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排序方式: 共有453条查询结果,搜索用时 3 毫秒
1.
F Sebastiano G Di Gennaro V Esposito A Picardi R Morace A Sparano A Mascia C Colonnese G Cantore P P Quarato 《Clinical neurophysiology》2006,117(2):341-347
OBJECTIVES: To evaluate a novel method for localization of subdural electrodes in presurgical assessment of patients with drug-resistant focal epilepsy. METHODS: We studied eight consecutive patients with posterior epilepsy in whom subdural electrodes were implanted for presurgical evaluation. Electrodes were detected on post-implantation brain CT scans through a semiautomated procedure based on a MATLAB routine. Then, post-implantation CT scans were fused with pre-implantation MRI to localize the electrodes in relation to the underlying cortical structures. The reliability of this procedure was tested by comparing 3D-rendered MR images of the electrodes with electrode position as determined by intraoperative digital photography. RESULTS: In each patient, all electrodes could be correctly localized and visualized in a stereotactic space, thus allowing optimal surgery planning. The agreement between the procedure-generated images and the digital photographs was good according to two independent raters. The mean mismatch between the 3D images and the photographs was 2 mm. CONCLUSIONS: While our findings need confirmation on larger samples including patients with anterior epilepsy, this procedure allowed to localize subdural electrodes and to establish the spatial relationship of each electrode to the underlying brain structure, either normal or damaged, on brain convessity, basal and medial cortex. SIGNIFICANCE: Being simple, rapid, unexpensive, and reliable, this procedure holds promise to be useful to optimize epilepsy surgery planning. 相似文献
2.
Transcranial cytokine gradients in patients requiring intensive care after acute brain injury 总被引:13,自引:0,他引:13
McKeating E. G.; Andrews PJD.; Signorini D. F.; Mascia L. 《British journal of anaesthesia》1997,78(5):520-523
After acute brain injury there may be increased intracranial production of
cytokines, with activation of inflammatory cascades. We have sought to
determine if a transcranial cytokine gradient was demonstrable in paired
sera of 32 patients requiring intensive care after acute brain injury. The
difference between concentrations of IL-1 beta, IL-6, IL-8 and TNF alpha in
jugular venous and arterial serum was measured on admission, and at 24, 48
and 96 h after the primary injury. There were no differences in IL-1 beta,
IL-8 or TNF alpha, but median gradients of 6.7 and 11.5 pg ml-1 for IL-6
were demonstrated in the traumatic brain injury (n = 22) and subarachnoid
haemorrhage (n = 10) groups, respectively (normal values in serum < 4.7
pg ml-1; P < 0.001 both groups). This suggests that there is significant
production of IL-6 by intracranial cells after acute brain injury. Therapy
directed towards combatting the negative effects of IL-6 may potentially
benefit patients who have sustained an acute brain injury.
相似文献
3.
4.
Michele Guida Addolorata Casamassima Giulia Monticelli Michele Quaranta Giuseppe Colucci 《Journal of translational medicine》2007,5(1):51
Background and purpose
Metastatic renal cell carcinoma (MRCC) has a poor prognosis with a median overall survival of about one year. Since only a minority of patients experienced therapeutic benefit to current treatments, several studies have attempted to identify factors that may have an impact on response and survival. Cytokines play a crucial role in the host's immune response by regulating the development and function of a lot of biological compartments. Nevertheless, available data on basal cytokine levels in MRCC are very few and no clear profile of serum cytokines has been identified yet in these patients population. Thus, determining the levels of cytokines in MRCC could not only help in understanding the biological mechanisms of the tumor growth, but also in evaluating if different cytokine profiles are correlated with particular clinical behaviors. 相似文献5.
Kimberly Mascia Larry Borish James Patrie John Hunt C Douglas Phillips John W Steinke 《Annals of allergy, asthma & immunology》2005,94(6):652-657
BACKGROUND: Aspirin-exacerbated respiratory disease (AERD) is a disease of intense eosinophilic inflammation that can produce fibrosis, hyperplasia, and remodeling. OBJECTIVE: To investigate the usefulness of quantifying severity of chronic hyperplastic eosinophilic sinusitis in predicting the presence of AERD. METHODS: Data were compared between asthmatic patients who reported exacerbations after aspirin ingestion and those who did not. The primary outcome measure was severity of sinusitis using a validated computed tomography (CT) scan-based scoring system. Indices of lower airway remodeling and other markers of inflammation were also evaluated. RESULTS: Twenty-one patients with AERD were compared with 19 patients with aspirin-tolerant asthma (ATA). Patients were well matched for asthma severity as shown by their similar lung function as measured by postbronchodilator forced expiratory volume in 1 second. Patients with AERD were distinguished by their sinus CT scores (AERD patients: 16.9; 95% confidence interval [CI], 13.4-21.3; ATA patients: 6.2; 95% CI, 4.2-9.1; P < .001), and they were considerably more likely to have nasal polyps (AERD patients: 90%; ATA patients: 26%; P < .001). In addition, AERD patients demonstrated increased total lung capacity (AERD patients: 107.9%; 95% CI, 99.9%-117.6%; ATA patients: 98.0%; 95% CI, 93.7%-102.5%; P = .05), reflecting a trend toward increased air trapping. No significant differences occurred in diffusing capacity, exhaled nitric oxide, eosinophilia, or exhaled breath condensate pH. CONCLUSIONS: AERD can be distinguished from ATA by the extent of hyperplasia on CT scan and the presence of nasal polyps. We hypothesize that AERD represents a remodeling process that affects both the upper and lower airways. 相似文献
6.
