排序方式： 共有39条查询结果，搜索用时 15 毫秒
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Bonnefoy Pierre-Benoît Prevot Nathalie Mehdipoor Ghazaleh Sanchez Alicia Lima Jorge Font Llorenç Gil-Díaz Aída Llamas Pilar Aibar Jesús Bikdeli Behnood Bertoletti Laurent Monreal Manuel 《Journal of thrombosis and thrombolysis》2022,53(4):829-840
Journal of Thrombosis and Thrombolysis - Ventilation/perfusion (V/Q) imaging and computed tomography pulmonary angiography (CTPA) are common tools for acute pulmonary embolism (PE) diagnosis.... 相似文献
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Wassim M. Haddad Vijaysekhar Chellaboina Behnood Gholami 《Optimal control applications & methods.》2009,30(1):27-45
Linear matrix inequalities (LMIs) provide a powerful design framework for linear control problems. In this paper, we use LMIs to develop ??2 (sub)optimal estimators and controllers for nonnegative dynamical systems. Specifically, we formulate a series of generalized eigenvalue problems subject to a set of LMI constraints for designing ??2 suboptimal estimators, static controllers, and dynamic controllers for nonnegative dynamical systems. The resulting ??2 suboptimal controllers guarantee that the closed‐loop plant system states remain in the nonnegative orthant of the state space. Finally, a numerical example is provided to demonstrate the efficacy of the proposed approach. Copyright © 2008 John Wiley & Sons, Ltd. 相似文献
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Benjamin Brenner Behnood Bikdeli Inna Tzoran Olga Madridano Raquel López-Reyes José María Suriñach Ángeles Blanco-Molina Antonella Tufano Juan José López Núñez Javier Trujillo-Santos Manuel Monreal 《The American journal of medicine》2018,131(9):1095-1103
Background
Venous thromboembolism is common in patients with malignancies, affecting up to 10% of this patient population. The association between arterial ischemic events and venous thromboembolism also has been established. However, the influence of arterial ischemic events on outcomes in cancer patients with venous thromboembolism has not been fully determined.Methods
The current study analyzed clinical characteristics, time course, risk factors, incidence and severity of venous thromboembolism recurrences, arterial ischemic events and major bleeding in 5717 patients with active cancer and venous thromboembolism recruited into RIETE (multi-center prospective registry of patients with objectively confirmed venous thromboembolism).Results
During the anticoagulation course (median 7.3 months), 499 (8.7%) patients developed venous thromboembolism recurrences, 63 (1.1%) developed arterial events, and 346 (6.1%) suffered from major bleeding. Overall, major bleeding and arterial events appeared earlier (median 35 and 36 days, respectively) than venous thromboembolism recurrences (median 97 days). Thirty-day mortality rates after each event were: 20% after recurrent pulmonary embolism, 13% after recurrent deep vein thrombosis, 41% after major bleeding, 40% after myocardial infarction, 64% after ischemic stroke, and 83% after lower limb amputation. Bleeding was the leading cause of death (67 fatal bleeds), whereas cumulative mortality due to arterial ischemic events (n?=?27) was similar to that related to pulmonary embolism recurrences (n?=?26).Conclusions
In this study, arterial ischemic events and major bleeding appeared early after venous thromboembolism in patients with active cancer and were among frequent causes of their deaths. The risk and severity of arterial events need to be considered in this clinical setting. 相似文献9.
Agnesa Avanesian Behnood Khodayari Jeffery S. Felgner Mahtab Jafari 《Biogerontology》2010,11(1):45-52
The discovery of life extension in Caenorhabditis elegans treated with anticonvulsant medications has raised the question whether these drugs are prospective anti-aging candidate
compounds. The impact of these compounds on neural modulation suggests that they might influence the chronic diseases of aging
as well. Lamotrigine is a commonly used anticonvulsant with a relatively good adverse-effects profile. In this study, we evaluated
the interaction between the impacts of lamotrigine on mortality rate, lifespan, metabolic rate and locomotion. It has been
proposed in a wide range of animal models that there is an inverse relationship between longevity, metabolic rate, and locomotion.
We hypothesized that the survival benefits displayed by this compound would be associated with deleterious effects on health
span, such as depression of locomotion. Using Drosophila as our model system, we found that lamotrigine decreased mortality and increased lifespan in parallel with a reduction in
locomotor activity and a trend towards metabolic rate depression. Our findings underscore the view that assessing health span
is critical in the pursuit of useful anti-aging compounds. 相似文献
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