全文获取类型
收费全文 | 328701篇 |
免费 | 12265篇 |
国内免费 | 6219篇 |
专业分类
耳鼻咽喉 | 2503篇 |
儿科学 | 5514篇 |
妇产科学 | 4424篇 |
基础医学 | 19799篇 |
口腔科学 | 8394篇 |
临床医学 | 34887篇 |
内科学 | 38421篇 |
皮肤病学 | 3469篇 |
神经病学 | 13627篇 |
特种医学 | 17665篇 |
外科学 | 39908篇 |
综合类 | 78148篇 |
一般理论 | 20篇 |
预防医学 | 35589篇 |
眼科学 | 4914篇 |
药学 | 17214篇 |
2篇 | |
中国医学 | 6946篇 |
肿瘤学 | 15741篇 |
出版年
2024年 | 70篇 |
2023年 | 661篇 |
2022年 | 760篇 |
2021年 | 1496篇 |
2020年 | 1454篇 |
2019年 | 1663篇 |
2018年 | 2516篇 |
2017年 | 1885篇 |
2016年 | 2033篇 |
2015年 | 2110篇 |
2014年 | 2217篇 |
2013年 | 2966篇 |
2012年 | 4271篇 |
2011年 | 20474篇 |
2010年 | 10160篇 |
2009年 | 5945篇 |
2008年 | 17335篇 |
2007年 | 30187篇 |
2006年 | 29729篇 |
2005年 | 23580篇 |
2004年 | 24934篇 |
2003年 | 24896篇 |
2002年 | 21793篇 |
2001年 | 19865篇 |
2000年 | 15102篇 |
1999年 | 15709篇 |
1998年 | 8372篇 |
1997年 | 9520篇 |
1996年 | 9308篇 |
1995年 | 8653篇 |
1994年 | 7575篇 |
1993年 | 3970篇 |
1992年 | 3605篇 |
1991年 | 2850篇 |
1990年 | 2388篇 |
1989年 | 1736篇 |
1988年 | 1899篇 |
1987年 | 1063篇 |
1986年 | 799篇 |
1985年 | 516篇 |
1984年 | 164篇 |
1983年 | 86篇 |
1982年 | 79篇 |
1981年 | 68篇 |
1980年 | 66篇 |
1979年 | 67篇 |
1978年 | 50篇 |
1977年 | 65篇 |
1974年 | 44篇 |
1973年 | 49篇 |
排序方式: 共有10000条查询结果,搜索用时 125 毫秒
1.
Esin Benli Küçük Ercan Kaydok Kürsad Ramazan Zor Gamze Yıldırım Biçer 《Topics in stroke rehabilitation》2020,27(8):630-635
ABSTRACT Objective: Dry eye is reported to be associated with several neurological diseases. The aim of this study is to evaluate the patients with hemiplegia after stroke for dry eye and compare their results with a control group. Materials and methods: Forty-five patients with hemiplegia and 45 individuals as the control group were included in the study. Tear function tests (Schirmer and tear breakup time) and a dry eye questionnaire for dry eye symptoms (ocular surface disease index) were performed and the results of the two groups were compared. Results: Schirmer test results were significantly lower in the post-stroke hemiplegia group compared to the control group (11.3 ± 8.2 mm and 20.6 ± 11.6 mm, respectively, p < .001). Tear breakup time results were significantly lower in the post-stroke hemiplegia group compared to the control group (7.9 ± 3.1 s and 12.1 ± 4.3 s, respectively, p < .001). Ocular surface disease index scores were not significantly different between hemiplegia and control groups (21.6 ± 20.0 and 19.8 ± 13.9, respectively, p = .635). Schirmer scores lower than 10 mm (60% and 30%, p < .001) and tear breakup time results lower than 10 s (65.6% and 28.9%, p < .001) were also higher in the hemiplegia group compared to control group. Conclusion: We found lower Schirmer test and tear breakup time results and similar OSDI scores in hemiplegia patients compared to controls. Hemiplegia patients may have dry eye without typical symptoms. This should be taken into consideration in the follow-up and rehabilitation of post-stroke hemiplegia patients. 相似文献
2.
目的:探讨健脾益肾方对非小细胞肺癌(NSCLC)细胞体外增殖凋亡的作用。方法:人NSCLC细胞系A549分为四组:空白对照组(仅加入细胞培养液)、阴性对照组(加入细胞,不进行中药处理)、实验组(加细胞加中药处理)。荧光定量PCR和Western blot分别检测Survivin、Bcl-2和Caspase-3的mRNA和蛋白表达。MTT检测细胞增殖;流式细胞术检测细胞凋亡。结果:与空白对照组相比,阴性对照组细胞在24、48、72 h的吸光度值明显升高,细胞凋亡率下降,Survivin和Bcl-2 mRNA和蛋白相对表达量上调,Caspase-3 mRNA和蛋白相对表达量下调,组间比较差异有统计学意义(P<0.05);而健脾益肾方处理的实验组24、48、72 h的吸光度值均显著降低,细胞凋亡率显著上升,Survivin和Bcl-2 mRNA和蛋白相对表达量下调,Caspase-3 mRNA和蛋白相对表达量上调,与空白对照组相比差异有统计学意义(P<0.05)。结论:健脾益肾方可通过下调Survivin和Bcl-2、上调Caspase-3表达诱导NSCLC细胞凋亡,并抑制肿瘤细胞的增殖,进而抑制NSCLC的发展。 相似文献
3.
4.
5.
6.
7.
Claire Letournel François Babinet Bénédicte Allard Vincent Montecot 《Néphrologie & thérapeutique》2019,15(1):51-58
Objective
The “Centre Hospitalier Francois Dunan” is located on an isolated island and ensures patients care in hemodialysis thanks to telemedicine support. Many research studies have demonstrated the importance of hemodialysis fluids composition to reduce morbidity in patients on chronic hemodialysis. The aim of this study was to identify the risks inherent in the production of dialysis fluids in a particular context, in order to set up an improvement action plan to improve risk control on the production of dialysis fluids.Methods
The risk analysis was conducted with the FMECA methodology (Failure Mode, Effects and Criticality Analysis) by a multi professional work group. Three types of risk have been reviewed: technical risks that may impact the production of hemodialysis fluids, health risks linked with chemical composition and health risks due to microbiological contamination of hemodialysis fluids.Results
The work group, in close cooperation with the expert staff of the dialysis center providing telemedicine assistance, has developed an action plan in order to improve the control of the main risks brought to light by the risk analysis.Conclusion
The exhaustive analysis of the risks and their prioritisation have permitted to establish a relevant action plan in this improving quality of dialysis fluids approach. The risk control of dialysis fluids is necessary for the security of dialysis sessions for patients, even more when these sessions are realized by telemedicine in Saint-Pierre-et-Miquelon. 相似文献8.
9.
10.