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1.
Renal Denervation for Treatment of Cardiac Arrhythmias: State of the Art and Future Directions 下载免费PDF全文
JEDRZEJ KOSIUK M.D. SEBASTIAN HILBERT M.D. EVGENY POKUSHALOV M.D. GERHARD HINDRICKS M.D. Ph.D. JONATHAN S. STEINBERG M.D. ANDREAS BOLLMANN M.D. Ph.D. 《Journal of cardiovascular electrophysiology》2015,26(2):233-238
Renal Denervation for Treatment of Cardiac Arrhythmias . It has now been more than a quarter of a century since modulation of the sympathetic nervous system was proposed for the treatment of cardiac arrhythmias of different origins. But it has also been some time since some of the early surgical attempts have been abandoned. With the development of ablation techniques, however, new approaches and targets have been recently introduced that have revolutionized our way of thinking about sympathetic modulation. Renal nerve ablation technology is now being successfully used for the treatment of resistant hypertension, but the indication spectrum might broaden and new therapeutic options might arise in the near future. This review focuses on the possible impact of renal sympathetic system modulation on cardiac arrhythmias, the current evidence supporting this approach, and the ongoing trials of this method in electrophysiological laboratories. We will discuss the potential roles that sympathetic modulation may play in the future. 相似文献
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Abstract: Different mechanical circulatory support systems (MCSS) have been in clinical use since 1987 to keep patients alive by assisting the heart during cardiac recovery after open heart surgery, myocardial infarction, acute graft failure after heart transplantation, or as a bridge to transplantation in heart transplant candidates. Four different hospitals in Germany used the Berlin Heart Assist Device. Up until 1993, there were 22 patients in the "recovery" group; 4 patients were weaned from the system, and only 1 patient was discharged from the hospital. In 112 patients the Berlin Heart Assist Device was implanted for the purpose of a bridge to transplantation, 68 were transplanted and 46 patients left the hospital. It was concluded that patients may be kept alive with this system for weeks and months after any kind of cardiogenic shock. Complete cardiac recovery may be achieved in patients with early posttransplant graft failure. Reliable prediction of outcome in bridge–to–transplantation patients requires further experience and improvement of system components. 相似文献
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ANDREAS METZNER M.D. PETER RAUSCH M.D. CHRISTINE LEMES M.D. BRUNO REISSMANN M.D. ALEXANDER BARDYSZEWSKI M.D. ROLAND TILZ M.D. ANDREAS RILLIG M.D. SHIBU MATHEW M.D. SEBASTIAN DEISS M.D. MASASHI KAMIOKA M.D. TOBIAS TOENNIS M.D. TINA LIN M.D. FEIFAN OUYANG M.D. KARL‐HEINZ KUCK M.D. ERIK WISSNER M.D. 《Journal of cardiovascular electrophysiology》2014,25(5):466-470
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JEDRZEJ KOSIUK M.D. YVES VAN BELLE M.D. KERSTIN BODE M.D. JELENA KORNEJ M.D. ARASH ARYA M.D. SASCHA ROLF M.D. DANIELA HUSSER M.D. GERHARD HINDRICKS M.D. ANDREAS BOLLMANN M.D. Ph.D. 《Journal of cardiovascular electrophysiology》2012,23(10):1073-1077
Left Ventricular Diastolic Dysfunction in Atrial Fibrillation Background: Left ventricular diastolic dysfunction (LVDD) is common in the general population, but its prevalence in atrial fibrillation (AF), predictors for LVDD in AF and the association between LVDD and AF‐related symptom severity has not been well studied. Methods: In 124 consecutive patients (mean age 61 ± 11years, 60% male) with paroxysmal (n = 70) or persistent AF (n = 54) referred for AF catheter ablation, LVDD was evaluated according to current guidelines using transthoracic echocardiography. AF‐related symptom severity was quantified using the European Heart Rhythm Association score. Results: LVDD was present in 46 patients (37%). In uni‐ and multivariable regression analysis, age (OR 1.068 per year, 95% CI 1.023–1.115, P = 0.003) and persistent AF (OR 2.427 vs. paroxysmal AF, 95% CI 1.112–5.3, P = 0.026) were associated with LVDD. LVDD was found in 11% with mild AF symptoms (n = 27) as opposed to 44% in patients with moderate–severe AF symptoms (n = 97, P = 0.002). Thus, the OR for moderate–severe AF symptoms was 6.368 (1.797–22.568, P = 0.004) in the presence of LVDD. Conclusions: LVDD (1) occurs frequently in AF, (2) is associated with advancing age and AF progression and (3) is correlated with symptom severity in AF. (J Cardiovasc Electrophysiol, Vol. 23 pp. 1073‐1077, October 2012) 相似文献
