全文获取类型
收费全文 | 95434篇 |
免费 | 45323篇 |
国内免费 | 161篇 |
专业分类
耳鼻咽喉 | 1764篇 |
儿科学 | 4911篇 |
妇产科学 | 1211篇 |
基础医学 | 17602篇 |
口腔科学 | 5707篇 |
临床医学 | 14103篇 |
内科学 | 27622篇 |
皮肤病学 | 7886篇 |
神经病学 | 14146篇 |
特种医学 | 2908篇 |
外国民族医学 | 9篇 |
外科学 | 17724篇 |
综合类 | 724篇 |
现状与发展 | 1篇 |
一般理论 | 43篇 |
预防医学 | 5675篇 |
眼科学 | 1901篇 |
药学 | 7476篇 |
中国医学 | 1152篇 |
肿瘤学 | 8353篇 |
出版年
2023年 | 362篇 |
2022年 | 1034篇 |
2021年 | 2633篇 |
2020年 | 5715篇 |
2019年 | 11614篇 |
2018年 | 11214篇 |
2017年 | 12081篇 |
2016年 | 12746篇 |
2015年 | 12677篇 |
2014年 | 12785篇 |
2013年 | 13443篇 |
2012年 | 5705篇 |
2011年 | 5698篇 |
2010年 | 9741篇 |
2009年 | 5947篇 |
2008年 | 3041篇 |
2007年 | 1977篇 |
2006年 | 1871篇 |
2005年 | 1498篇 |
2004年 | 1458篇 |
2003年 | 1351篇 |
2002年 | 1383篇 |
2001年 | 1079篇 |
2000年 | 983篇 |
1999年 | 526篇 |
1998年 | 176篇 |
1997年 | 128篇 |
1996年 | 115篇 |
1995年 | 117篇 |
1994年 | 81篇 |
1993年 | 62篇 |
1992年 | 148篇 |
1991年 | 130篇 |
1990年 | 120篇 |
1989年 | 109篇 |
1988年 | 102篇 |
1987年 | 94篇 |
1986年 | 101篇 |
1985年 | 89篇 |
1984年 | 73篇 |
1983年 | 88篇 |
1982年 | 37篇 |
1981年 | 47篇 |
1980年 | 32篇 |
1979年 | 83篇 |
1978年 | 48篇 |
1977年 | 53篇 |
1976年 | 41篇 |
1975年 | 45篇 |
1974年 | 40篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
2.
Mette Nissen Tiina‐Mari Ikheimo Jukka Huttunen Ville Leinonen Henna‐Kaisa Jyrkknen Mikael von und zu Fraunberg 《Neuromodulation》2021,24(1):102-111
ObjectiveSpinal cord stimulation (SCS) is an effective treatment in failed back surgery syndrome (FBSS). We studied the effect of preimplantation opioid use on SCS outcome and the effect of SCS on opioid use during a two-year follow-up period.Materials and methodsThe study cohort included 211 consecutive FBSS patients who underwent an SCS trial from January 1997 to March 2014. Participants were divided into groups, which were as follows: 1) SCS trial only (n = 47), 2) successful SCS (implanted and in use throughout the two-year follow-up period, n = 131), and 3) unsuccessful SCS (implanted but later explanted or revised due to inadequate pain relief, n = 29). Patients who underwent explantation for other reasons (n = 4) were excluded. Opioid purchase data from January 1995 to March 2016 were retrieved from national registries.ResultsHigher preimplantation opioid doses associated with unsuccessful SCS (ROC: AUC = 0.66, p = 0.009), with 35 morphine milligram equivalents (MME)/day as the optimal cutoff value. All opioids were discontinued in 23% of patients with successful SCS, but in none of the patients with unsuccessful SCS (p = 0.004). Strong opioids were discontinued in 39% of patients with successful SCS, but in none of the patients with unsuccessful SCS (p = 0.04). Mean opioid dose escalated from 18 ± 4 MME/day to 36 ± 6 MME/day with successful SCS and from 22 ± 8 MME/day to 82 ± 21 MME/day with unsuccessful SCS (p < 0.001).ConclusionsHigher preimplantation opioid doses were associated with SCS failure, suggesting the need for opioid tapering before implantation. With continuous SCS therapy and no explantation or revision due to inadequate pain relief, 39% of FBSS patients discontinued strong opioids, and 23% discontinued all opioids. This indicates that SCS should be considered before detrimental dose escalation. 相似文献
3.
