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1.
S. Suominen I. Antti-Poika K. Tallroth S. Santavirta P. Voutilainen T. S. Lindholm 《Archives of orthopaedic and trauma surgery》1996,115(5):276-279
A total of 113 patients underwent a cemented total hip replacement (THR) operation involving femoral component fixation either without the use of a distal intramedullary plug (n = 57, group 1) or with the plug (n =56, group 2). We studied the femoral component fixation radiographically at on average 6 years after THR. The cement coating was assessed as technically good in 86% and 95% of groups 1 and 2, respectively. There was radiographically diagnosable loosening of the femoral component at the follow-up in 25 cases in which stems were inserted without the intramedullary plug, and in 6 cases in those with the plug (P < 0.0008), and the mean subsidence of the femoral component was 5 mm in group 1 and 1.5 mm (P < 0.0003) in group 2, respectively. Osteolytic changes around the femoral component were noticed in both groups in equal numbers and with no statistical difference. The use of a distal intramedullary plug in the cementation of the femoral stem results in a better cement coating, reduces femoral component subsidence and ameliorates the loosening rates. 相似文献
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Gennadi Naumov Elena Naumova Hilkka Turakainen Pirkko Suominen Matti Korhola 《Current genetics》1991,20(4):269-276
Summary We used a combination of genetic hybridization analysis and electrokaryotyping with radioactively labelled MEL1 gene probe hybridization to isolate and identify seven polymeric genes for the fermentation of melibiose in strain CBS 5378 of Saccharomyces cerevisiae (syn. norbensis). Four of the MEL genes, i.e. MEL3, MEL4, MEL6 and MEL7, were allelic to those found in S. cerevisiae strain CBS 4411 (syn. S. oleaginosus) whereas three genes, i.e. MEL8, MEL9 and MEL10 occupied new loci. Electrokaryotyping showed that all seven MEL genes in CBS 5378 were located on different chromosomes. The new MEL8, MEL9 and MEL10 genes were found on chromosomes XV, X/XIV and XII, respectively. 相似文献
3.
P-fimbriae vaccines 总被引:3,自引:0,他引:3
M. Bernice Kaack Auli Pere Timo K. Korhonen Stefan B. Svenson James A. Roberts 《Pediatric nephrology (Berlin, Germany)》1989,3(4):386-390
To test for cross-protective capacity of two different P-fimbriae vaccines we vaccinated baboons with fimbriae purified from either Escherichia coli strain ER2 or strain JR1. The vaccinated animals showed elevated antibody titers to P-fimbriae from each of the E. coli strains used, suggesting cross-reactivity as was expected from the results of immunoprecipitation of the fimbriae. Enzyme-linked immunosorbent assay inhibition by heterologous P-fimbriae proved this to be true immunologic cross-reactivity. 相似文献
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Summary The effects of ageing and life-long endurance training on the collagen metabolism of skeletal muscle were evaluated in a longitudinal study. Wistar rats performed treadmill running 5 days a week for 2 years. The activities of collagen biosynthesis enzymes, prolyl-4-hydroxylase and galactosylhydroxylysyl glucosyltransferase, were highest in the muscles of the youngest animals, decreased up to the age of 2 months and from then on remained virtually unchanged. The enzyme activity in young animals was higher in the slow collagenous soleus muscle than in the rectus femoris muscle. The enzyme activity in the soleus muscle was higher for older trained rats than older untrained rats. The relative proportion of type I collagen increased and that of type III collagen decreased with age, suggesting a more marked contribution by type I collagen to the agerelated accumulation of total muscular collagen. The results show that collagen biosynthesis decreases with maturation and that life-long endurance training maintains a higher level of biosynthesis in slow muscles. 相似文献
5.
New recombinants within the MHC (B-complex) of the chicken 总被引:2,自引:0,他引:2
In a search for genetic recombinations within the major histocompatibility complex (MHC) of the chicken, the B-complex, the offspring from matings between heterozygous B15/B21 and B4/B6 animals were analysed by red cell agglutination. Among the progeny, 8,912 informative typings were performed. Four recombinants were found, all separating the B-complex loci B-F and B-G (B-F codes for Class I antigens, B-G codes for an antigen of which there is no known homologue in mammals). B-L (Class II antigen) always followed B-F. Stimulation in graft versus host reactions and in mixed lymphocyte cultures followed B-F/B-L. The mapping distance between the two loci B-F and B-G is in the range of 0.04 centimorgan. The lack of recombinants separating individual B-F loci in this study and in the studies of others might indicate that chicken MHC is less complex than those of mammalian species, but alternative explanations are also possible. So far no serologically defined recombinant separating Class I (B-F) and Class II (B-L) loci has been found. 相似文献
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Levodopa, bromocriptine and selegiline modify cardiovascular responses in Parkinson's disease 总被引:2,自引:0,他引:2
Haapaniemi TH Kallio MA Korpelainen JT Suominen K Tolonen U Sotaniemi KA Myllylä VV 《Journal of neurology》2000,247(11):868-874
Autonomic nervous system (ANS) involvement is frequently found in Parkinson's disease (PD), but its causal relationship to
the disease itself and its medication is unclear. We evaluated the effects of PD medications on cardiovascular ANS functions.
Heart rate (HR) responses to normal and deep breathing, the Valsalva manoeuvre and tilting, and blood pressure (BP) responses
to tilting and isometric work were measured prospectively in 60 untreated PD patients randomised to receive either levodopa
(n=20), bromocriptine (n=20) or selegiline (n=20) as their initial treatment. The results were compared with those of 28 healthy controls. The responses were recorded
at baseline, after 6 months on medication and following a 6-week washout period. At baseline HR responses to normal breathing,
deep breathing and tilting were already lower and the fall in the systolic BP immediately and at 5 min after tilting was more
pronounced in the PD patients than in the controls. Six months' levodopa treatment diminished the systolic BP fall after tilting
when compared to baseline, whereas bromocriptine and selegiline increased the fall in systolic BP after tilting and selegiline
diminished the BP responses to isometric work. The BP responses returned to the baseline values during the washout period.
The drugs induced no change in the HR responses. Thus PD itself causes autonomic dysfunction leading to abnormalities in HR
and BP regulation and the PD medications seem to modify ANS responses further. Bromocriptine and selegiline, in contrast to
levodopa, increase the orthostatic BP fall and supress the BP response to isometric exercise reflecting mainly impairment
of the sympathetic regulation.
Received: 17 February 2000 / Received in revised form: 25 May 2000 / Accepted: 15 June 2000 相似文献
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