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LYDIA L. NAKOPOULOU ANASTASIA ALEXIADOU GEORGE E. THEODOROPOULOS ANDREAS CH. LAZARIS ANASTASIA TZONOU ANDONIS KERAMOPOULOS 《The Journal of pathology》1996,179(1):31-38
The immunohistochemical expression of p53 and c-erbB-2 gene proteins was examined in a series of 130 breast adenocarcinomas. This study intended to investigate whether the frequency of the altered expression of the tumour suppressor gene p53 and the overexpression of the oncogene c-erbB-2 in breast cancer tissue cells correlated with other variables known to affect the biological behaviour of these tumours and the overall survival of the patients (median follow-up time: 6 years). The expression of p53 protein and c-erbB-2 gene product was evaluated immunohistochemically. Expression of p53 protein was detected in 30 (23 per cent) of the neoplasms examined, while 26 (20 per cent) out of the 130 cases demonstrated positive c-erbB-2 immunoreactivity. There was a statistically significant association between p53 protein expression and primary tumour size, lymph node involvement, and oestrogen receptor positivity. The incidence of c-erbB-2 positivity was significantly correlated with high tumour grade, axillary node invasion, large tumour size, and the absence of steroid receptors. p53 immuno-expression was clearly associated with c-erbB-2 protein overexpression. Concomitant p53 and c-erbB-2 positive immunolabelling, which emerged in 14 out of the 130 cases (10·7 per cent), was clearly associated with high grade, large size, positive nodal status, ductal infiltrating (NOS) histological type, and low values of progesterone receptors. Overall survival of patients was not significantly related to the immunoreactivity of either p53 or c-erbB-2 considered separately, whereas there was a clearly significant trend to worse overall prognosis in cancers with double p53/c-erbB-2 positive phenotype. The simultaneous immunodetection of p53/c-erbB-2 appears to have greater negative prognostic relevance than their separate expression. 相似文献
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ANDREAS KILLANDER 《Acta paediatrica (Oslo, Norway : 1992)》1959,47(S117):29-33
Summary
An exchange transfusion was performed in an infant with neonatal thrombocytopenic purpura. Both the infant and the mother presented some unusual features, which are briefly discussed. Although the disease is self-limited, the high mortality during the first days after birth indicates the use of effective therapy as soon as possible. Compared to other methods of treatment, exchange transfusion seem to be the best in several respects. It is suggested that women with idiopathic thrombocytopenic purpura should be delivered in hospitals with exchange transfusion units and laboratories for haemato-logical serology. 相似文献
An exchange transfusion was performed in an infant with neonatal thrombocytopenic purpura. Both the infant and the mother presented some unusual features, which are briefly discussed. Although the disease is self-limited, the high mortality during the first days after birth indicates the use of effective therapy as soon as possible. Compared to other methods of treatment, exchange transfusion seem to be the best in several respects. It is suggested that women with idiopathic thrombocytopenic purpura should be delivered in hospitals with exchange transfusion units and laboratories for haemato-logical serology. 相似文献