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排序方式: 共有321条查询结果,搜索用时 203 毫秒
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Vladimir Ivancev Ivan Palada Zoran Valic Ante Obad Darija Bakovic Niki M. Dietz Michael J. Joyner Zeljko Dujic 《The Journal of physiology》2007,582(2):723-730
Hypercapnic cerebrovascular reactivity is decreased in obstructive sleep apnoea and congestive heart disease perhaps as a result of repeated apnoeas. To test the hypothesis that repeated apnoeas blunt cerebrovascular reactivity to hypercapnia, we studied breath hold divers and determined cerebrovascular reactivity by measuring changes in middle cerebral artery velocity (MCAV, cm s−1 ) per mmHg change in end-tidal partial pressure of CO2 ( ) in response to two hyperoxic hypercapnia rebreathing manoeuvres (modified Read protocol) in elite breath-hold divers (BHD, n = 7) and non-divers (ND, n = 7). In addition, ventilation and central (beat-to-beat stroke volume measurement with Modelflow technique) haemodynamics were determined. Ventilatory responses to hypercapnia were blunted in BHD versus ND largely due to lower breathing frequency. Cerebrovascular reactivity did not differ between groups (3.7 ± 1.4 versus 3.4 ± 1.3% mmHg−1 in BHD and ND, respectively; P = 0.90) and the same was found for cerebral vascular resistance and MCAV recovery to baseline after termination of the CO2 challenge. Cardiovascular parameters were not changed significantly during rebreathing in either group, except for a small increase in mean arterial pressure for both groups. Our findings indicate that the regulation of the cerebral circulation in response to hypercapnia is intact in elite breath-hold divers, potentially as a protective mechanism against the chronic intermittent cerebral hypoxia and/or hypercapnia that occurs during breath-hold diving. These data also suggest that factors other than repeated apnoeas contribute to the blunting of cerebrovascular reactivity in conditions like sleep apnoea. 相似文献
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Right Ventricular Outflow Tract (RVOT) Changes in Children with an Atrial Septal Defect: Focus on RVOT Velocity Time Integral,RVOT Diameter,and RVOT Systolic Excursion 下载免费PDF全文
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Ante Prki? Christiaan JA van Bergen Bertram The Denise Eygendaal 《World journal of orthopedics》2016,7(1):44-49
The elbow joint is a complex joint, which, when impaired in function, leads to severe disability. In some cases however, an arthroplasty might be an appropriate treatment. In the past four decades, large steps havebeen taken to optimize this treatment in order to achieve better post-operative outcomes. To understand these progresses and to discover aspects for upcoming improvements, we present a review on the past developments, the present state of affairs and future developments which may improve patient care further. 相似文献
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Yap Sing-Chien Anic Ante Breskovic Toni Haas Annika Bhagwandien Rohit E. Jurisic Zrinka Szili-Torok Tamas Luik Armin 《Journal of interventional cardiac electrophysiology》2022,64(3):565-565
Journal of Interventional Cardiac Electrophysiology - 相似文献
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Colombo PC Ganda A Lin J Onat D Harxhi A Iyasere JE Uriel N Cotter G 《Heart failure reviews》2012,17(2):177-190
Although inflammation is a physiologic response designed to protect us from infection, when unchecked and ongoing it may cause
substantial harm. Both chronic heart failure (CHF) and chronic kidney disease (CKD) are known to cause elaboration of several
pro-inflammatory mediators that can be detected at high concentrations in the tissues and blood stream. The biologic sources
driving this chronic inflammatory state in CHF and CKD are not fully established. Traditional sources of inflammation include
the heart and the kidneys which produce a wide range of pro-inflammatory cytokines in response to neurohormones and sympathetic
activation. However, growing evidence suggests that non-traditional biomechanical mechanisms such as venous and tissue congestion
due to volume overload are also important as they stimulate endotoxin absorption from the bowel and peripheral synthesis and
release of pro-inflammatory mediators. Both during the chronic phase and, more rapidly, during acute exacerbations of CHF
and CKD, inflammation and congestion appear to amplify each other resulting in a downward spiral of worsening cardiac, vascular,
and renal functions that may negatively impact patients’ outcome. Anti-inflammatory treatment strategies aimed at attenuating
end organ damage and improving clinical prognosis in the cardiorenal syndrome have been disappointing to date. A new therapeutic
paradigm may be needed, which involves different anti-inflammatory strategies for individual etiologies and stages of CHF
and CKD. It may also include specific (short-term) anti-inflammatory treatments that counteract inflammation during the unsettled
phases of clinical decompensation. Finally, it will require greater focus on volume overload as an increasingly significant
source of systemic inflammation in the cardiorenal syndrome. 相似文献