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排序方式: 共有1119条查询结果,搜索用时 15 毫秒
1.
The sensitivity of cerebellar Purkinje cells to brief iontophoretic applications of excitatory amino acids has been studied in vivo in rats treated from 15 days to 4 months beforehand with 3-acetylpyridine in order to destroy the inferior olive. Responses of Purkinje cells (PCs) chronically deprived of climbing fibers were thus investigated using extracellular microelectrodes and compared to those of a group of control rats. No changes in the relative efficiencies of L-glutamate, L-aspartate, quisqualate and kainate have been observed. In contrast, the excitations induced by N-methyl-D-aspartate (NMDA) on most PCs in control animals, were no longer present after climbing fiber deprivation. These results show that both NMDA and non-NMDA receptors are present on PCs of adult rodents and that the NMDA responses are strongly depressed when PCs are deafferented of the climbing fibers. 相似文献
2.
Foods have always been considered by man as a means of ensuring his physiological needs, allowing the growth, development and preservation of the body and its tissues (nutritional value of food). To this can be added the feelings of satisfaction and well-being that food gives to its consumer, thus constituting an element that is fundamental for our physiological and mental balance (the sensorial value of food).Nevertheless, recent scientific studies have shown that over and above the ensuring of nutritional needs, eating habits can also adjust certain functions of the human organism and thus play a beneficial or harmful role on one's health (the functional value of food).The whole concept of nutrition has been enriched by the notion that eating is not only a survival reflex (satisfaction derived through eating and the avoidance of harmful effects due to eating deficiencies or excesses): eating aims to improve one's health and well-being and to reduce the risk of developing various pathologies. These new data open interesting new horizons in today's context where health is increasingly expensive and people are increasingly concerned to improve their quality of live. 相似文献
3.
Julie Seguier Véronique Gelsi-Boyer Mikael Ebbo Zeinab Hamidou Aude Charbonnier Emmanuelle Bernit Jean-Marc Durand Jean-Robert Harlé Norbert Vey Nicolas Schleinitz 《Autoimmunity reviews》2019,18(1):36-42
Background
We conducted a monocentric retrospective study of patients with myelodysplastic syndromes (MDS) and autoimmune or inflammatory disorders (AIMs) and a literature review. We analyzed the association with subgroups of the WHO 2016 MDS classification and patient's survival in a case control study. Risk factors associated with survival were analyzed by uni- and multivariate analysis.Results
From all MDS patients 11% presented with AIMs. These were heterogeneous and the most frequent where polyarthritis (25%) and autoimmune cytopenias (17%). No difference for frequency and type of AIMs was observed for the WHO 2016 MDS subgroups (p?=?.3). In the case control study WHO classification, karyotype abnormalities, IPSS-R and IPSS were similar in both groups. The overall survival from MDS diagnosis was better in the group with AIMs [10.3?±?0.6 (IC95% 6.2–12.9) versus 4.8?±?1.1?years (IC95% 4.2–8.7), p?=?.04]. The better survival was restricted to MDS with low or intermediate-1 IPSS [11.1?±?1.5 (IC95% 9.9-NR) versus 8.7?±?1.3?years (IC95% 4.8–10.3), p?=?.006]. The better survival was only observed when AIMs diagnosis was timely associated or appeared after MDS diagnosis (p?=?.04). Factors associated with a better overall survival and survival without AML were steroid dependence [respectively HR?=?0.042, p?=?.003, (IC95% 0.005–0.33) and HR?=?0.07, p?=?.002, (IC95% 0.013–0.39)], a diagnosis of AIMs and MDS timely associated [respectively HR?=?0.05, p?=?.009, (IC95% 0.006–0.478) and HR?=?0.1, p?=?.008, (IC95% 0.018–0.54)] or a diagnosis of AIMs after MDS [respectively HR?=?0.024, p?=?.009, (IC95% 0.001–0.39) and HR?=?0.04, p?=?.008, (IC95% 0.003–0.43)].Conclusion
Autoimmune and inflammatory diseases associated to MDS are heterogeneous. AIMs diagnosed after or concomitantly to MDS seems associated with a better survival. Prospective studies are necessary to demonstrate that autoimmunity is associated to a better control of the MDS clone. 相似文献4.
Lozahic S Christiansen D Manié S Gerlier D Billard M Boucheix C Rubinstein E 《European journal of immunology》2000,30(3):900-907
The tetraspans associate with a large number of surface molecules, including a subset of beta1 integrins and, indirectly through CD19, with the complement receptor CD21. To further characterize the tetraspan complexes we have raised and selected monoclonal antibodies (mAb) for their ability to immunoprecipitate a molecule associated with CD9. A unique mAb was identified which recognizes the complement regulator CD46 (membrane cofactor protein). CD46 associated in part with several tetranspans and with all beta1 integrins that were tested (CD29/CD49a, CD29/CD49b, CD29/CD49c, CD29/CD49e, CD29/CD49f) but not with beta4 integrins. These data, together with cross-linking experiments showing the existence in living cells of CD46/integrin complexes, suggest that CD46 associates directly with beta1 integrins and indirectly with tetraspans. CD46 also acts as a receptor for measles virus; however, mAb to various integrins and tetraspans did not modify the virus fusion entry step. 相似文献
5.
Onghena Louis Berrevoet Frederik Vanlander Aude Van Vlierberghe Hans Verhelst Xavier Hoste Eric Poppe Carine 《Quality of life research》2022,31(8):2493-2504
Quality of Life Research - Illness cognitions regarding helplessness and acceptance are known to play a role in health-related quality of life (HRQoL). Our study examined the evolution of these... 相似文献
6.
7.
