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老年人痴呆30例尸检分析 总被引:4,自引:0,他引:4
对30例老年人痴呆及13例非痴呆老年人的尸检材料进行临床和病理分析。发现老年人痴呆以血管性痴呆最多(13例,占43.3%),其次为阿茨哈默病(6例,占20.0%)、混合型痴呆(6例,占20.0%)及皮质下动脉硬化性脑病(5例,占16.7%)。对不同类型的老年人痴呆的神经病理学特征进行了讨论。 相似文献
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目的 为加强对肝豆状核变性疾病的认识并提高其诊断正确性。方法 对遗传特点、起病首发症状及临床表现、头颅MRI特点进行分析和探讨。结果 所报告的2例患者均无家族遗传病史。第一例首发症状为手颤及精神症状,因精神症状比较突出最初被诊断为“精神性疾病”,经抗精神治疗达1年之久方被确诊;第二例首发症状为进行性智能障碍及神经系统症状.因头颅MRI特殊表现开始曾被诊断为“胶质瘤”、“脑囊虫病”、“多发性硬化”近1年.后通过创伤性脑活检才被确诊为肝豆状核变性疾病。结论 该病之所以被延迟诊断主要因首发症状及临床表现的多样性、头颅MRI改变多样化、无家族遗传病史以及医生缺乏对此病的认识等多种因素所致。 相似文献
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Objective To observe the incidence rate of non-alcoholic fatty liver disease (NAFLD) in elderly male patients with type 2 diabetes mellitus (T2DM) and the features of pathological changes of liver. Methods The 89 cases with T2DM (T2DM group) and contemporary non-diabetic cases (control group, n=48) from 858 autopsy samples matched for gender and age were selected in the study. The histopathological changes of liver were observed by microscopy,histochemistry and immunohistochemistry. Results The incidence rates of NAFLD and nonalcoholic steatohepatitis(NASH) were 49.4% (44/89) and 14.6% (13/89) in T2DM group, 22.9 %(11/48) and 4.2% (2/48) in control group, respectively. The incidence rates of NAFLD and NASH were significantly higher in T2DM group than in control group(P<0.01, P<0.05). All of the NASH patients from T2DM group and one patient from control group were complicated with different stages of liver fibrosis. One patient from T2DM group was diagnosed as cirrhosis, no cirrhosis patient was found in control group. Conclusions Compared with control group, the incidence rate of NAFLD is higher and the damage of liver is more severe in T2DM group. The ratio of the progress from NAFLD to liver cirrhosis is low. 相似文献
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Objective To observe the incidence rate of non-alcoholic fatty liver disease (NAFLD) in elderly male patients with type 2 diabetes mellitus (T2DM) and the features of pathological changes of liver. Methods The 89 cases with T2DM (T2DM group) and contemporary non-diabetic cases (control group, n=48) from 858 autopsy samples matched for gender and age were selected in the study. The histopathological changes of liver were observed by microscopy,histochemistry and immunohistochemistry. Results The incidence rates of NAFLD and nonalcoholic steatohepatitis(NASH) were 49.4% (44/89) and 14.6% (13/89) in T2DM group, 22.9 %(11/48) and 4.2% (2/48) in control group, respectively. The incidence rates of NAFLD and NASH were significantly higher in T2DM group than in control group(P<0.01, P<0.05). All of the NASH patients from T2DM group and one patient from control group were complicated with different stages of liver fibrosis. One patient from T2DM group was diagnosed as cirrhosis, no cirrhosis patient was found in control group. Conclusions Compared with control group, the incidence rate of NAFLD is higher and the damage of liver is more severe in T2DM group. The ratio of the progress from NAFLD to liver cirrhosis is low. 相似文献
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垂体多激素脉瘤的临床病理分析及免疫电镜观察 总被引:1,自引:0,他引:1
应用免疫组化及免疫电镜技术,对30例垂体多激素腺瘤患者进行了观察。结果显示:二种激素阳性者18例,包括生长激素-催乳素腺瘤16例,生长激素-促甲状腺激素腺瘤1例,生长激素-促肾上腺皮质激素腺交瘤1例;三种激素阳性2例,包括生长激素-催乳素-促甲状腺激素腺瘤1例,生长激素-黄体生成素-卵泡刺激素腺瘤2例;四种激素阳性9例,包括生长激素-催乳素-黄体生成素-卵泡刺激素腺瘤1例,生长激素-促甲状腺激素- 相似文献