全文获取类型
收费全文 | 3180篇 |
免费 | 178篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 17篇 |
儿科学 | 63篇 |
妇产科学 | 54篇 |
基础医学 | 433篇 |
口腔科学 | 68篇 |
临床医学 | 208篇 |
内科学 | 887篇 |
皮肤病学 | 39篇 |
神经病学 | 240篇 |
特种医学 | 120篇 |
外科学 | 442篇 |
综合类 | 20篇 |
预防医学 | 82篇 |
眼科学 | 42篇 |
药学 | 294篇 |
中国医学 | 13篇 |
肿瘤学 | 362篇 |
出版年
2023年 | 21篇 |
2022年 | 25篇 |
2021年 | 64篇 |
2020年 | 44篇 |
2019年 | 58篇 |
2018年 | 79篇 |
2017年 | 39篇 |
2016年 | 44篇 |
2015年 | 73篇 |
2014年 | 84篇 |
2013年 | 110篇 |
2012年 | 214篇 |
2011年 | 198篇 |
2010年 | 79篇 |
2009年 | 89篇 |
2008年 | 173篇 |
2007年 | 190篇 |
2006年 | 174篇 |
2005年 | 206篇 |
2004年 | 168篇 |
2003年 | 181篇 |
2002年 | 148篇 |
2001年 | 84篇 |
2000年 | 94篇 |
1999年 | 83篇 |
1998年 | 40篇 |
1997年 | 28篇 |
1996年 | 22篇 |
1995年 | 23篇 |
1994年 | 27篇 |
1993年 | 28篇 |
1992年 | 49篇 |
1991年 | 46篇 |
1990年 | 56篇 |
1989年 | 39篇 |
1988年 | 50篇 |
1987年 | 41篇 |
1986年 | 25篇 |
1985年 | 28篇 |
1984年 | 20篇 |
1983年 | 23篇 |
1982年 | 12篇 |
1981年 | 8篇 |
1980年 | 7篇 |
1979年 | 21篇 |
1978年 | 10篇 |
1976年 | 7篇 |
1975年 | 6篇 |
1974年 | 12篇 |
1973年 | 7篇 |
排序方式: 共有3384条查询结果,搜索用时 15 毫秒
1.
Keiko Goto Yutaka Fujiwara Takeshi Isobe Naoko Chayahara Naomi Kiyota Toru Mukohara Yukari Tsubata Takamasa Hotta Kenji Tamura Noboru Yamamoto Hironobu Minami 《Cancer science》2019,110(6):1987-1994
Although dose reduction of S‐1 is recommended for patients with impaired renal function, dose modification for such patients has not been prospectively evaluated. The aim of the present study was to investigate the pharmacokinetic parameters of 5‐fluorouracil, 5‐chloro‐2,4 dihydroxypyridine and oteracil potassium, and to review the recommended dose modification of S‐1 in patients with renal impairment. We classified patients receiving S‐1 into 4 groups according to their renal function, as measured using the Japanese estimated glomerular filtration rate (eGFR) equation. The daily S‐1 dose was adjusted based on the patient's eGFR and body surface area. Blood samples were collected for pharmacokinetic analysis. A total of 33 patients were enrolled and classified into 4 groups as follows: 10 patients in cohort 1 (eGFR ≥ 80 mL/min/1.73 m2), 10 patients in cohort 2 (eGFR = 50‐79 mL/min/1.73 m2), 10 patients in cohort 3 (eGFR = 30‐49 mL/min/1.73 m2), and 3 patients in cohort 4 (eGFR < 30 mL/min/1.73 m2). Those in cohorts 3 and 4 treated with an adjusted dose of S‐1 showed a similar area under the curve for 5‐fluorouracil (941.9 ± 275.6 and 1043.5 ± 224.8 ng/mL, respectively) compared with cohort 2 (1034.9 ± 414.3 ng/mL). Notably, while there was a statistically significant difference between cohort 1 (689.6 ± 208.8 ng/mL) and 2 (P = 0.0474) treated with an equal dose of S‐1, there was no significant difference observed in the toxicity profiles of the cohorts. In conclusion, dose adjustment of S‐1 in patients with impaired renal function using eGFR is appropriate and safe. 相似文献
2.
3.
Hiroto Kinoshita Hitomi Nishioka Aya Ikeda Kyoko Ikoma Yoichi Sameshima Hidehisa Ohi Mizuki Tatsuno Junka Kouyama Chiaki Kawamoto Tomohiro Mitsui Yuko Tamura Yu Hashimoto Masashi Nishio Tsuyoshi Ogashiwa Yusuke Saigusa Shin Maeda Hideaki Kimura Reiko Kunisaki Kazuhiko Koike 《Journal of gastroenterology and hepatology》2019,34(11):1929-1939
4.
5.
N Shigehara H Kakegawa H Miyataka H Matsumoto A Isobe T Satoh 《Photodermatology, photoimmunology & photomedicine》1991,8(6):229-231
Ultraviolet radiation of 8-methoxypsoralen (8-MOP) in the presence of various polyamines resulted in stable photoproducts that were very soluble in water and showed hyaluronidase-activating properties. Among them, the photoproducts obtained from the reaction systems of 8-MOP-spermine and 8-MOP-spermidine markedly activated hyaluronidase. The enzyme activity was not affected by 8-MOP alone and the photoproduct of 8-MOP (8-MOP-P). From these facts, it was suggested that the photoproducts with hyaluronidase-activating properties might play an important role in the onset of 8-MOP-induced photosensitivity. 相似文献
6.
