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排序方式: 共有374条查询结果,搜索用时 31 毫秒
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Yamaoka Mai Yoshida Mahoko Nakashima Ayumu Doi Shigehiro Naito Takayuki Masaki Takao 《Clinical and experimental nephrology》2022,26(11):1111-1118
Clinical and Experimental Nephrology - The association between N-terminal pro-brain natriuretic peptide (NT-proBNP) and stroke in Japanese hemodialysis (HD) outpatients is unclear. Therefore, in... 相似文献
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T Abu-Nema K Ayyash L Berntman Y Matani G H Sigurdsson I Francis C Hellekant 《Circulatory shock》1988,24(1):55-62
Two groups (n = 10 in each) of adult sheep were exposed to hemorrhagic shock resulting in mean arterial pressure (MAP) below 25 mmHg for 10 min. Following that, group A received crystalloids (8% of body wt) during one hr together with supraceliac intraaortic balloon tamponade during the first 30 min, while group B (controls) received crystalloids only. The central circulation was rapidly restored in group A, as indicated by increased MAP and increased systemic vascular resistance (SVR). After deflation of the balloon MAP dropped to the same value as in the control group, while cardiac index increased gradually with volume replacement and was significantly higher at the end of the resuscitation period (60 min) than in the control group (P less than 0.05). Despite a more rapid restoration of central hemodynamics in group A, lactic acidosis was more severe, acute renal failure and neurological complications more frequent, and mortality higher than in the control group. It was concluded that continuous supraceliac aortic occlusion for 30 min had deleterious effects on organs dependent on aortic blood flow distal to the aortic tamponade and may contribute to the development of multiple organ failure after resuscitation from hemorrhagic shock. Further studies are needed to evaluate the effects of intermittent intraaortic balloon tamponade in hemorrhagic shock. 相似文献
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Morita Y Ujike H Tanaka Y Uchida N Nomura A Ohtani K Kishimoto M Morio A Imamura T Sakai A Inada T Harano M Komiyama T Yamada M Sekine Y Iwata N Iyo M Sora I Ozaki N Kuroda S 《Neuroscience letters》2005,376(3):182-187
Genetic contributions to the etiology of substance abuse and dependence are topics of major interest. Acute and chronic cannabis use can produce drug-induced psychosis resembling schizophrenia and worsen positive symptoms of schizophrenia. The endocannabinoid system is one of the most important neural signaling pathways implicated in substance abuse and dependence. The fatty acid amide hydrolase (FAAH) is a primary catabolic enzyme of endocannabinoids. To clarify a possible involvement of FAAH in the etiology of methamphetamine dependence/psychosis or schizophrenia, we examined the genetic association of a nonsynonymous polymorphism of the FAAH gene (Pro129Thr) by a case-control study. We found no significant association in allele and genotype frequencies of the polymorphism with either disorder. Because the Pro129Thr polymorphism reduces enzyme instability, it is unlikely that dysfunction of FAAH and enhanced endocannabinoid system induce susceptibility to either methamphetamine dependence/psychosis or schizophrenia. 相似文献
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Cytokines in patients with lung cancer 总被引:5,自引:0,他引:5
Matanić D Beg-Zec Z Stojanović D Matakorić N Flego V Milevoj-Ribić F 《Scandinavian journal of immunology》2003,57(2):173-178
Lung cancer is one of the most common malignant diseases and is amongst the leading causes of death. Cell-mediated immune response and cytokines could play an important role in antitumour immunity. The aim of the study was to evaluate the cytokines', tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and IL-6, releasing capacity in patients with lung carcinoma and benign lung disease. A group of 41 patients were tested for the production of TNF-alpha, IL-1beta and IL-6 in bronchoalveolar lavage (BAL) and blood. The levels of cytokines in the lung cancer patients were: (1) in BAL - IL-6, 173 +/- 85 pg/ml; TNF-alpha, 170 +/- 116 pg/ml; and IL-1beta, 473 +/- 440 pg/ml; (2) in the blood - IL-6, 197 +/- 53 pg/ml; TNF-alpha, 311 +/- 202 pg/ml; and IL-1beta, 915 +/- 239 pg/ml. Alveolar macrophages of the patients with a lung cancer secreted significantly more cytokines, IL-6 (P = 0.0004) and IL-1beta (P = 0.0047), than alveolar macrophages of the patients with a nonmalignant lung cancer. However, significantly lower levels of cytokine production by the BAL cells were found in patients with small cell lung cancer. This production decreased further in phase IV of nonsmall cell lung cancer. 相似文献
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Motonobu Nishimura MD Takashi Nishimura MD Masayuki Ishikawa MD Ayumu Masuoka MD Nobuyuki Okamura MD Keiko Abe MD Takahiro Matsuoka MD Mika Iwazaki MD Kazuhito Imanaka MD Haruhiko Asano MD Shunei Kyo MD 《Journal of artificial organs》2006,9(4):209-213
The presence of a significant organ dysfunction does not immediately exclude patients from consideration for treatment with
a left ventricular assist system (LVAS). However, in treating morbid circulatory shock patients with multiple organ failure,
it is important to know the preoperative and postoperative factor or factors related to the recovery of the damaged organ
function. In this study, we retrospectively analyzed patients receiving a LVAS at our institution and tried to determine the
important factors related to the survival of patients with multisystem failure. Twenty-seven patients who underwent LVAS placement
at Saitama Medical School Hospital between 1993 and 2003 were included in this study. The preoperative risk factors analyzed
were renal dysfunction, respiratory dysfunction, hepatic dysfunction, the existence of active infection, and the combination
of all four factors. As a postoperative factor, the pump flow index (mean LVAS pump flow during the first 2 weeks after LVAS
surgery divided by the body surface area) was analyzed. None of the analyzed preoperative factors could predict survival after
LVAS surgery, but a pump flow index of less than 2.5 l/min/m2 had a significant relationship with death after LVAS surgery. Further analysis revealed that all the patients with a pump
flow index of 3.0 l/min/m2 or more could overcome preoperative organ dysfunction. Congestive heart failure patients with multisystem failure need luxury
pump flow for successful LVAS surgery; this factor could be especially important in device selection and postoperative management. 相似文献
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Akihisa Kawajiri Shigehisa Kitano Akiko Miyagi Maeshima Yoshihiro Inamoto Kinuko Tajima Tomonari Takemura Takashi Tanaka Ayumu Ito Keiji Okinaka Saiko Kurosawa Sung‐Won Kim Hirokazu Taniguchi Chitose Ogawa Koji Izutsu Noboru Yamamoto Takahiro Fukuda 《European journal of haematology》2019,103(6):578-587