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1.
An in-vitro study of the interactions between intravenous induction agents and the calcium antagonists verapamil and nifedipine 总被引:1,自引:0,他引:1
Thiopentone, propofol and etomidate inhibit the contractions of the rat isolated atria and portal vein. The actions of thiopentone and propofol summate with those of verapamil and nifedipine. Verapamil potentiates the action of etomidate on both preparations. The depressant actions of thiopentone and propofol on the portal vein are associated with a reduced response to calcium. Etomidate does not reduce the response to calcium in this preparation. 相似文献
2.
J. G. Miller P. Bunting D. A. R. Burd J. D. Edwards 《Burns : journal of the International Society for Burn Injuries》1994,20(6):542-546
We examined the case records of 50 consecutive patients with major cutaneous burns who required early mechanical ventilation. In 22 patients full haemodynamic and respiratory data were available within 24 h of their injury. Unexpectedly the haemodynamic and oxygen transport patterns of survivors and non-survivors were essentially similar although pulmonary artery occlusion pressure measurements and estimations of net fluid input suggest that non-survivors were relatively underresuscitated compared with survivors. Both groups showed inadequate oxygen utilization in the early stages of their injury despite normal (or above normal) levels of oxygen delivery. Invasive monitoring could possibly help this subgroup of burns patients. 相似文献
3.
The electrical activity of single neurones in the hypothalamic arcuate and supraoptic nuclei was recorded in urethane-anaesthetized rats. Stimulus pulses applied to the supraoptic nucleus antidromically activated 3 out of 41 cells recorded in the ipsilateral arcuate nucleus, confirming that there is a projection from the arcuate nucleus to the region of the supraoptic nucleus. Stimulation of the arcuate nucleus inhibited 17 out of 19 continuously firing (putative oxytocin) supraoptic neurones. Inhibition was followed by a marked post-stimulus excitation in 12 cells. The responses were not abolished by i.v. injection of the opioid antagonist naloxone. Thus at least part of the input to the magnocellular oxytocin system that arises from or passes through the arcuate nucleus, is not mediated by opioid peptides. 相似文献
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Macintyre et al. [Macintyre, S., Hunt, K., Sweeting, H., 1996. Gender differences in health: are things really as simple as they seem? Social Science and Medicine 42, 617-624] stated that the "whole topic of gender differences in health warrants periodic re-examination". In this paper we begin by presenting an overview of the main sources of national data that are available for monitoring patterns and trends in health by gender. We then give examples of a selection of indicators which contribute to the debate on the nature of differences between men and women in terms of their mortality. morbidity and health service utilisation. We conclude by urging readers to make more use of these sources of data to throw further light on the reasons for the differences and similarities in women's and men's experiences of health. 相似文献
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Bunting BA 《Drug intelligence & clinical pharmacy》1978,12(8):475-481
An example is given of the implementation of clinical pharmacy service program in a community hospital. The need for establishing an efficient drug distribution system is discussed, and the feasibility of utilizing clinically motivated staff pharmacists is presented. A method of limiting the number of patients admitted to the clinical pharmacy service program is also given. 相似文献
8.
Muscle biopsies were obtained in sixteen cases of rheumatoid arthritis in an effort to repeat the work of Freund3 and his collaborators. As controls, biopsies were obtained in fifteen other patients among whom were included cases of osteoarthritis, rheumatic fever, gonococcal arthritis, and “non-specific infectious” arthritis; similar studies were made in twenty-three routine autopsy cases.Muscle lesions were found in thirteen of the sixteen cases of rheumatoid arthritis and in two of the four control cases of “non-specific infectious” arthritis. With the exception of one patient with osteoarthritis who had a history suggestive of rheumatoid arthritis these lesions were absent from all other controls. Our results would give no indication of any fundamental difference between the “atrophic” and the “non-specific infectious” forms of rheumatoid arthritis.The lesions consisted of focal accumulations of lymphocytes and macrophages and occasional plasma cells and eosinophils occurring either in perivascular locations in the perimysium or in the endomysium between the individual muscle fibers. Hyalinization, vacuolization, loss of striations and atrophy of muscle fibers were found frequently in association with these cellular foci in the above group, while in the controls similar degenerative changes occurred without any cellular reaction.These cellular accumulations would appear to be further evidence of the systemic nature of rheumatoid arthritis. Although they have not been found in all cases of this disease, their presence has been limited almost exclusively to rheumatoid arthritis. Their nature is unknown, and their direct relationship to the duration or activity of the disease is as yet undetermined. 相似文献
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