马来酸桂哌齐特治疗高血压性脑出血临床疗效及安全性观察

目的 探讨马来酸桂哌齐特对高血压性脑出血的出血、水肿吸收以及神经功能损伤恢复方面的临床疗效,同时观察其不良反应.方法 98例高血压性脑出血患者,随机分为对照组和治疗组,对照组给予高血压性脑出血常规治疗,治疗组加用马来酸桂哌齐特320mg静滴,每日1次,共用14d.分别于治疗前、治疗14d后测定血肿和水肿体积、NIHSS评分、Barthel指数及血压、心率水平、血白细胞计数(WBC)、肝肾功能、血糖及凝血功能,并观察不良反应发生情况.结果 治疗14d后治疗组血肿、水肿体积均较对照组明显缩小,差异具有统计学意义(P<0.05);两组病例NIHSS评分及BI评分治疗前后差异均有统计学意义(P<0.05),治疗14d后治疗组NIHSS评分及BI评分差异具有统计学意义(P<0.05);两组显效率及总有效率差异均具有统计学意义(P<0.05);治疗组治疗前后患者心率、血白细胞计数(WBC)、肝肾功能及凝血功能等各项指标差异均无统计学意义.结论 马来酸桂哌齐特可促进高血压性脑出血水肿和血肿吸收,改善神经功能缺损及病残程度,不良反应出现少,安全性较好.

Abstract：

Objective To evaluate the clinical efficacy and safety profile of cinepazide maleate for the treatment of hypertensive hemorrhage by observing the absorption of blood blots and brain edema, recovery of nervous system functions,and adverse reaction of this drug. Methods 98 patients with hypertensive hemorrhage were divided into two groups randomly:the control group and the therapy group. Patients in the control group were given routine treatment, while patients in therapy group were administrated with cinepazide maleate 320mg ivgtt. Qd, and the course of treatment was 14 days for both groups. Volume of blood blot and edema, NIHSS score, Barthel index (BI), blood pressure, heart rate, WBC, ALT, AST, Cr,BUN, blood glucose and blood clotting function of each patient were all evaluated before and after treatment course;meanwhile, adverse reactions were under tight observations. Results After treatments for 14 days,a significant decrease in volumes of blood blot and edema was noticed in all patients of therapy group compared to those of control group ( P < 0.05 ).Statistical differences of NIHSS score and BI were observed in two groups before and after treatments ( P < 0.05 ), this trend also existed in the comparison between therapy group and control group ( P < 0. 05 ). There were significant differences of effect efficiency in two groups ( P < 0. 05 ), with the same as the total effect efficiency ( P < 0.05 ). No statistical differences of heart rate,WBC,ALT, AST, Cr, BUN, blood glucose and blood clotting function were detected in therapy group before and after treatments. Conclusions Cinepazide maleate may facilitate the absorption of blood blot and edema for patients with hypertensive hemorrhage, improve the impaired function of nervous system, and decrease the disability extent.Moreover,cinepazide maleate is a safe drug with few adverse reactions.     

采用多种措施预防和治疗褥疮

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献上深深的哀思——追忆本刊原副主编、我国著名免疫学家陈慰峰院士

<中国免疫学杂志>原副主编、我国著名免疫学家、博士生导师、中国科学院院陈慰峰院士永远走了,走的这么突然,留给我们只有无尽的哀思和追忆…….     

1993年第9卷主题词索引

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疾病特别是癌症对病人产生的压力以及采取的相应诊治方法都可以影响病人的生活质量。为了提高病人的生活质量，蛤员应从生理、心理、社会、精神状态４个方面，改进和提高护理质量。护理训练及其研究中也应增有关重要内容。