全文获取类型
收费全文 | 4448篇 |
免费 | 257篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 46篇 |
儿科学 | 100篇 |
妇产科学 | 71篇 |
基础医学 | 592篇 |
口腔科学 | 346篇 |
临床医学 | 376篇 |
内科学 | 1044篇 |
皮肤病学 | 103篇 |
神经病学 | 293篇 |
特种医学 | 122篇 |
外科学 | 587篇 |
综合类 | 29篇 |
一般理论 | 4篇 |
预防医学 | 422篇 |
眼科学 | 52篇 |
药学 | 242篇 |
中国医学 | 19篇 |
肿瘤学 | 283篇 |
出版年
2023年 | 34篇 |
2022年 | 93篇 |
2021年 | 159篇 |
2020年 | 98篇 |
2019年 | 127篇 |
2018年 | 162篇 |
2017年 | 101篇 |
2016年 | 116篇 |
2015年 | 153篇 |
2014年 | 178篇 |
2013年 | 233篇 |
2012年 | 384篇 |
2011年 | 359篇 |
2010年 | 208篇 |
2009年 | 182篇 |
2008年 | 297篇 |
2007年 | 281篇 |
2006年 | 243篇 |
2005年 | 222篇 |
2004年 | 207篇 |
2003年 | 164篇 |
2002年 | 151篇 |
2001年 | 47篇 |
2000年 | 50篇 |
1999年 | 45篇 |
1998年 | 29篇 |
1997年 | 16篇 |
1996年 | 24篇 |
1995年 | 17篇 |
1994年 | 13篇 |
1993年 | 14篇 |
1992年 | 26篇 |
1991年 | 26篇 |
1990年 | 24篇 |
1988年 | 13篇 |
1987年 | 23篇 |
1986年 | 11篇 |
1985年 | 20篇 |
1984年 | 21篇 |
1983年 | 12篇 |
1982年 | 13篇 |
1980年 | 10篇 |
1979年 | 8篇 |
1976年 | 7篇 |
1975年 | 9篇 |
1974年 | 7篇 |
1972年 | 9篇 |
1971年 | 8篇 |
1968年 | 9篇 |
1966年 | 9篇 |
排序方式: 共有4731条查询结果,搜索用时 15 毫秒
1.
2.
Marcelo Sato‐Sano Solange Pistori Teixeira Juliano Cordova Vargas Otvio Cesar Carvalho Guimares Baiocchi Milvia Maria Simes e Silva Enokihara Elimar Elias Gomes Mariana Dias Batista 《The Journal of dermatology》2019,46(7):618-621
Eosinophilic dermatosis of hematological malignancy is a paraneoplastic skin eruption associated with chronic lymphocytic leukemia and other B‐cell malignancies. It clinically resembles an insect bite reaction and it can precede the symptoms of the hematological malignancy or be related to a more aggressive course. Different treatments have been proposed, but partial response and recurrence are frequent. Herein, we describe a case of eosinophilic dermatosis associated with mantle cell lymphoma with remission after lenalidomide therapy. 相似文献
3.
Laysa Toschi Martins Henrique Ravanhol Frigeri Caio Cesar Silva de Castro Marcelo Távora Mira 《Experimental dermatology》2020,29(6):535-538
The aetiology of vitiligo has not been fully elucidated, and several hypotheses have been investigated; among them, the most explored assumes an autoimmune basis for the disease. Supporting this hypothesis is the frequent co-occurrence of autoimmune diseases with vitiligo. In addition, various genetic loci associated with vitiligo harbour key immune response genes. Our general hypothesis is that autoimmunity-associated genes participate in the control of vitiligo susceptibility. To investigate this hypothesis, we tested for association between vitiligo and genes CYP27B1, REL, TNFAIP3 and IL2/IL21, all previously related to autoimmune diseases associated with vitiligo. The study was performed using two independent population samples: a family-based discovery set (211 trios) and a replication set (131 cases/119 controls). Statistically significant association with vitiligo was detected between markers of the REL and IL2 gene in the family-based sample. Both association signals were concentrated among patients displaying autoimmune comorbidity and non-segmental vitiligo. Evidence for validation was detected for IL2 marker. Our findings suggest REL and IL2 as new vitiligo susceptibility genes and reinforce the hypothesis of a shared genetic mechanism controlling vitiligo and other autoimmune diseases. 相似文献
4.
