全文获取类型
收费全文 | 4077篇 |
免费 | 340篇 |
国内免费 | 136篇 |
专业分类
耳鼻咽喉 | 110篇 |
儿科学 | 110篇 |
妇产科学 | 47篇 |
基础医学 | 498篇 |
口腔科学 | 79篇 |
临床医学 | 396篇 |
内科学 | 646篇 |
皮肤病学 | 32篇 |
神经病学 | 292篇 |
特种医学 | 98篇 |
外科学 | 448篇 |
综合类 | 571篇 |
现状与发展 | 2篇 |
一般理论 | 1篇 |
预防医学 | 288篇 |
眼科学 | 120篇 |
药学 | 357篇 |
中国医学 | 149篇 |
肿瘤学 | 309篇 |
出版年
2024年 | 8篇 |
2023年 | 33篇 |
2022年 | 91篇 |
2021年 | 152篇 |
2020年 | 93篇 |
2019年 | 101篇 |
2018年 | 94篇 |
2017年 | 105篇 |
2016年 | 103篇 |
2015年 | 164篇 |
2014年 | 193篇 |
2013年 | 216篇 |
2012年 | 298篇 |
2011年 | 267篇 |
2010年 | 228篇 |
2009年 | 167篇 |
2008年 | 198篇 |
2007年 | 267篇 |
2006年 | 219篇 |
2005年 | 194篇 |
2004年 | 162篇 |
2003年 | 165篇 |
2002年 | 168篇 |
2001年 | 133篇 |
2000年 | 120篇 |
1999年 | 89篇 |
1998年 | 41篇 |
1997年 | 48篇 |
1996年 | 29篇 |
1995年 | 40篇 |
1994年 | 31篇 |
1993年 | 28篇 |
1992年 | 54篇 |
1991年 | 37篇 |
1990年 | 31篇 |
1989年 | 29篇 |
1988年 | 30篇 |
1987年 | 23篇 |
1986年 | 12篇 |
1985年 | 12篇 |
1983年 | 6篇 |
1982年 | 7篇 |
1981年 | 5篇 |
1980年 | 10篇 |
1979年 | 6篇 |
1978年 | 5篇 |
1976年 | 6篇 |
1975年 | 5篇 |
1970年 | 4篇 |
1968年 | 4篇 |
排序方式: 共有4553条查询结果,搜索用时 15 毫秒
1.
2.
AbstractCadmium (Cd) as environmental pollutant can induce severe damage, particularly to the testis. This study investigated the effects of Caffeic acid phenethyl ester (CAPE) on testicular dysfunction induced by Cd. Adult mice were intraperitoneally injected with cadmium chloride (CdCl2) with different doses of CAPE pretreatment. After CdCl2 injection, body/testis weight ratio decreased, Cd levels accumulated and zinc levels decreased in testis. Furthermore, Cd intoxication caused a significant increase of oxidative stress levels, antioxidant enzymes activities, and glutathione levels. Interestingly, significant improvements were observed after the administration of CAPE. Our results demonstrated the protective effect of CAPE, linking Cd testicular dysfunction to oxidative stress. 相似文献
3.
INTRODUCTION The exact cause of Parkinson disease (PD) has not been known yet[1]. The overwhelming progress had been made in the treatment and pathogenesis of PD in recent 30 years, especially 10 years[2]. But it is still no way now to prevent or postpone… 相似文献
4.
董频 《山东医大基础医学院学报》2006,(4)
目的:运用软硬腭前移的手术方法扩大鼻咽下口,改善因鼻咽部狭小致阻塞性睡眠呼吸暂停综合征患者的呼吸暂停症状。方法:手术切除硬腭后份使其缩短、悬雍垂软腭成形并将软腭拉向前,扩大鼻咽下口。结果:患者术后自觉症状及客观评价疗效满意。结论:软硬腭前移鼻咽下口扩大显著改善鼻咽下口狭小导致的阻塞性睡眠呼吸暂停患者的症状。 相似文献
5.
