全文获取类型
收费全文 | 3340篇 |
免费 | 274篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 38篇 |
儿科学 | 119篇 |
妇产科学 | 82篇 |
基础医学 | 471篇 |
口腔科学 | 38篇 |
临床医学 | 364篇 |
内科学 | 743篇 |
皮肤病学 | 36篇 |
神经病学 | 238篇 |
特种医学 | 212篇 |
外国民族医学 | 26篇 |
外科学 | 404篇 |
综合类 | 34篇 |
一般理论 | 1篇 |
预防医学 | 239篇 |
眼科学 | 60篇 |
药学 | 207篇 |
中国医学 | 2篇 |
肿瘤学 | 306篇 |
出版年
2023年 | 20篇 |
2022年 | 37篇 |
2021年 | 74篇 |
2020年 | 37篇 |
2019年 | 88篇 |
2018年 | 100篇 |
2017年 | 74篇 |
2016年 | 81篇 |
2015年 | 80篇 |
2014年 | 115篇 |
2013年 | 157篇 |
2012年 | 220篇 |
2011年 | 232篇 |
2010年 | 132篇 |
2009年 | 117篇 |
2008年 | 198篇 |
2007年 | 179篇 |
2006年 | 178篇 |
2005年 | 160篇 |
2004年 | 155篇 |
2003年 | 141篇 |
2002年 | 109篇 |
2001年 | 74篇 |
2000年 | 81篇 |
1999年 | 70篇 |
1998年 | 29篇 |
1997年 | 29篇 |
1996年 | 23篇 |
1995年 | 28篇 |
1994年 | 17篇 |
1993年 | 23篇 |
1992年 | 56篇 |
1991年 | 43篇 |
1990年 | 34篇 |
1989年 | 48篇 |
1988年 | 22篇 |
1987年 | 41篇 |
1986年 | 45篇 |
1985年 | 24篇 |
1984年 | 20篇 |
1983年 | 18篇 |
1981年 | 11篇 |
1979年 | 15篇 |
1975年 | 13篇 |
1974年 | 20篇 |
1973年 | 13篇 |
1972年 | 17篇 |
1971年 | 13篇 |
1969年 | 17篇 |
1968年 | 12篇 |
排序方式: 共有3620条查询结果,搜索用时 0 毫秒
1.
Background
In meningitis, the cerebrospinal fluid contains high levels of innate immune molecules (e.g. complement) which are essential to ward off the infectious challenge and to promote the infiltration of phagocytes (neutrophils, monocytes). However, epithelial cells of either the ependymal layer, one of the established niche for adult neural stem cells, or of the choroid plexus may be extremely vulnerable to bystander attack by cytotoxic and cytolytic complement components. 相似文献2.
3.
Y. Le Meur M. Büchler A. Thierry S. Caillard F. Villemain S. Lavaud I. Etienne P.-F. Westeel B. H. de Ligny L. Rostaing E. Thervet J. C. Szelag J.-P. Rérolle A. Rousseau G. Touchard P. Marquet 《American journal of transplantation》2007,7(11):2496-2503
Efficacy and safety of mycophenolate mofetil (MMF) may be optimized with individualized doses based on therapeutic monitoring of its active metabolite, mycophenolic acid (MPA). In this 12-month study, 137 renal allograft recipients from 11 French centers receiving basiliximab, cyclosporine A, MMF and corticosteroids were randomized to receive either concentration-controlled doses or fixed-dose MMF. A novel Bayesian estimator of MPA AUC based on three-point sampling was used to individualize doses on posttransplant days 7 and 14 and months 1, 3 and 6. The primary endpoint was treatment failure (death, graft loss, acute rejection and MMF discontinuation). Data from 65 patients/group were analyzed. At month 12, the concentration-controlled group had fewer treatment failures (p = 0.03) and acute rejection episodes (p = 0.01) with no differences in adverse event frequency. The MMF dose was higher in the concentration-controlled group at day 14 (p < 0.0001), month 1 (p < 0.0001) and month 3 (p < 0.01), as were median AUCs on day 14 (33.7 vs. 27.1 mg*h/L; p = 0.0001) and at month 1 (45.0 vs. 30.9 mg*h/L; p < 0.0001). Therapeutic MPA monitoring using a limited sampling strategy can reduce the risk of treatment failure and acute rejection in renal allograft recipients 12 months posttransplant with no increase in adverse events. 相似文献
4.
