 2 x 1 x 1 cm; spectral analysis of the lesion revealed arterial flow with a low resistance index. Color transcranial Doppler sonography helped define the dimensions and vascular characteristics of the lesion. 相似文献