全文获取类型
收费全文 | 17641篇 |
免费 | 1000篇 |
国内免费 | 77篇 |
专业分类
耳鼻咽喉 | 138篇 |
儿科学 | 437篇 |
妇产科学 | 486篇 |
基础医学 | 2413篇 |
口腔科学 | 332篇 |
临床医学 | 1672篇 |
内科学 | 4067篇 |
皮肤病学 | 471篇 |
神经病学 | 1514篇 |
特种医学 | 306篇 |
外科学 | 1766篇 |
综合类 | 83篇 |
一般理论 | 13篇 |
预防医学 | 1889篇 |
眼科学 | 420篇 |
药学 | 1208篇 |
中国医学 | 73篇 |
肿瘤学 | 1430篇 |
出版年
2024年 | 13篇 |
2023年 | 129篇 |
2022年 | 263篇 |
2021年 | 604篇 |
2020年 | 325篇 |
2019年 | 521篇 |
2018年 | 565篇 |
2017年 | 376篇 |
2016年 | 376篇 |
2015年 | 504篇 |
2014年 | 714篇 |
2013年 | 945篇 |
2012年 | 1394篇 |
2011年 | 1562篇 |
2010年 | 848篇 |
2009年 | 661篇 |
2008年 | 1208篇 |
2007年 | 1213篇 |
2006年 | 1138篇 |
2005年 | 1109篇 |
2004年 | 971篇 |
2003年 | 899篇 |
2002年 | 825篇 |
2001年 | 142篇 |
2000年 | 121篇 |
1999年 | 132篇 |
1998年 | 145篇 |
1997年 | 119篇 |
1996年 | 78篇 |
1995年 | 83篇 |
1994年 | 70篇 |
1993年 | 50篇 |
1992年 | 70篇 |
1991年 | 57篇 |
1990年 | 46篇 |
1989年 | 53篇 |
1988年 | 49篇 |
1987年 | 31篇 |
1986年 | 35篇 |
1985年 | 38篇 |
1984年 | 27篇 |
1983年 | 24篇 |
1982年 | 25篇 |
1981年 | 17篇 |
1980年 | 20篇 |
1979年 | 11篇 |
1978年 | 12篇 |
1977年 | 11篇 |
1976年 | 11篇 |
1974年 | 14篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
María del Carmen Azorín Samper Marta Hernandorena Gonzlez Alberto Ibez Arias Sandra Díaz Sierra Marta Bertolo Domínguez Flix Checa Ayet 《The breast journal》2020,26(2):252-254
Breast pseudoaneurysms after a core needle biopsy are a rare complication with a low incidence. However, it is important to be aware of the possibility of complications that require treatment. 相似文献
2.
Primary cutaneous anaplastic large cell lymphomas with 6p25.3 rearrangement exhibit particular histological features 下载免费PDF全文
3.
Ignasi Esteban Carmen Pastor-Quiones Lorena Usero Montserrat Plana Felipe García Lorna Leal 《Viruses》2021,13(3)
Over 36 million people worldwide are infected with HIV. Antiretroviral therapy (ART) has proven to be highly effective to prevent HIV-1 transmission, clinical progression and death. Despite this success, the number of HIV-1 infected individuals continues increasing and ART should be taken for life. Therefore, there are two main priorities: the development of preventive vaccines to protect from HIV acquisition and achieve an efficient control of HIV infection in the absence of ART (functional cure). In this sense, in the last few years, there has been a broad interest in new and innovative approaches such as mRNA-based vaccines. RNA-based immunogens represent a promising alternative to conventional vaccines because of their high potency, capacity for rapid development and potential for low-cost manufacture and safe administration. Some mRNA-based vaccines platforms against infectious diseases have demonstrated encouraging results in animal models and humans. However, their application is still limited because the instability and inefficient in vivo delivery of mRNA. Immunogens, design, immunogenicity, chemical modifications on the molecule or the vaccine delivery methods are all crucial interventions for improvement. In this review we, will present the current knowledge and challenges in this research field. mRNA vaccines hold great promises as part of a combined strategy, for achieving HIV functional cure. 相似文献
4.
