全文获取类型
收费全文 | 960篇 |
免费 | 57篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 23篇 |
妇产科学 | 15篇 |
基础医学 | 96篇 |
口腔科学 | 14篇 |
临床医学 | 67篇 |
内科学 | 273篇 |
皮肤病学 | 11篇 |
神经病学 | 79篇 |
特种医学 | 36篇 |
外科学 | 178篇 |
综合类 | 50篇 |
一般理论 | 6篇 |
预防医学 | 87篇 |
眼科学 | 3篇 |
药学 | 52篇 |
肿瘤学 | 27篇 |
出版年
2023年 | 6篇 |
2022年 | 9篇 |
2021年 | 25篇 |
2020年 | 11篇 |
2019年 | 22篇 |
2018年 | 23篇 |
2017年 | 14篇 |
2016年 | 20篇 |
2015年 | 12篇 |
2014年 | 31篇 |
2013年 | 39篇 |
2012年 | 51篇 |
2011年 | 50篇 |
2010年 | 38篇 |
2009年 | 35篇 |
2008年 | 54篇 |
2007年 | 57篇 |
2006年 | 57篇 |
2005年 | 53篇 |
2004年 | 56篇 |
2003年 | 49篇 |
2002年 | 64篇 |
2001年 | 29篇 |
2000年 | 16篇 |
1999年 | 25篇 |
1998年 | 16篇 |
1997年 | 19篇 |
1996年 | 7篇 |
1995年 | 8篇 |
1994年 | 3篇 |
1993年 | 6篇 |
1992年 | 6篇 |
1991年 | 12篇 |
1990年 | 6篇 |
1989年 | 10篇 |
1988年 | 13篇 |
1987年 | 9篇 |
1986年 | 11篇 |
1985年 | 8篇 |
1984年 | 3篇 |
1983年 | 2篇 |
1980年 | 5篇 |
1979年 | 3篇 |
1978年 | 5篇 |
1977年 | 6篇 |
1976年 | 4篇 |
1974年 | 3篇 |
1926年 | 1篇 |
1840年 | 1篇 |
1838年 | 1篇 |
排序方式: 共有1021条查询结果,搜索用时 15 毫秒
1.
2.
Keith J Murphy Andrew G Foley Alan W O'connell Ciaran M Regan 《Neuropsychopharmacology》2006,31(1):90-100
Recent data suggest that Alzheimer's patients who discontinue treatment with cholinesterase inhibitors have a significantly delayed cognitive decline as compared to patients receiving placebo. Such observations suggest cholinesterase inhibitors to provide a disease-modifying effect as well as symptomatic relief and, moreover, that this benefit remains after drug withdrawal. Consistent with this suggestion, we now demonstrate that chronic administration of tacrine, nefiracetam, and deprenyl, drugs that augment cholinergic function, increases the basal frequency of dentate polysialylated neurons in a manner similar to the enhanced neuroplasticity achieved through complex environment rearing. While both drug-treated and complex environment reared animals continue to exhibit memory-associated activation of hippocampal polysialylated neurons, the magnitude is significantly reduced suggesting that such interventions induce a more robust memory pathway that can acquire and consolidate new information more efficiently. This hypothesis is supported by our findings of improved learning behavior and enhanced resistance to cholinergic deficits seen following either intervention. Furthermore, the level of enhancement of basal neuroplastic status achieved by either drug or environmental intervention correlates directly with improved spatial learning ability. As a combination of both interventions failed to further increase basal polysialylated cell frequency, complex environment rearing and chronic drug regimens most likely enhanced cognitive performance by the same mechanism(s). These findings suggest that improved memory-associated synaptic plasticity may be the fundamental mechanism underlying the disease modifying action of drugs such as cholinesterase inhibitors. Moreover, the molecular and cellular events underpinning neuroplastic responses are identified as novel targets in the search for interventive drug strategies for the treatment of neurodegenerative and neuropsychiatric disorders. 相似文献
3.
4.
5.
Aisling E. Courtney Ciaran C. Doherty Brian Herron Mark O. McCarron John K. Connolly J. Ashley Jefferson 《American journal of transplantation》2004,4(7):1204-1207
Myositis is a rare complication following renal transplantation and is most commonly the result of drug-mediated myotoxicity. Other causative disorders include viral infection, electrolyte imbalance and myositis of autoimmune origin. We describe a 60-year-old patient who developed acute polymyositis 4 weeks after a 000 human leukocyte antigen (HLA) mismatch cadaveric renal transplant. Following an uncomplicated transplant course with maintenance triple immunosuppression (prednisolone, mycophenolate mofetil and cyclosporine), the patient presented with severe symmetrical proximal muscle weakness associated with a rise in serum creatine kinase to 46800 U/L. Electromyography confirmed myopathic changes and muscle biopsy demonstrated extensive muscle-fiber necrosis with an inflammatory infiltrate. There were no obviously culpable drugs and viral studies were negative. Prompt initiation of high-dose steroid therapy led to clinical and biochemical recovery. Acute polymyositis may occur following renal transplantation. Potential mechanisms include viral antigen transmission or a localized form of graft vs. host disease. 相似文献
6.
7.
To assess its reliability as a marker of cardiomegaly in elderly patients, we compared a clinical assessment of heart size with that calculated from chest radiography. In 100 hospitalized subjects of median age 78 years, the apex beat was palpable in only 35% and its palpability declined with increasing age. Even when palpable, the apex beat had low specificity (74%) and sensitivity (69%) as a marker of cardiomegaly and its positive predictive value (69%) and negative predictive value (74%) were poor. The clinical assessment of heart size in elderly hospitalized patients should be interpreted with caution. 相似文献
8.
9.
10.
Two successful cases of eliminated atrial flutter and improved clinical status for Fontan patients are presented. An operation combining introduction of an extracardiac conduit for the Fontan connection, to direct all systemic venous blood away from the atrium, and atrial pathway division and cryoablation, is a useful surgical option for failing Fontan patients. 相似文献