全文获取类型
收费全文 | 1284篇 |
免费 | 74篇 |
国内免费 | 14篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 71篇 |
妇产科学 | 22篇 |
基础医学 | 206篇 |
口腔科学 | 22篇 |
临床医学 | 140篇 |
内科学 | 285篇 |
皮肤病学 | 18篇 |
神经病学 | 93篇 |
特种医学 | 112篇 |
外科学 | 101篇 |
综合类 | 15篇 |
预防医学 | 118篇 |
眼科学 | 1篇 |
药学 | 70篇 |
中国医学 | 1篇 |
肿瘤学 | 94篇 |
出版年
2022年 | 8篇 |
2021年 | 34篇 |
2020年 | 15篇 |
2019年 | 16篇 |
2018年 | 20篇 |
2017年 | 20篇 |
2016年 | 23篇 |
2015年 | 38篇 |
2014年 | 44篇 |
2013年 | 55篇 |
2012年 | 62篇 |
2011年 | 59篇 |
2010年 | 50篇 |
2009年 | 41篇 |
2008年 | 52篇 |
2007年 | 56篇 |
2006年 | 43篇 |
2005年 | 40篇 |
2004年 | 31篇 |
2003年 | 28篇 |
2002年 | 26篇 |
2001年 | 33篇 |
2000年 | 36篇 |
1999年 | 40篇 |
1998年 | 34篇 |
1997年 | 32篇 |
1996年 | 42篇 |
1995年 | 28篇 |
1994年 | 18篇 |
1993年 | 15篇 |
1992年 | 28篇 |
1991年 | 17篇 |
1990年 | 27篇 |
1989年 | 28篇 |
1988年 | 27篇 |
1987年 | 27篇 |
1986年 | 19篇 |
1985年 | 17篇 |
1984年 | 11篇 |
1983年 | 14篇 |
1982年 | 9篇 |
1981年 | 8篇 |
1980年 | 9篇 |
1979年 | 6篇 |
1978年 | 7篇 |
1976年 | 6篇 |
1931年 | 4篇 |
1926年 | 6篇 |
1925年 | 6篇 |
1919年 | 4篇 |
排序方式: 共有1372条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
S Ben Becher J el Mabrouk A Debbiche A Hammou N Ghram S Makni T Boudhina 《Archives fran?aises de pédiatrie》1992,49(9):799-802
BACKGROUND. Schwartz-Jampel syndrome is a rare disorder inherited as an autosomal recessive trait and characterized by growth retardation, multiple skeletal abnormalities, myotonia-like muscle disorders and unusual facies. CASE REPORTS. Case n. 1: A boy, aged 3 years 4 months, was admitted for acute respiratory disease. His main abnormalities included rigid facial expression, blepharophimosis, puckered lips, short neck, pectus carinatum, acetabular dysplasia with coxa vara, platyspondyly and marked growth retardation. There was a continuous muscle fiber activity at rest, with abnormal discharges originating in the muscle component of the neuromuscular junction. Blood investigations revealed low values of IgA. The child died at 4 years. Case n. 2: The sister of case n. 1 was examined at 14 months of age. She presented milder facies abnormalities, difficulties of gait because of stiff hips, muscular hypertrophy, coxa vara and growth retardation. X-rays showed skeletal abnormalities and the electromyogram was similar to those of her brother. She had dislocation of her optic lens. CONCLUSION. These 2 sibs have the characteristic manifestations of Schwartz-Jampel syndrome. Parental consanguinity was also present. The IgA deficiency observed in case n. 1 and the lens dislocation in case n. 2 have both been occasionally reported in this syndrome. 相似文献
5.
6.
7.
Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis. 总被引:12,自引:0,他引:12
Philip Washbourne Peter M Thompson Mario Carta Edmar T Costa James R Mathews Guillermina Lopez-Benditó Zoltán Molnár Mark W Becher C Fernando Valenzuela L Donald Partridge Michael C Wilson 《Nature neuroscience》2002,5(1):19-26
Axon outgrowth during development and neurotransmitter release depends on exocytotic mechanisms, although what protein machinery is common to or differentiates these processes remains unclear. Here we show that the neural t-SNARE (target-membrane-associated-soluble N-ethylmaleimide fusion protein attachment protein (SNAP) receptor) SNAP-25 is not required for nerve growth or stimulus-independent neurotransmitter release, but is essential for evoked synaptic transmission at neuromuscular junctions and central synapses. These results demonstrate that the development of neurotransmission requires the recruitment of a specialized SNARE core complex to meet the demands of regulated exocytosis. 相似文献
8.
A 54-year old man presented with multiple pulmonary emboli and an incidental finding of a huge left ventricular thrombus. Transthoracic echo images demonstrated a globally dilated heart with very poor left ventricular function. It was elected to manage the patient medically, and he was commenced on warfarin therapy, resulting in completed resolution of the thrombus over 10 weeks. No underlying cause was found and he did not experience any further embolic events. This illustrates a rare case of a large ventricular thrombus in a patient with no underlying risk factors. 相似文献
9.
10.
Human ovarian granulosa cells and follicular fluid indices: the relationship to oocyte maturity and fertilization in vitro 总被引:1,自引:0,他引:1
The study investigates the correlation between oocyte maturity and
fertilization and a variety of hormonal parameters in follicular fluid and
ovarian granulosa cells. A methodology for purification of granulosa cells
from contaminating blood cells is also established. A total of 63
follicular aspirates were collected at oocyte retrieval from 30 women
superovulated using the long luteinizing hormone- releasing hormone (LHRH
analogue)/human menopausal gonadotrophin regimen. Oestradiol, progesterone,
testosterone and human chorionic gonadotrophin (HCG) were quantified in
follicular fluid and granulosa cells were immunostained for human chorionic
gonadotrophin. Immunopurification of granulosa cells from contaminating
blood cells was performed. HCG in follicular fluid was significantly high
in follicles yielding immature (grade 3) oocytes (P=0.002); there was no
correlation with fertilization. Aspirates from follicles containing mature
(grade 1) oocytes and oocytes that subsequently fertilized had
significantly more granulosa cells immunobound to HCG (P < 0.001,
P=0.02). Moreover, the immunomagnetic purification technique provided
>98% pure population of granulosa cells. The data demonstrate that HCG
in follicular fluid and on granulosa cells may help to predict oocyte
maturity and fertilization. Furthermore, immunomagnetic beads provide a
reliable procedure for the purification of ovarian granulosa cells.
相似文献