The clinical and ultrasonographic (US) features of 15 cases of mesenteric or omental cyst are herein described. This series included seven male and eight female patients, whose age ranged from 2–89 years. Correct clinical diagnosis was made in two children only, but preoperative US examination accurately demonstrated the lesion in 11 of 13 patients (85%). These cystic lesions usually had a thin wall, internal septations, and fluid content with sedimentation. Enteric duplication cysts had a relatively thick wall merging with the muscle layer of bowel loop, and multiloculation was noted mainly with cystic lymphangiomas or pseudocysts. The diagnostic and surgical management of these lesions are briefly reviewed and their US appearance is illustrated. 相似文献
6.
7.
8.
Effects of smoking and drinking on excretion of hippuric acid among toluene-exposed workers 总被引:1,自引:1,他引:0
Osamu Inoue Kazunori Seiji Takao Watanabe Haruo Nakatsuka Chui Jin Shi-Jie Liu Masayuki Ikeda 《International archives of occupational and environmental health》1993,64(6):425-430
Summary In order to investigate possible effects of smoking and drinking on the metabolism of toluence in occupational settings, 206 toluene-exposed men (mean age: 31.4 years) in shoemaking, painting, or surface-coating workshops together with 246 nonexposed control men (36.8 years) were studied for the time-weighted average intensities of exposure to toluene, hippuric acid concentration in shift-end urine samples, and the two social habits of smoking and drinking. The mean daily consumptions of cigarettes and ethanol were about 20 pieces and 10 g among smokers and drinkers, respectively. The geometric mean toluene concentration among the exposed subjects was about 20 ppm, with a maximum of 521 ppm. Regression analysis after classification of the subjects by smoking and drinking clearly demonstrated that the two social habits, when combined, markedly reduce the hippuric acid level in the urine of workers exposed to was a significant association between smoking and drinking habits, which hindered separate evaluation of the effects of the two habits on toluene metabolism. Comparison of the present results with the findings reported in the literature, however, suggested that the observed effects may be attributable to smoking rather than to drinking habits. 相似文献
9.
Antiproliferative Activity Against MCF‐7 Breast Cancer Cells by Diamino‐Triazaspirodiene Antifolates
Xiang Ma Renee Ser‐Peng Woon Paul Chi‐Lui Ho Wai‐Keung Chui 《Chemical biology & drug design》2009,74(3):322-326
Two triazaspirodienes, having similar phenoxy propyloxy side chain, were identified as potent mammalian dihydrofolate reductase inhibitors; one having a 6,5‐spiro bicyclic ring system (IC50 = 2.3 nm ) and the other a 6,6‐spiro bicyclic system (IC50 = 6.9 nm ). They also showed more than 50% antiproliferative activity against the MCF‐7 breast cancer cells at 20 μm . This study demonstrated the potential lead of the diamino‐triazaspirodienes in anticancer chemotherapeutical agents’ discovery. 相似文献
10.
Deborah A Cahn-Weiner Sarah Tomaszewski Farias Laura Julian Danielle J Harvey Joel H Kramer Bruce R Reed Dan Mungas Margaret Wetzel Helena Chui 《Journal of the International Neuropsychological Society》2007,13(5):747-757
Impaired ability to conduct daily activities is a diagnostic criterion for dementia and a determinant of healthcare services utilization and caregiver burden. What predicts decline in instrumental activities of daily living (IADLs) is not well understood. This study examined measures of episodic memory, executive function, and MRI brain volumes in relation to baseline IADLs and as predictors of rate of IADL change. Participants were 124 elderly persons with cognitive function between normal and moderate dementia both with and without significant small vessel cerebrovascular disease. Random effects modeling showed that baseline memory and executive function (EXEC) were associated with baseline IADL scores, but only EXEC was independently associated with rate of change in IADLs. Whereas hippocampal and cortical gray matter volumes were significantly associated with baseline IADL scores, only hippocampal volume was associated with IADL change. In a model including cognitive and neuroimaging predictors, only EXEC independently predicted rate of decline in IADL scores. These findings indicate that greater executive dysfunction at initial assessment is associated with more rapid decline in IADLs. Perhaps executive function is particularly important with respect to maintaining IADLs. Alternatively, executive dysfunction may be a sentinel event indicating widespread cortical involvement and poor prognosis. 相似文献