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1.
2.
Objective: The scientific quality of research is an important ethical issue. To clarify the quality of research projects in pharmacotherapy/pharmacology,
40 randomly selected research projects in pharmacotherapy/pharmacology submitted to a research ethics committee were reviewed.
Results: Eight of the projects would not have contributed new knowledge nor were they necessary as controls for the results of previous
research. Fifteen of the research protocols were of good quality, 15 could be used after revisions, and 10 were unfit for
use. Eleven of the research projects were not finished 5 years after they were started. A written report was produced from
26 of the projects. Nine were of good quality and could be accepted for publication in a medical journal, 10 of the reports
were in need of revision before publication, and 7 should not be accepted for publication.
Conclusion: Research in this field ought to be improved, and ways to improve the standard of clinical trials in pharmacotherapy are
dicussed.
Received: 1 April 1996 / Accepted in revised form: 28 June 1996 相似文献
3.
4.
Ø. G. Martinsen S. Grimnes E. S. Kongshaug 《Medical & biological engineering & computing》1997,35(3):177-180
Some electrical properties of human hair have been investigated to determine whether a significant DC electrical conductance
is present in keratinised tissues. The DC conductance was found to be substantial and highly dependent on the moisture level
in the hair fibres. At high moisture levels, the conductance was found to be almost frequency independent below 1 kHz. Absorption
and desorption profiles were also monitored, revealing different stages of sorption mechanisms in the fibres. Although absorption
was found to be a slow process with ‘time constants’ in the range of hours, desorption was much faster, in the range of a
few minutes. 相似文献
5.
Summary The prevalence of virus-specific serum antibodies of IgA class against cytomegalovirus (CMV) was determined in 228 healthy blood donors and in 112 patients suspected of CMV infection. All patients had a titer of 40 or higher in the complement fixation test. Specific CMV-IgA was found in 81 per cent of CMV-IgM positive patient sera and in 20 per cent of sera from patients strongly suspected of CMV infection, but with negative CMV-IgM. Less than 2 per cent of healthy blood donors had CMV specific serum IgA.With 4 Figures 相似文献
6.
N. Ø. Christensen R. Nydal F. Frandsen S. B. Sirag P. Nansen 《Parasitology research》1981,65(3):293-298
Schistosoma sp. induced cross-resistance to a challenge withFasciola hepatica andEchinostoma revolutum was studied in mice. Primary patent 56-days-oldS. intercalatum andS. bovis infections stimulated a statistically significant level of resistance to a challenge withF. hepatica, and primary patent 100-day-oldS. bovis infections induced an almost complete resistance to a challenge withE. revolutum. Primary single-sexS. mansoni infections, either male or female, aged 90 days did not stimulate any resistance to a challenge withE. revolutum.A primary infection withS. mansoni aged 70 days induced a marked reduction (94.1–100%) in theE. revolutum worm recovery already 2 h post-challenge as compared with that of theE. revolutum challenge control group and complete elimination of the echinostome worm population inS. mansoni infected mice had taken place 24 h after challenge.
E. revolutum worm populations established in mice harbouring newly patent 36-day-oldS. mansoni infections persisted unchanged for a period of at least 33 days into the patent period of the schistosome infection in spite of development of a complete resistance to a challenge withE. revolutum metacercariae during this period. 相似文献
7.
8.
J. Ø. Odland V. P. Tchachtchine V. Bykov P. E. Fiskebeck E. Lund Y. Thomassen E. Nieboer 《International archives of occupational and environmental health》1999,72(3):151-160
Background: The feasibility study described herein was prompted by a report in 1992 of possible reproductive and developmental health
concerns among female workers in a Russian nickel refinery. Objective: The primary goal was to ascertain whether medical, statistical, and occupational data bases could be accessed for information
about the pregnancy histories, occupational histories, and life-style factors of the women affected. Methods: The project was facilitated by construction of a registry of all births in three towns with a nickel refinery and verification
of its contents against patients' records obtained from hospital delivery and gynecology departments and community polyclinics.
Municipal Registration Board, Regional Health Statistics Board, and nickel company records were also reviewed. Results: Reproductive/developmental outcome information and workplace histories were acceptable. Sample-size calculations indicated
that a cohort or cross-sectional study would be amenable and suitable for the detection of an excess risk for spontaneous
abortion with adequate statistical significance and power. Such investigations would need to be supplemented by workplace
environmental/biological monitoring assessments for evaluation of exposure to occupational hazardous factors and a worker's
questionnaire to obtain information about life-style factors. A case-control design is recommended for the study of congenital
defects. Conclusions: A well-designed, comprehensive epidemiology study is technically feasible because of the availability of a favorable pool
of study subjects, reproductive/developmental outcome data, information to control for major confounders, and suitable occupational
records.
Received: 13 July 1998 / Accepted: 7 February 1999 相似文献
9.
Ø. Stenbæk E. Myhre H. Erik Rugstad Elisabeth Arnold T. Hansen 《European journal of clinical pharmacology》1977,12(2):117-123
Summary The pharmacokinetics of 2-14C-L--methyldopa have been investigated in five healthy volunteers following intravenous and oral administration. In the intravenous study a bi-phasic plasma concentration curve was found both for chemically determined -methyldopa and for radioactivity. The plasma level of radioactivity differed significantly from chemically determined drug, a pattern which was also found in urine. This suggests the presence of unidentified metabolite(s). The difference between plasma disappearance and urine recovery of -methyldopa and radioactivity during the first 4 h after injection suggests distribution to an extravascular compartment. Plasma half-lives of total radioactivity and of unchanged drug were calculated. In three subjects, pharmacokinetic parameters for a two-compartment open body model were calculated from urine and plasma data. Urinary recovery of radioactivity was almost complete within 48 h after intravenous administration. After oral administration, however, only about 40 per cent of the radioactive dose was recovered in the urine, and it contained approximately equal amounts of unconjugated methyldopa, acid-labile conjugated methyldopa and unidentified metabolite(s). The acid-labile conjugate was found only after oral administration, which supports the theory of a mucosal conjugation process. The lack of acid-labile conjugated drug either in the plasma or urine after intravenous injection indicates that there is no enterohepatic circulation of this drug. 相似文献