The effect of hyperbaric oxygen on medial collateral ligament healing in a rat model 总被引:1,自引:0,他引:1
Horn PC Webster DA Amin HM Mascia MF Werner FW Fortino MD 《Clinical orthopaedics and related research》1999,(360):238-242
Hyperbaric oxygen has been shown to promote healing in bone and some soft tissues. This study was undertaken to determine its effect on ligamentous healing. Forty-eight Sprague-Dawley rats underwent a standardized surgical laceration of the right (divided) medial collateral ligament, whereas the left (undivided) medial collateral ligament was not surgically lacerated. A control group of 24 rats recovered without intervention. An experimental group consisting of the other 24 rats was exposed to hyperbaric oxygen at 2.8 atmospheres for 1.5 hours a day for 5 days after the surgery. Six rats from each group were euthanized at 2, 4, 6, and 8 weeks. The stiffness and final force to failure were recorded for the divided and undivided medial collateral ligaments. At 4 weeks, a statistically greater force was required to cause failure of the previously divided ligaments that had been exposed to hyperbaric oxygen than those that had not. The stiffness and force to cause failure of previously divided ligaments were statistically greater at 4 weeks than at 2 weeks, whether or not hyperbaric oxygen was used. No additional statistical increases in stiffness or force were observed at 6 weeks. 相似文献
7.
Ferraresso M Deotto L Conte F Sessa A Mascia G 《International journal of surgical investigation》1999,1(3):185-190
Hemodialysis access achieved through a prosthetic vascular graft has become more popular, especially in diabetic and older patients and those who have had several unsuccessful surgical accesses. From January to December 1996, we implanted a newly available expanded polytetrafluoroethylene (ePTFE) graft (DIASTAT Vascular Access Graft) that allows early cannulation in 18 patients (11 men and 7 women; mean age +/- SD, 63.7 +/- 11 years). Thirteen of these patients had at least one failed vascular access. All grafts were cannulated for dialysis within 7 days of implantation, with flow rates > or = 300 ml/min. The time to hemostasis after the first cannulation ranged from 2 to 4 min. The primary patency rate at one year was 56%. Four grafts developed thrombosis requiring surgical intervention; three were salvaged and one was removed. The one-year assisted or cumulative patency rate was 72%. One patient had persistent bleeding requiring graft revision immediately after surgery. The bleeding stopped and its origin was not determined. There were no graft infections or hematomas. Because of the early cannulation possible with the DIASTAT graft, as well as the lesser time to hemostasis than that generally achieved with standard ePTFE grafts, this prosthesis is a good alternative to autogenous access construction. 相似文献
8.
Giancarlo Colombo Carla Lobina Paola Maccioni M Francesca Mascia Alessandro Orrù Gian Luigi Gessa Mauro A M Carai 《Alcohol》2005,35(1):35-41
In the current study, we investigated the effect of the concurrent presentation of saccharin on the maintenance of alcohol-drinking behavior in selectively bred Sardinian alcohol-preferring (sP) rats. Rats were initially given access to alcohol [10% (volume/volume) in water] and water under the home cage, two-bottle, free-choice regimen, with unlimited access for 24 h/day for eight consecutive weeks. Next, a third bottle, containing saccharin [0%, 0.01%, 0.1%, 1%, or 3% (weight/volume) in water], was concomitantly offered for an additional 10 consecutive days. Intake of saccharin solution resulted as an inverted-U function of saccharin concentration, with the 0.1% saccharin solution being the highest accepted. Alcohol intake was a U function of saccharin concentration, being reduced by 65%-95% in the group of rats exposed to the 0.1% saccharin solution. These results indicate that (1) the concurrent presentation of highly palatable solutions of saccharin markedly reduced alcohol intake in alcohol-experienced sP rats and (2) the reducing effect of saccharin solutions on the alcohol intake in sP rats was positively related to their degree of acceptability. We hypothesized that saccharin solutions may have functioned as a reinforcer, partially substituting for alcohol reinforcement and rendering alcohol drinking less urgent. 相似文献
9.
Donatella Lippi Giuseppe Mascia Luigi Padeletti 《Journal of interventional cardiac electrophysiology》2011,31(3):263-266
The aim of this paper is to underline the role of Sir James Mackenzie in stating that atrial fibrillation is a distinct and
clinically important arrhythmia and that it is a common condition in patients with cardiac disease. Around 1900, a few clinical
researchers were dealing with cardiac arrhythmias with the use of arterial and venous pulse tracings. Sir James Mackenzie,
who has been one of the fathers of modern cardiology, introduced registration of the venous pulse at the bedside using the
clinical polygraph he had invented. He applied the results of his experimental and clinical discoveries to the explanation
of many kinds of arrhythmias before ECG introduction. In our paper, we have especially considered the three steps of his approach
to atrial fibrillation, the first two developed in the pre-ECG era. The invention of an instrument of precision, the electrocardiograph,
revolutionized the diagnosis of heart disease and catalyzed the formation of cardiology as a specialty. 相似文献
10.