全文获取类型
收费全文 | 13627篇 |
免费 | 904篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 312篇 |
儿科学 | 836篇 |
妇产科学 | 367篇 |
基础医学 | 1263篇 |
口腔科学 | 927篇 |
临床医学 | 1122篇 |
内科学 | 2565篇 |
皮肤病学 | 395篇 |
神经病学 | 1005篇 |
特种医学 | 480篇 |
外科学 | 2625篇 |
综合类 | 94篇 |
一般理论 | 1篇 |
预防医学 | 822篇 |
眼科学 | 353篇 |
药学 | 778篇 |
中国医学 | 46篇 |
肿瘤学 | 558篇 |
出版年
2023年 | 200篇 |
2022年 | 165篇 |
2021年 | 359篇 |
2020年 | 280篇 |
2019年 | 336篇 |
2018年 | 579篇 |
2017年 | 429篇 |
2016年 | 561篇 |
2015年 | 578篇 |
2014年 | 657篇 |
2013年 | 1139篇 |
2012年 | 754篇 |
2011年 | 775篇 |
2010年 | 641篇 |
2009年 | 408篇 |
2008年 | 433篇 |
2007年 | 421篇 |
2006年 | 578篇 |
2005年 | 516篇 |
2004年 | 458篇 |
2003年 | 423篇 |
2002年 | 414篇 |
2001年 | 411篇 |
2000年 | 350篇 |
1999年 | 346篇 |
1998年 | 203篇 |
1997年 | 154篇 |
1996年 | 171篇 |
1995年 | 121篇 |
1994年 | 112篇 |
1993年 | 106篇 |
1992年 | 130篇 |
1991年 | 102篇 |
1990年 | 94篇 |
1989年 | 79篇 |
1988年 | 67篇 |
1987年 | 56篇 |
1986年 | 55篇 |
1985年 | 59篇 |
1984年 | 56篇 |
1983年 | 43篇 |
1982年 | 35篇 |
1981年 | 42篇 |
1980年 | 39篇 |
1979年 | 48篇 |
1977年 | 41篇 |
1974年 | 39篇 |
1973年 | 41篇 |
1971年 | 34篇 |
1968年 | 34篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
2.
Increased arterial stiffness in young normotensive patients with Turner syndrome: associations with vascular biomarkers 下载免费PDF全文
3.
Summary Split or full thickness eyelid defects resulting from tumor destruction or surgical excision present a dilemma for plastic and reconstructive surgeons. Full thickness eyelid replacement requires composite grafting of the skin, together with tarsal support of its substitute and mucosa. The flap described by Fricke in 1829 was used for reconstruction of anterior lamella in six lower eyelid defects. In three of our cases chondromucosal grafts taken from nasal septum were utilized for posterior lamella repair. The results have been satisfactory from a functional and cosmetic standpoint. 相似文献
4.
Compromise of immune function in obstructive jaundice. 总被引:5,自引:0,他引:5
5.
Å. Öst P. Lindström B. Christensson H. Gyllenhammar L. Engstedt 《European journal of haematology》1984,33(2):160-170
A consecutive series of patients (1978–1981) comprising all patients with acute leukaemia from a population of 475000 inhabitants was reviewed. Thus, 94 patients were diagnosed as having acute leukaemia. No patients were lost from follow-up. The incidence figures of ALL and AML differed significantly from those of Sweden as a whole. 9 patients were < 15 years old. The median age of adult patients was 64 years, 60.8% being ≥ 60 years old. Of adult patients with AML, 20% had a preleukaemic history (chronic myeloproliferative disorders, myelodysplastic syndromes and others). None of 6 patients with leukaemia as a metamorphosis of a chronic myeloproliferative disorder achieved a complete remission. The overall remission rate of the remaining adult patients was 25%. Treated patients, 15–39 years old, with AML without any preleukaemic history, had a complete remission rate of 80% compared to 12% for patients ≥ 60 years old with the same diagnosis. Of 60 patients with ‘primary’ AML, 14 were not treated, mainly because of advanced age and complicating diseases. Most of these patients died within a week of admission. 相似文献
6.
E Maquarre C Artus Z Gadhoum C Jasmin F Smadja-Joffe J Robert-Lézénès 《Leukemia》2005,19(12):2296-2303
We have recently reported that ligation of the CD44 cell surface antigen with A3D8 monoclonal antibody (mAb) triggers incomplete differentiation and apoptosis of the acute promyelocytic leukemia (APL)-derived NB4 cells. The present study characterizes the mechanisms underlying the apoptotic effect of A3D8 in NB4 cells. We show that A3D8 induces activation of both initiator caspase-8 and -9 and effector caspase-3 and -7 but only inhibition of caspase-3/7 and caspase-8 reduces A3D8-induced apoptosis. Moreover, A3D8 induces mitochondrial alterations (decrease in mitochondrial membrane potential DeltaPsi m and cytochrome c release), which are reduced by caspase-8 inhibitor, suggesting that caspase-8 is primarily involved in A3D8-induced apoptosis of NB4 cells. However, the apoptotic process is independent of TNF-family death receptor signalling. Interestingly, the general serine protease inhibitor 4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF) decreases A3D8-induced apoptosis and when combined with general caspase inhibitor displays an additive effect resulting in complete prevention of apoptosis. These results suggest that both caspase-dependent and serine protease-dependent pathways contribute to A3D8-induced apoptosis. Finally, A3D8 induces apoptosis in all-trans-retinoic acid-resistant NB4-derived cells and in APL primary blasts, characterizing the A3D8 anti-CD44 mAb as a novel class of apoptosis-inducing agent in APL. 相似文献
7.
8.
Abstract – Traumatic dental injuries often occur to the teeth and their supporting tissues and they are the main reasons for emergency visit to a dental clinic. Management of a fracture depends on its position and the extent of root involvement. Horizontal root fractures are not seen frequently and the treatment consists of reduction and long‐term rigid fixation of the coronal segment. The present case demonstrates the successful management of two horizontally fractured maxillary central incisors with a follow‐up period of 9 months. 相似文献
9.
10.
Selda Sarikaya Bektas Acikg?z Ismail Hakki Tekk?k Y Yücel Güngen 《Journal of clinical neuroscience》2007,14(9):901-904
We report a 24-year-old woman with an intramedullary conus ependymoma associated with holocord syringohydromyelia and syringobulbia. The tumor was removed and surgery for decompression of the syringohydromyelia was not considered at the first operation. In the follow-up examinations, MRI showed significant and steady improvement of syringohydromyelia. Symptoms associated with syringohydromyelia also disappeared. The cause of syringohydromyelia accompanying intradural spinal cord tumors appears to be either direct blockade of the central canal or secondary interruption of the central canal flow by compression of the perimedullary cerebrospinal fluid flow. As removal of the mass often corrects both these likely causes of the syringohydromyelia, no additional treatment for the drainage of the hydromyelia cavity syrinx is usually necessary. 相似文献