全文获取类型
收费全文 | 443篇 |
免费 | 7篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 22篇 |
妇产科学 | 1篇 |
基础医学 | 43篇 |
口腔科学 | 2篇 |
临床医学 | 25篇 |
内科学 | 69篇 |
皮肤病学 | 6篇 |
神经病学 | 58篇 |
特种医学 | 72篇 |
外科学 | 27篇 |
综合类 | 50篇 |
预防医学 | 11篇 |
药学 | 54篇 |
中国医学 | 1篇 |
肿瘤学 | 15篇 |
出版年
2022年 | 1篇 |
2021年 | 3篇 |
2020年 | 1篇 |
2019年 | 3篇 |
2018年 | 1篇 |
2017年 | 2篇 |
2016年 | 2篇 |
2014年 | 7篇 |
2013年 | 4篇 |
2012年 | 12篇 |
2011年 | 12篇 |
2010年 | 12篇 |
2009年 | 7篇 |
2008年 | 19篇 |
2007年 | 19篇 |
2006年 | 16篇 |
2005年 | 15篇 |
2004年 | 18篇 |
2003年 | 14篇 |
2002年 | 5篇 |
2001年 | 6篇 |
2000年 | 3篇 |
1999年 | 12篇 |
1998年 | 33篇 |
1997年 | 25篇 |
1996年 | 24篇 |
1995年 | 11篇 |
1994年 | 18篇 |
1993年 | 18篇 |
1992年 | 14篇 |
1991年 | 13篇 |
1990年 | 16篇 |
1989年 | 16篇 |
1988年 | 18篇 |
1987年 | 9篇 |
1986年 | 9篇 |
1985年 | 8篇 |
1984年 | 3篇 |
1983年 | 4篇 |
1982年 | 6篇 |
1981年 | 6篇 |
1980年 | 6篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1976年 | 2篇 |
1975年 | 1篇 |
1972年 | 1篇 |
排序方式: 共有457条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
M Kaplan HJ Vreman C Hammerman C Leiter B Rudensky MG MacDonald DK Stevenson 《Acta paediatrica (Oslo, Norway : 1992)》1998,87(4):455-457
The incidence (%) of hyperbilirubinemia (serum bilirubin ≥257 μmol/l) was similar in neonates with a combination of ABO incompatibility and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency (45%), with ABO incompatibility (54%) or G-6-PD deficiency (37%), alone (ns). Carboxyhemoglobin values, corrected for inspired CO, were similarly elevated in all three groups (0.87 ± 0.32%, 0.82 ± 0.29%, 0.76 ± 0.18%, respectively, ns), but correlated with bilirubin only in those with ABO incompatibility alone. ABO-incompatible/G-6-PD-deficient neonates, compared with those with either condition alone, are not at increased risk for hemolysis or hyperbilirubinemia. 相似文献
6.
7.
The firing of a proportion of neurons in the in vivo perirhinal cortex, a brain region involved in object recognition memory, has recently been shown to be synchronized with hippocampal theta activity. The purpose of the present study was to determine whether neurons located in perirhinal cortex have intrinsic properties that might encourage their participation in theta activity. To these ends, current clamp recordings were made from 98 neurons located in layer III/V of the in vitro rat perirhinal cortex. The intrinsic properties of these neurons were investigated, and a subset of 61 neurons were tested for the presence of membrane potential oscillations at threshold levels of depolarization. Thirty-nine percent of these neurons displayed a theta-frequency membrane potential oscillation (MPO; mean frequency = 8.6 Hz). When depolarized past spike threshold, these neurons tended to fire in clusters, with a within-cluster interspike interval close to the peak to peak interval of the MPOs. Neurons that did not generate MPOs generated nonaccomodating action potential trains with a frequency that spanned the theta range. Biocytin staining indicated that MPOs could be generated in cells with both pyramidal and nonpyramidal morphology. These findings demonstrate that a large proportion of perirhinal neurons exhibit intrinsic properties that could assist in the entrainment and synchronization of theta-frequency oscillations. These properties may enhance the communication of information between the perirhinal cortex, entorhinal cortex, and hippocampus. 相似文献
8.
A new design for an inexpensive and reliable subminiature microdrive for unit recording in the freely moving animal is presented. The 'Scribe' microdrive is (a) of a small size and low weight, (b) allows for precise advancement of the electrodes, (c) permits stable unit recordings over time, (d) is simple to install, and (e) is economical to construct. These advantages are a result of its simple, single screw-based drive system and the ready availability of component parts. The Scribe microdrive is a small diameter device suitable for multi-site, multi-electrode applications. 相似文献
9.
Anorexia nervosa (AN) is a serious life-threatening illness that typically has its onset during the adolescent years. Evidence regarding the optimal treatment of AN in children and teenagers is growing; however, much remains unknown. Although current treatment approaches vary in Canada and elsewhere, the evidence to date indicates that family-based treatment (FBT) is the most effective treatment for children and teenagers with AN. A key component of the FBT model is that the parents are given the responsibility to return their child to physical health and ensure full weight restoration. An understanding of the basic principles and philosophy underlying FBT allows the physician to initiate elements of this evidence-based intervention to young patients with AN and their families. 相似文献
10.
Role of extracellular adenosine triphosphate in the cytotoxic T- lymphocyte-mediated lysis of antigen presenting cells 总被引:4,自引:0,他引:4
The lysis of antigen presenting cells (APCs) by cytotoxic T lymphocytes (CTLs) may be one mechanism whereby an immune response is downregulated by Staphylococcus superantigens. Disappearance of monocytes/macrophages from staphylococcal enterotoxin A (SEA)-activated peripheral blood mononuclear cell (PBMC) cultures, but not from control PBMC cultures was seen by flow cytometry. Recently, adenosine triphosphate (ATP) has been described as an effector molecule in CTL-mediated lysis of some murine tumor target cells. We have also shown that ATP caused the lysis of human macrophages, and that treatment of cells with interferon gamma (IFN gamma) rendered macrophages significantly more sensitive to ATP than untreated cells. To show that this purine nucleotide may play a role in modulating the immune system, we generated human CTLs that were stimulated with SEA, and used them as effector cells against SEA-pulsed autologous macrophages. CTLs were found to specifically lyse SEA-pulsed macrophages, while control, unpulsed, macrophages were unaffected. The addition of hexokinase, an enzyme that hydrolyzes ATP, significantly abrogated the killing of SEA-pulsed cells during the assay. In examining the mechanism of cytotoxicity, electron microscopy showed that macrophages incubated with both ATP and CTLs underwent necrosis, rather than apoptosis. From these results, it is suggested that ATP is released from CTLs during antigen presentation, and that IFN gamma- activated macrophages, which are inherently more sensitive to this mediator, are readily lysed and therefore removed from circulation, thus downregulating an immune response. 相似文献