E Miller A Nicoll S A Rousseau P J Sequeira M H Hambling R W Smithells H Holzel 《British medical journal (Clinical research ed.)》1987,294(6574):737-739
The incidence of congenital rubella was found to be 2.3 times higher in Asian than non-Asian births in England and Wales. This was attributed in part to higher susceptibility to rubella in Asian than non-Asian women, as shown by antenatal serological data from public health laboratories in Leeds, Luton, and Manchester. Examination of the ethnic origin of pregnant women requesting laboratory testing after contact with rubella or rash and of women with laboratory confirmed rubella in pregnancy also suggested that the disease was being underdiagnosed in pregnant Asian women. Failure to prevent congenital rubella by termination of infected pregnancies may therefore contribute to the increased incidence of the syndrome in Asians. Health education programmes about the dangers of rubella in pregnancy and of the need for vaccination can readily be promoted in the Asian community through existing ethnic organisations. Protection of other ethnic minorities likely to be at similar increased risk may require a vaccination programme aimed at national elimination of rubella. 相似文献
5.
Anita Rachlis Jonathan Angel Marianne Harris Richard Lalonde Fiona Smaill Cecile Tremblay Chris Tsoukas Sharon Walmsley 《The Canadian Journal of Infectious Diseases & Medical Microbiology》2006,17(3):155-163
BACKGROUND AND OBJECTIVES: An eight-member group consisting of Canadian infectious disease and immunology specialists and a family physician with significant experience in HIV management was convened to update existing recommendations, specifically intended for use by Canadian HIV-treating physicians, on the appropriate use of enfuvirtide in HIV/AIDS patients with resistance to other antiretroviral drugs. METHODS: Evidence from the literature and expert opinions of the group members formed the basis of the guidelines. Comments on the draft guidelines were obtained from other physicians across Canada with HIV expertise. The final guidelines represent the group's consensus agreement. RESULTS AND CONCLUSIONS: The recommendations were developed to guide physicians in optimal practices in patient selection for enfuvirtide treatment and subsequent patient management. The issues considered include positive predictors of response to enfuvirtide, stage of disease, optimization of the background regimen, early indicators of enfuvirtide response, and patient education and support. 相似文献
6.
Christiane Knoop Philippe Thiry Franck Saint-Marcoux Annick Rousseau Pierre Marquet Marc Estenne 《American journal of transplantation》2005,5(6):1477-1482
In cystic fibrosis (CF), absorption of tacrolimus through the gastrointestinal tract may be impaired due to fat malabsorption. The aim of this pilot study was to compare tacrolimus pharmacokinetics and inter- and intrasubject variability of exposure in stable lung transplant recipients with and without CF, and to determine the best single-time predictors of exposure. The study included 11 lung transplant recipients with CF and 11 without CF who received tacrolimus twice daily. Blood samples were obtained predose and at 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 8 and 12 h postdose on 3 separate days within 1 week. Tacrolimus pharmacokinetics and inter- and intrasubject variability of exposure were similar in the two groups, though exposure-per-milligram-dose was approximately 50% lower in CF patients. Tacrolimus trough concentration did not accurately predict the area under the concentration curve (AUC(0-12)), but the concentration measured 3 h postdose (C(3)) was tightly correlated with the AUC(0-12) in both CF (r(2)= 0.86) and non-CF (r(2)= 0.92) patients. In summary, patients with CF have a higher tacrolimus oral clearance, but nonsignificant differences in short-term inter- and intrasubject variability of exposure compared to patients without CF. C(3) is tightly correlated with AUC(0-12) in lung transplant recipients with and without CF. 相似文献
7.
8.
9.
D Johnstone M Limacher M Rousseau C S Liang L Ekelund M Herman D Stewart M Guillotte G Bjerken W Gaasch 《The American journal of cardiology》1992,70(9):894-900
The Studies of Left Ventricular Dysfunction (SOLVD) trials were designed to evaluate the effects of enalapril on long-term mortality in patients with severe left ventricular (LV) dysfunction. Patients with LV ejection fractions less than or equal to 0.35 and symptoms of congestive heart failure (CHF) were enrolled in the treatment trial, whereas those with no history of overt CHF and taking no treatment directed for LV dysfunction were enrolled in the prevention trial. The baseline clinical characteristics of SOLVD patients were compared to characterize differences between patients in these 2 separate but concurrent trials. From over 70,000 patients screened with LV dysfunction, 4,228 patients were enrolled in the prevention trial and 2,569 patients in the treatment trial. Ischemic heart disease was the primary cause of LV dysfunction in both prevention (83%) and treatment (71%) trial patients. Prior myocardial infarction was present in 80% of the prevention and 66% of the treatment trial patients (p less than 0.001). In the prevention trial, infarction was recent (less than or equal to 6 months) in 27% patients and remote (greater than 6 months) in 57% patients. Treatment trial patients had proportionately more women (20 vs 13%; p less than 0.001) and non-Caucasians (20 vs 14%; p less than 0.001), as well as the coexisting risk factors of hypertension (42 vs 37%; p less than 0.001) and diabetes (26 vs 15%; p less than 0.001) than did prevention trial patients. Clinical characteristics of patients in both trials were influenced by the gender and race of enrolled patients. Similarly, coronary artery bypass surgery was performed less often in women and non-Caucasians.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
10.