Masao Akagi Shunji Nishimura Kohji Yoshida Takumi Kakinuma Tatsuya Sawamura Hiroshi Munakata Chiaki Hamanishi 《Journal of orthopaedic research》2006,24(8):1782-1790
Mechanical stimulation is known to be an essential factor in the regulation of cartilage metabolism. We tested the hypothesis that expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) can be modulated by cyclic tensile stretch load in chondrocytes. Cyclic loading of repeated stretch stress at 10 cycles per minute with 10 kPa of stress for 6 h induced expression of LOX-1 to 2.6 times control in cultured bovine articular chondrocytes, equivalent to the addition of 10 microg/mL oxidized low density lipoprotein (ox-LDL) (2.4 times control). Application of the cyclic load to the chondrocytes along with 10 microg/mL ox-LDL resulted in synergistically increased LOX-1 expression to 6.3 times control. Individual application of cyclic loading and 10 microg/mL ox-LDL significantly suppressed chondrocytes viability (84.6% +/- 3.4% and 80.9% +/- 3.2% of control at 24 h, respectively; n = 3; p < 0.05) and proteoglycan synthesis [81.0% +/- 7.1% and 85.7% +/- 5.2% of control at 24 h, respectively; p < 0.05 when compared with 94.6% +/- 4.6% for native-LDL (n = 3)]. Cyclic loading and 10 microg/mL ox-LDL synergistically affected cell viability and proteoglycan synthesis, which were significantly suppressed to 45.6% +/- 4.9% and 48.7% +/- 6.7% of control at 24 h, respectively (n = 3; p < 0.01 when compared with individual application of cyclic loading or 10 microg/mL ox-LDL). In this study, we demonstrated synergistic effects of cyclic tensile stretch load and ox-LDL on cell viability and proteoglycan synthesis in chondrocytes, which may be mediated through enhanced expression of LOX-1 and which has important implications in the progression of cartilage degeneration in osteoarthritis. 相似文献
7.
8.
Augmented production of granulocyte-macrophage colony-stimulating factor and alpha/beta interferon in mice inoculated with heat-killed Corynebacterium liquefaciens.
下载免费PDF全文
![点击此处可从《Infection and immunity》网站下载免费的PDF全文](/ch/ext_images/free.gif)
T Yoshida T Hotta K Shimokata M Ichihara K Isobe I Nakashima 《Infection and immunity》1991,59(3):1032-1036
We demonstrated that heat-killed Corynebacterium liquefaciens bacteria, as a known potent host immune activity modulator, stimulate spleen cells to produce granulocyte-macrophage (GM) colony-stimulating factor (CSF) and another CSF with similar activity, as well as alpha/beta interferon, when injected intravenously into mice. Alpha/beta interferon was shown to be produced by C. liquefaciens-activated plastic-G-10 column-adherent cells (A cells) in a thymus-independent manner. In contrast, augmented production of GM-CSF required the action of C. liquefaciens-activated T lymphocytes that collaborated with normal A cells. Non-T spleen cells from C. liquefaciens-stimulated athymic mice, however, produced an alternative CSF that partially replaced GM-CSF. Correspondingly, the numbers of GM-producing CFU developing in cultures of spleen cells from C. liquefaciens-treated euthymic or athymic mice were 10 to 30 times higher than those in cultures of spleen cells from untreated mice. These results suggest that gram-positive rods such as C. liquefaciens activate T and A cells for production of multiple cytokines and that potential cooperative actions of these cytokines underlie the known immunomodulatory action of coryneforms. 相似文献
9.
Yuka Sakazume Makoto Tanaka Itsuo Isobe Rika Tominaga Eiji Nanba Koichi Okamoto 《Clinical neurology》2004,44(8):541-544
We reported a patient with middle-aged onset sialidosis type I. A 52-year-old Japanese man was referred to our hospital because of dysarthria, involuntary movement of his extremities and gait disturbance since the age of 46 years. On admission, neurological examination revealed scanning speech, action myoclonus, cerebellar ataxia and cherry-red spots. Vacuolated lymphocytes were found in peripheral blood. Brain 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography (18F-FDG PET) showed decreased glucose metabolism in the cerebellum. Enzymological analysis using his skin fibroblasts revealed primary deficiency of sialidase activity. Sialidase gene analysis identified compound heterozygotes for base substitusions of 239T-to-C and 649G-to-A, which resulted in amino acid alterations of P80L and V217M, respectively. These mutations have been reported in Japanese sialidosis type II (P80L) and I (V217M). Further studies are required to reveal effects of gene mutations on residual enzyme activities and phenotypes. 相似文献
10.
Einosuke Mizuta Toshihiro Hamada Shin-ichi Taniguchi Masaki Shimoyama Takahiro Nawada Junichiro Miake Yasuhiro Kaetsu Li Peili Kiyosuke Ishiguro Shingo Ishiguro Osamu Igawa Chiaki Shigemasa Ichiro Hisatome 《Hypertension research》2006,29(8):635-638
We report the case of a 67-year-old woman with severe hypertension caused by an extra-adrenal pheochromocytoma. The tumor was detected by 131I metaiodobenzylguanidine scintigraphy and it was found to be small (2 cm ?) by enhanced CT. After the extirpation of the tumor, the blood pressure of the patient immediately normalized. It should be taken into account that a small extra-adrenal pheochromocytoma can be one of the causes of secondary hypertension in elderly patients. Since small extra-adrenal pheochromocytomas are difficult to detect, it is also important to perform suitable examinations to establish the diagnosis. Furthermore, we emphasize the importance of an accurate diagnosis in elderly patients with pheochromocytoma, for they often have less symptomatology and more severe cardiovascular complications due to refractory hypertension than younger patients. 相似文献