5.
M. D. Taylor M. L. de Ceballos S. Rose P. N. Chong P. Jenner C. D. Marsden 《Journal of neural transmission (Vienna, Austria : 1996)》1991,3(2):99-108
Summary Aged common marmosets were treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; 0.5–2.0 mg/kg/week i.p.) for 16 or 24 weeks, observed for a total of 30 weeks and then killed for measurement of biochemical pramaters in basal ganglia. The MPTP treatment induced a marked depletion in dopamine, 3,4-dihydroxyphenylacetic acid and homovanillic acid levels in the caudate nucleus and putamen. In contrast, the concentrations of five neuropeptides: [Met5]-enkephalin, [Leu5]-enkephalin, cholecystokinin, substance P and neurotensin as measured by a combined HPLC/RIA method, remained unaltered in all basal ganglia regions examined. Enkephalin precursor levels, as reflected by cryptic [Met5]-enkephalin content, were increased in the putamen, but not in the caudate nucleus, as a consequence of MPTP administration. Cryptic [Leu5]-enkephalin content remained unchanged in the striatum of MPTP treated marmosets. Overall, these results suggest an increase in striatal [Met5]-enkephalin release following chronic MPTP treatment of aged marmosets. However, the chronic treatment of aged marmosets with MPTP does not reproduce the neuropeptide alterations characteristic of Parkinson's disease. 相似文献
6.
7.
8.
9.
Cesar G. Victora Nubia Muoz Nicholas E. Day Lucio B. Barcelos Debora A. Peccin Noris M. Braga 《International journal of cancer. Journal international du cancer》1987,39(6):710-716
There is a cluster of high-incidence areas of oesophageal cancer in south-eastern South America, including Southern Brazil, Uruguay and parts of Argentina. The present case-control study investigated the hypothesis that this may be due to the drinking of maté, a traditional beverage drunk at a very high temperature, and also studied the role of other known risk factors such as alcohol and tobacco. Cases (171) and age- and sex-matched controls (342) were recruited from hospitals in the State of Rio Grande do Sul in Southern Brazil. The crude odds ratio for daily maté drinkers was 1.92 relative to those drinking less frequently than daily (p = 0.006). Other risk factors included the drinking of cachaça (a sugar cane spirit), smoking, rural residence, low fruit consumption and high intake of meats. After adjustment for these variables through conditional logistic regression, the odds ratio associated with daily maté drinking was reduced to 1.47 (90% CI = 0.87 - 2.50). Although the study failed to provide evidence of a strong association between maté and oesophageal cancer, the cluster of high rates could be explained by relative risks of the magnitude observed. This is due to the fact that approximately 70% of adult males and 50% of females are daily drinkers. In addition, this study revealed that alcohol, tobacco smoking and rural residence are the main risk factors for oesophageal cancer in this population and the fruit consumption confers some degree of protection. 相似文献
10.
A Celis 《Salud pública de México》1991,33(6):585-589
The objective of this work was to identify which preventive factors are involved in drowning. Files of 895 autopsies from 1983 through 1989 by the coroner site office were reviewed. During this seven year period, the annual mortality for drowning was 2.6 per 100,000 population. Males had a higher annual mortality rate (4.2 per 100,000) than females (1.1 per 100,000). The age group between one and four years old had the highest mortality rate (7.6 per 100,000). Deaths tend to cluster around summer. Most of the deaths occurred in house cisterns (19.3%), dams/lakes (16.9%), rivers/canals (14.3%), water wells (12.5%) and swimming pools (10.1%). A third of the deaths occurred at home. The relationship alcohol-drowning starts to stand out in the age group between 10 and 14 years old but get its highest percentage in the age group 35-39 (74%). There are two important findings that is necessary to point out: drowning occurring at home and the relationship between drowning and alcohol ingestion. 相似文献