全文获取类型
收费全文 | 2362篇 |
免费 | 138篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 212篇 |
妇产科学 | 43篇 |
基础医学 | 278篇 |
口腔科学 | 51篇 |
临床医学 | 193篇 |
内科学 | 560篇 |
皮肤病学 | 42篇 |
神经病学 | 62篇 |
特种医学 | 555篇 |
外科学 | 213篇 |
综合类 | 29篇 |
预防医学 | 66篇 |
眼科学 | 19篇 |
药学 | 66篇 |
中国医学 | 4篇 |
肿瘤学 | 121篇 |
出版年
2022年 | 8篇 |
2021年 | 28篇 |
2020年 | 14篇 |
2019年 | 20篇 |
2018年 | 46篇 |
2017年 | 22篇 |
2016年 | 40篇 |
2015年 | 43篇 |
2014年 | 51篇 |
2013年 | 96篇 |
2012年 | 57篇 |
2011年 | 58篇 |
2010年 | 100篇 |
2009年 | 71篇 |
2008年 | 62篇 |
2007年 | 57篇 |
2006年 | 74篇 |
2005年 | 51篇 |
2004年 | 43篇 |
2003年 | 44篇 |
2002年 | 42篇 |
2001年 | 39篇 |
2000年 | 47篇 |
1999年 | 57篇 |
1998年 | 145篇 |
1997年 | 123篇 |
1996年 | 134篇 |
1995年 | 94篇 |
1994年 | 75篇 |
1993年 | 86篇 |
1992年 | 43篇 |
1991年 | 33篇 |
1990年 | 34篇 |
1989年 | 78篇 |
1988年 | 58篇 |
1987年 | 56篇 |
1986年 | 59篇 |
1985年 | 50篇 |
1984年 | 27篇 |
1983年 | 37篇 |
1982年 | 37篇 |
1981年 | 21篇 |
1980年 | 38篇 |
1979年 | 17篇 |
1978年 | 17篇 |
1977年 | 18篇 |
1976年 | 24篇 |
1975年 | 26篇 |
1969年 | 4篇 |
1966年 | 4篇 |
排序方式: 共有2523条查询结果,搜索用时 250 毫秒
1.
2.
Between January 1977 and December 1982, 66 consecutive patients have been treated for unilateral, rapidly progressing, non metastatic breast cancer. They were divided into three groups: Group A (n = 10): tumor whom volume had increased during the 2 months before diagnosis; Group B (n = 30): inflammatory signs (erythema, skin oedema, elevated local temperature) involving less than one half of the breast; Group C (n = 26): inflammatory signs involving more than one half of the breast. All patients where managed similarly: 3 to 4 courses of chemotherapy (CMF: n = 24; AVCF: n = 42), then loco regional irradiation therapy with cobalt 60, followed by maintenance chemotherapy, only if the first chemotherapy had proved effective (CMF: n = 13; AVCF: n = 27). Nine patients with residual tumor after radiotherapy underwent mastectomy with axillary dissection. The actuarial 5 years survival for the whole group is 29%, and respectively 49%, 38% and 9% for the groups A, B and C. The median disease free intervals are 43, 29 and 12 months respectively. Fifteen prognostic factors likely to influence overall survival or disease free survival were evaluated. With univariate analysis, 8 factors were found to be of individual prognostic value: extent of initial erythema, erythema present after initial chemotherapy, erythema present after radiotherapy, non menopaused status, tumor diameter greater than 10 cms, residual breast tumor (clinical or radiographic) after maintenance chemotherapy, supra clavicular adenopathy (N3). Age at the diagnosis, type of chemotherapy, or performance of a radical mastectomy did not influence the prognosis. Multivariate analysis using the Cox-model isolated 3 factors of bad prognosis: erythema involving the whole breast at initial diagnosis, erythema present at the end of initial chemotherapy, N3. 相似文献
3.
JA HYEON KU CHEOL KWAK SEUNG-JUNE OH EUNSIK LEE SANG EUN LEE JAE-SEUNG PAICK 《International journal of urology》2004,11(7):489-493
BACKGROUND: Our aims in the present study were to estimate the influences of pain and urinary symptoms on quality of life, and to determine which of these two variables has the most predictive power with respect to quality of life in young men with chronic prostatitis-like symptoms. METHODS: Chronic prostatitis-like symptoms were measured by the National Institutes of Health-Chronic Prostatitis Symptom Index. Of the 28,841 men aged 20 years who lived in the study community, 18,495 men (a response rate 64.1%) agreed to participate in the study. A total of 1057 men who complained of symptoms indicative of chronic prostatitis were included in the study. The influences of pain and urinary symptoms on quality of life were determined using logistic regression analysis. The receiver operating characteristic (ROC) curve was used to estimate the predictive ability of each of these variables with respect to quality of life. RESULTS: Results from multivariate analysis showed that both pain and urinary symptoms were associated with an increased likelihood of impaired quality of life, although pain contributed more to a reduced quality of life than urinary symptoms. Relative to men who experienced mild pain, men who experienced moderate pain had a 3.9-fold risk of poor quality of life (odds ratio [OR], 3.87; 95% confidence interval [CI], 2.86-5.23; P < 0.001) and those who experienced severe pain had a 15.7-fold risk of reduced quality of life (OR, 15.68; 95% CI, 6.59-37.35; P < 0.001). Moderate urinary symptoms were associated with a 1.4-fold risk of bother (OR, 1.41; 95% CI, 1.01-1.99; P < 0.001) and severe urinary symptoms were associated with 2.4-fold risk (OR, 2.39; 95% CI, 1.37-4.12; P < 0.001), relative to mild urinary symptoms. Comparison of the effects of pain and urinary symptoms showed that pain severity had the most predictive power for bother, quality of life, and quality-of-life impact. The areas under the ROC curves for bother, quality of life, and quality-of-life impact were 71.3%, 69.3% and 72.5%, respectively. CONCLUSION: Urinary symptoms and pain might be associated with an increased likelihood of impaired quality of life in young men with chronic prostatitis-like symptoms. In addition, our findings suggest that pain severity is the most influential variable for determining quality of life in this population. 相似文献
4.
5.
6.
7.
8.
9.
B Daune M Batt R Hassen-Khodja G Avril J M Gagliardi J Amiel D Chevallier P Le Bas 《The Journal of cardiovascular surgery》1991,32(4):447-450
This prospective study was designed to determine the frequency and natural history of hydroureteronephrosis (HUN) after placement of an aortobifemoral vascular graft. A total of 30 patients were evaluated by the study protocol, which included: pre and postoperative biological kidney function tests, preoperative and early postoperative (14th day) intravenous pyelograms and a late (mean 18th month) urologic examination by renal ultrasonic tomography. Four asymptomatic, early cases of HUN were observed in the 57 ureters examined (7%); all four complications regressed in less than 30 days. No cases of symptomatic early or late HUN were observed in this series. Asymptomatic early HUN was a frequent complication in our series (7%) but its benign course does not justify systematic screening. These asymptomatic complications contrast with the symptomatic cases of early or late HUN reported in the literature which necessitated urologic and vascular investigations. 相似文献
10.