Bourgain JL Baguenard P Puizillout JM Ankri JC Damia E Billard V 《Annales fran?aises d'anesthèsie et de rèanimation》1999,18(3):303-308
OBJECTIVE: To assess the incidence and the causes of failures of anaesthesia machines. STUDY DESIGN: Prospective survey from August 1995 to September 1997. MATERIAL: Check-list and machine failure forms. METHODS: Failures of anaesthetic machines have been collected and entered into a database. Causes and treatment of each failure have been analysed. RESULTS: Of 5,096 foreseen forms, 3,926 (77%) have been completed after check-list or anaesthesia machine failure. Overall, 233 incidents have been declared (4.5%). Failures identified during the preoperative check-list (n = 96) were mainly related to mechanical problems, especially the gas proportioning device (35%). Perioperative failures (n = 137) were mostly related to electronic problems (ventilator: 27% and monitor: 57%). In more than half of the cases, a specially trained anaesthetic nurse was able to correct the failure in the operating theatre. Using 14 anaesthetic machines for 12 operating rooms, no procedure was cancelled because of a technical failure of a machine. CONCLUSIONS: This study emphasizes the value of the check-list and the failure report. The presence of a specially trained anaesthetic nurse allows immediate correction of the majority of technical problems. 相似文献
8.
A placebo-controlled trial of lamotrigine add-on therapy for partial seizures in children. Lamictal Pediatric Partial Seizure Study Group 总被引:6,自引:0,他引:6
Duchowny M Pellock JM Graf WD Billard C Gilman J Casale E Womble G Risner M Manasco P 《Neurology》1999,53(8):1724-1731
OBJECTIVE: To compare the safety and efficacy of add-on lamotrigine and placebo in the treatment of children and adolescents with partial seizures. BACKGROUND: Add-on and monotherapy lamotrigine is safe and effective in adults with partial seizures, and reports of preliminary uncontrolled trials suggest similar benefits in children. METHODS: We studied 201 children with diagnoses of partial seizures of any subtype currently receiving stable conventional regimens of antiepileptic therapy at 40 study sites in the United States and France. After a baseline observation period (to confirm that more than four seizures occurred in each of two consecutive 4-week periods), patients were randomized to add-on lamotrigine or placebo therapy. A 6-week dose-escalation period was followed by a 12-week maintenance period. RESULTS: Compared with placebo, lamotrigine significantly reduced the frequency of all partial seizures and the frequency of secondarily generalized partial seizures in these treatment-resistant patients. The most commonly reported adverse events in the lamotrigine-treated patients were vomiting, somnolence, and infection; the frequency of these and other adverse events was similar to that in the placebo-treated group, with the exception of ataxia, dizziness, tremor, and nausea, which were more frequent in the lamotrigine-treated group. The frequency of withdrawals for adverse events was similar between groups. Two patients were hospitalized for skin rash, which resolved after discontinuation of lamotrigine therapy. CONCLUSIONS: Lamotrigine was effective for the adjunctive treatment of partial seizures in children and demonstrated an acceptable safety profile. 相似文献
9.
Mavoungou P Billard V Moussaud R Potiron L 《Annales fran?aises d'anesthèsie et de rèanimation》2000,19(8):582-587
OBJECTIVE: Assessment of the usefulness of Bispectral Index of the EEG (BIS) for the management of hypertension during laparoscopic surgery. STUDY DESIGN: Preliminary, non-randomized study. PATIENTS: 15 patients undergoing laparoscopic surgery. METHODS: Anaesthesia by TCI of propofol and boluses of fentanyl in order to maintain fentanyl effect site concentration above 2 ng.mL-1 according to Scott kinetics model. Mean arterial pressure (MAP), heart rate (HR) and BIS were recorded. BIS values between 40 and 60 and MAP between 80 to 120% of preinduction values were maintained using a Gurman like decision matrix. RESULTS: MAP rose significantly after insufflation while variations of HR and BIS were not significant. DISCUSSION: During laparoscopy, factors other than pain can be responsible for hypertension. Nevertheless in clinical practice, inadequate anaesthesia should be ruled out before considering other mechanisms for hypertension. In this study, hypnosis remained adequate with a BIS under 60, and analgesia was considered sufficient as demonstrated by a good stability of the BIS despite nociceptive stimuli. This suggests that more specific haemodynamic factors were responsible for the observed rise in arterial pressure. CONCLUSION: Associating BIS monitoring and MAP in a modified Gurman decision matrix may allow more judicious therapeutic choices for hypertension during laparoscopic surgery. 相似文献
10.
Ewa Żesławska Barbara Oleksyn Aude Fabre Françoise Benoit‐Vical 《Chemical biology & drug design》2014,84(6):669-675
In the search for new antimalarial drugs, design of hybrid molecules is recommended to improve biological activity and to decrease the risk of parasite resistance development. Ellagic acid, as an inhibitor of Plasmodium glutathione, presents an original mode of action and thus appears as a promising antiplasmodial compound. A new complex (AQ–EA) consisting of the well‐known antimalarial drug, amodiaquine, and ellagic acid was obtained. The studied crystal structure of AQ–EA showed that the triclinic centrosymmetrical unit cell of the crystal contains two molecules of amodiaquine (AQ) and two symmetrically independent molecules of ellagic acid (EA). The packing of the molecules in the crystal is dominated by hydrogen bonds between AQ and EA. The antiplasmodial activity of the hybrid complex AQ–EA was also determined and compared with the values of IC50 for AQ and EA separately. Potentiation assays between both molecules were conducted to understand the pharmacological interactions between AQ and EA against Plasmodium falciparum in vitro. The hybrid complex AQ–EA (IC50 of 47 nm ) showed improved antiplasmodial activity in comparison with EA alone. 相似文献