4.
Abd-Allah H. El Ashmawy Kathleen Dowson Ahmed El-Bakoury Hazem A.H. Hosny Rathan Yarlagadda Jonathan Keenan 《The Journal of arthroplasty》2021,36(3):816-822.e1
BackgroundTotal hip and knee arthroplasties are increasingly performed operations, and routine follow-up places huge demands on orthopedic services. This study investigates the effectiveness, patients’ satisfaction, and cost reduction of Virtual Joint Replacement Clinic (VJRC) follow-up of total hip arthroplasty and total knee arthroplasty patients in a university hospital. VJRC is especially valuable when in-person appointments are not advised or feasible such as during the COVID-19 pandemic.MethodsA total of 1749 patients who were invited for VJRC follow-up for knee or hip arthroplasty from January 2017 to December 2018 were included in this retrospective study. Patients were referred to VJRC after their 6-week postoperative review. Routine VJRC postoperative review was undertaken at 1 and 7 years and then 3-yearly thereafter. We evaluated the VJRC patient response rate, acceptability, and outcome. Patient satisfaction was measured in a subgroup of patients using a satisfaction survey. VJRC costs were calculated compared to face-to-face follow-up.ResultsThe VJRC had a 92.05% overall response rate. Only 7.22% required further in-person appointments with only 3% being reviewed by an orthopedic consultant. VJRC resulted in an estimated saving of £42,644 per year at our institution. The patients’ satisfaction survey showed that 89.29% of the patients were either satisfied or very satisfied with VJRC follow-up.ConclusionVJRC follow-up for hip and knee arthroplasty patients is an effective alternative to in-person clinic assessment which is accepted by patients, has high patient satisfaction, and can reduce the cost to both health services and patients. 相似文献
5.
Major depressive disorder and other neuropsychiatric disorders are often managed with long-term use of antidepressant medication. Fluoxetine, an SSRI antidepressant, is widely used as a first-line treatment for neuropsychiatric disorders. However, fluoxetine has also been shown to increase the risk of metabolic diseases such as non-alcoholic fatty liver disease. Fluoxetine has been shown to increase hepatic lipid accumulation in vivo and in vitro. In addition, fluoxetine has been shown to alter the production of prostaglandins which have also been implicated in the development of non-alcoholic fatty liver disease. The goal of this study was to assess the effect of fluoxetine exposure on the prostaglandin biosynthetic pathway and lipid accumulation in a hepatic cell line (H4-II-E-C3 cells). Fluoxetine treatment increased mRNA expression of prostaglandin biosynthetic enzymes (Ptgs1, Ptgs2, and Ptgds), PPAR gamma (Pparg), and PPAR gamma downstream targets involved in fatty acid uptake (Cd36, Fatp2, and Fatp5) as well as production of 15-deoxy-Δ12,14PGJ2 a PPAR gamma ligand. The effects of fluoxetine to induce lipid accumulation were attenuated with a PTGS1 specific inhibitor (SC-560), whereas inhibition of PTGS2 had no effect. Moreover, SC-560 attenuated 15-deoxy-Δ12,14PGJ2 production and expression of PPAR gamma downstream target genes. Taken together these results suggest that fluoxetine-induced lipid abnormalities appear to be mediated via PTGS1 and its downstream product 15d-PGJ2 and suggest a novel therapeutic target to prevent some of the adverse effects of fluoxetine treatment. 相似文献
6.
7.
8.
Evelyne Harkemanne Jean‐Louis Dargent Pierre‐Paul Roquet‐Gravy Audrey Bulinckx 《Pediatric dermatology》2019,36(3):365-367
We report a case of benign lymphoplasmacytic plaque (LPP) in a child. These asymptomatic erythematous papulonodular lesions are an emerging clinicopathological entity. Herein, we describe a previously unreported site for LPP lesions, namely, the volar wrist and the distal ipsilateral palm. 相似文献
9.
10.
Hawwam Soha Abdalla Ismail Mayada El-Attar Yasmina Ahmed 《Lasers in medical science》2022,37(4):2193-2201
Lasers in Medical Science - Melasma is a chronic, dark brown–pigmented patches and macules commonly on the face. Many treatment modalities for melasma have been used as hydroquinone, laser... 相似文献