5.
Enrique Luengo Izaskun Buendia Cristina Fernndez‐Mendívil Paula Trigo‐Alonso Pilar Negredo Patrycja Michalska Borja Hernndez‐García Cristina Snchez‐Ramos Juan A. Bernal Tsuneya Ikezu Rafael Len Manuela G. Lpez 《Journal of pineal research》2019,67(1)
Alterations in autophagy are increasingly being recognized in the pathogenesis of proteinopathies like Alzheimer's disease (AD). This study was conducted to evaluate whether melatonin treatment could provide beneficial effects in an Alzheimer model related to tauopathy by improving the autophagic flux and, thereby, prevent cognitive decline. The injection of AAV‐hTauP301L viral vectors and treatment/injection with okadaic acid were used to achieve mouse and human ex vivo, and in vivo tau‐related models. Melatonin (10 μmol/L) impeded oxidative stress, tau hyperphosphorylation, and cell death by restoring autophagy flux in the ex vivo models. In the in vivo studies, intracerebroventricular injection of AAV‐hTauP301L increased oxidative stress, neuroinflammation, and tau hyperphosphorylation in the hippocampus 7 days after the injection, without inducing cognitive impairment; however, when animals were maintained for 28 days, cognitive decline was apparent. Interestingly, late melatonin treatment (10 mg/kg), starting once the alterations mentioned above were established (from day 7 to day 28), reduced oxidative stress, neuroinflammation, tau hyperphosphorylation, and caspase‐3 activation; these observations correlated with restoration of the autophagy flux and memory improvement. This study highlights the importance of autophagic dysregulation in tauopathy and how administration of pharmacological doses of melatonin, once tauopathy is initiated, can restore the autophagy flux, reduce proteinopathy, and prevent cognitive decline. We therefore propose exogenous melatonin supplementation or the development of melatonin derivatives to improve autophagy flux for the treatment of proteinopathies like AD. 相似文献
6.
7.
José A. Lorente Pablo Cardinal-Fernández Diego Muñoz Fernando Frutos-Vivar Arnaud W. Thille Carlos Jaramillo Aida Ballén-Barragán José M. Rodríguez Oscar Peñuelas Guillermo Ortiz José Blanco Bruno Valle Pinheiro Nicolás Nin María del Carmen Marin Andrés Esteban Taylor B. Thompson 《Intensive care medicine》2015,41(11):1921-1930
8.
Is it possible to make a diagnosis of raw,heated, and baked egg allergy in children using cutoffs? A systematic review 下载免费PDF全文
9.
Lesley A. Inker Morgan E. Grams Andrew S. Levey Josef Coresh Massimo Cirillo John F. Collins Ron T. Gansevoort Orlando M. Gutierrez Takayuki Hamano Gunnar H. Heine Shizukiyo Ishikawa Sun Ha Jee Florian Kronenberg Martin J. Landray Katsuyuki Miura Girish N. Nadkarni Carmen A. Peralta Dietrich Rothenbacher Mark Woodward 《American journal of kidney diseases》2019,73(2):206-217
10.
María Cabrerizo Gloria Trallero María José Pena Amaia Cilla Gregoria Megias Carmen Mu?oz-Almagro Eva Del Amo Diana Roda Ana Isabel Mensalvas Antonio Moreno-Docón Juan García-Costa Nuria Rabella Manuel Ome?aca María Pilar Romero Sara Sanbonmatsu-Gámez Mercedes Pérez-Ruiz María José Santos-Mu?oz Cristina Calvo And the study group of “Enterovirus parechovirus infections in children under ?years-old Spain” PI- 《European journal of pediatrics》2015,174(11):1511-1516