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排序方式: 共有392条查询结果,搜索用时 62 毫秒
1.
Soft tissue reactions resulting from biodegradable polylactide implants to bone have not been adequately examined during their 3-year degradation period. An osteotomy was performed on the medial femoral condyle of 36 sheep and secured by either three poly-L-DL-lactide pins (70/30) (Polypin) or three composite pins [10% beta-tricalcium phosphate (beta-TCP) (90/10)]. A histological examination was performed on the synovial membrane and lymph nodes after 3, 18 and 36 months. After 18 months two non-specific, minor reactions of the synovial membrane were observed in the composite pin group. In both groups different reactions of both inguinal lymph nodes were observed. These had no statistical relevance and could not be clearly attributed to the implants. Due to the slow degradation process of biodegradable polylactide implants, there is no clinically relevant inflammation of either joint or lymph nodes. The addition of 10% beta-TCP did not result in any significant enhancement. 相似文献
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Brandhagen DJ Fairbanks VF Baldus WP Smith CI Kruckeberg KE Schaid DJ Thibodeau SN 《The American journal of gastroenterology》2000,95(10):2910-2914
OBJECTIVE: The HFE gene contains two mutant alleles; C282Y and H63D. The C282Y mutation occurs in 55-100% of patients with hereditary hemochromatosis. The aim of our study was to re-examine the frequencies of the C282Y and H63D mutations in patients with mild and marked iron overload and in normal subjects. METHODS: A total of 82 patients with iron overload were included in this study and had hepatic iron index determination and/or quantitation of iron stores by phlebotomy. The control group consisted of 81 healthy blood donors. HFE mutation analysis was performed on leukocyte DNA using PCR-amplified genomic DNA. RESULTS: Of patients with iron overload, 70/82 (85%) were homozygous for C282Y versus 2/81 (2.5%) in the control population. Four patients had no HFE mutations despite significant iron overload, including a sister and brother (brother not included in the study group) with hepatic iron concentrations >500 micromoles/g dry weight. CONCLUSIONS: In all, 85% of our patients with iron overload were C282Y homozygotes, although a few had no HFE gene mutations. Pooled data and analysis of chromosomes considered to be at risk for H63D indicate that H63D is associated with iron overload. 相似文献
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Acute myeloid leukemia with complex karyotypes and abnormal chromosome 21: Amplification discloses overexpression of APP, ETS2, and ERG genes 总被引:5,自引:0,他引:5
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D Buchheidt C Baust H Skladny J Ritter T Suedhoff M Baldus W Seifarth C Leib-Moesch R Hehlmann 《Clinical infectious diseases》2001,33(4):428-435
Bronchoalveolar lavage (BAL) samples from 67 patients who were at high risk for invasive aspergillosis were examined using a recently developed 2-step polymerase chain reaction (PCR) that detects =10 fg of Aspergillus DNA in blood and BAL samples in vitro. Thirteen of these patients had PCR and diagnostic results positive for Aspergillus infection. Four patients with possible invasive aspergillosis also had positive PCR results, and the remaining 50 had negative PCR results. In addition, 907 blood samples from 218 high-risk patients were screened. Thirty-three patients with positive PCR results had invasive aspergillosis; 148 patients had PCR and diagnostic results that were negative, and 34 patients with positive PCR results had nonconclusive clinical data. Both blood and BAL testing were performed for 45 patients. All 8 patients with proven invasive aspergillosis showed concordance of positive PCR results. Our data suggest that this PCR method has possible clinical value for confirming and improving the diagnosis of invasive aspergillosis in high-risk patients. 相似文献
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Adler Christoph Onur Oezguer A. Braumann Simon Gramespacher Hannes Bittner Stefan Falk Steffen Fink Gereon R. Baldus Stephan Warnke Clemens 《Journal of neurology》2022,269(3):1530-1537
Journal of Neurology - To test if the early kinetics of neurofilament light (NFL) in blood adds to the absolute values of NFL in the prediction of outcome, and to evaluate if NFL can discriminate... 相似文献
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Natalia Krawczyk Rowena Rwer Martin Anlauf Caja Muntanjohl Stephan Ernst Baldus Monika Neumann Maggie Banys-Paluchowski Sabine Otten Katharina Luczak Eugen Ruckhberle Svjetlana Mohrmann Jürgen Hoffmann Thomas Kaleta Bernadette Jaeger Irene Esposito Tanja Fehm 《Geburtshilfe und Frauenheilkunde》2022,82(1):68
Introduction Invasive breast cancer with neuroendocrine differentiation is a rare subtype of breast malignancy. Due to frequent changes in the definition of these lesions, the correct diagnosis, estimation of exact prevalence, and clinical behaviour of this entity may be challenging. The aim of this study was to evaluate the prevalence, clinical features, and outcomes in a large cohort of patients with breast cancer with neuroendocrine differentiation. Patients Twenty-seven cases of breast cancer with neuroendocrine differentiation have been included in this analysis. Twenty-one cases were identified by systematic immunohistochemical re-evaluation of 465 breast cancer specimens using the neuroendocrine markers chromogranin A and synaptophysin, resulting in a prevalence of 4.5%. A further six cases were identified by a review of clinical records. Results Median age at the time of diagnosis was 61 years. 70% of patients had T2 – 4 tumors and 37% were node-positive. The most common immunohistochemical subtype was HR-positive/HER2-negative (85%). 93% were positive for synaptophysin and 48% for chromogranin A. Somatostatin receptor type 2A status was positive in 12 of 24 analyzed tumors (50%). Neuroendocrine-specific treatment with somatostatin analogues was administered in two patients. The 5-year survival rate was 70%. Conclusions Breast cancer with neuroendocrine differentiation is mostly HR-positive/HER2-negative and the diagnosis is made at a higher TNM stage than in patients with conventional invasive breast carcinoma. Moreover, breast cancer with neuroendocrine differentiation was found to be associated with impaired prognosis in several retrospective trials. Due to somatostatin receptor 2A expression, somatostatin receptor-based imaging can be used and somatostatin receptor-targeted therapy can be offered in selected cases. Key words: neuroendocrine neoplasia of the breast, invasive breast cancer with neuroendocrine differentiation, neuroendocrine breast cancer, neuroendocrine markers, somatostatin receptor 2A 相似文献
10.
p53 Expression in Gastric Cancer (Clinicopathological Correlation and Prognostic Significance) 总被引:5,自引:0,他引:5
S.P. Monig S. Eidt T.K. Zirbes D. Stippel S.E. Baldus H. Pichlmaier 《Digestive diseases and sciences》1997,42(12):2463-2467
For evaluation of the prognostic relevance ofp53 expression in gastric cancer, theimmunohistochemical tissue status of 133 primary gastriccancer patients was investigated for p53 expression andthe association between p53 tissue status andclinicopathological parameters was analyzed. P53immunoreactivity was detected in the nuclei of cancercells in 35 cases (26.3%). The nuclear p53immunoreaction was closely associated with tumor location, lymph nodemetastasis, and curability. Tumors with positive p53stain reactions frequently metastasized to lymph nodes(metastatic rate: 91.4%) in contrast to tumors with negative p53 stain reactivity (71.4%, P =0.021). Immunohistochemical analysis of primary gastriccancer appears to be an accurate and simple method ofscreening for p53 expression. In combination with common prognostic parameters, determination of p53tissue status might help to detect prognosticallyunfavorable subgroups of gastric cancerpatients. 相似文献