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排序方式: 共有159条查询结果,搜索用时 15 毫秒
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Velimir Matkovic MD PhD Nancy Badenhop-Stevens RD MSc Eun-Jeong Ha PhD Zeljka Crncevic-Orlic MD PhD Albert Clairmont MD 《Clinical reviews in bone and mineral metabolism》2002,1(3-4):233-248
Bone accretion during childhood is proportional to the rate of growth. During this time, interval height velocity is relatively
slow for both boys and girls. As a direct consequence of this, calcium retention in the body of an average child is lower
than the calcium retention in an adolescent. Bone size, bone mass, and bone mineral areal density of the regional skeletal
sites increase on average by about 4%/yr from childhood to late adolescence and young adulthood, when most of the bone mass
is accumulated. Calcium needs are greater during adolescence (pubertal growth spurt) than in childhood or adulthood. According
to calcium balance studies, the threshold in take for adolescents is about 1500 mg/d. Inadequate calcium intake during growth
may increase the risk of childhood fractures and predispose certain individuals to a lower peak bone mass. 相似文献
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Normal brain function depends critically on cholesterol. Although cholesterol is synthesized locally in the adult brain, the precise anatomical localization of cholesterogenic enzymes is not known. Here we show that 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoAred) and 7-dehydrocholesterol reductase (7dhcred), the first and last enzymes, respectively, in the cholesterol biosynthesis pathway, are co-expressed in neurons throughout adult murine brain. Co-localization is most prominent in cortical, hippocampal, and cholinergic neurons. Since adult hippocampal and cholinergic neurons express p75 neurotrophin receptors (p75NTR) we hypothesized that p75NTR regulates expression of cholesterogenic enzymes. Treatment of Neuro2a neuroblastoma cells or primary cerebellar cultures with siRNA downregulates p75NTR and decreases the expression level of HMG-CoAred and 7dhcred. Native neuroblastoma cell lines with differential expression of p75NTR differentially express 7dhcred; 7dhcred expression correlates with p75NTR expression. This suggests that, in p75NTR-expressing cells, p75NTR regulates cholesterol synthesis through regulation of HMG-CoAred and 7dhcred expression. The unexpected localization of cholesterogenic enzymes in adult neurons suggests that at least some adult neurons retain the ability to synthesize cholesterol. 相似文献
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Mrzljak Anna Dinjar-Kujundzic Petra Knotek Mladen Kudumija Boris Ilic Mario Gulin Marijana Zibar Lada Hrstic Irena Jurekovic Zeljka Kolaric Branko Jemersic Lorena Prpic Jelena Tomljenovic Morana Vilibic-Cavlek Tatjana 《International urology and nephrology》2020,52(2):371-378
International Urology and Nephrology - Data on the seroprevalence of hepatitis E virus (HEV) in heamodialysis (HD) patients are conflicting, ranging from 0 to 44%. The aim of this study was to... 相似文献
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Thomas Nickel Henner Hanssen Zeljka Sisic Susanne Pfeiler Claudia Summo Daniel Schmauss Eva Hoster Michael Weis 《European journal of nutrition》2011,50(3):163-172
Purpose
Atherosclerosis is known to be an inflammatory disease. Dendritic cells (DCs) are essential for the regulation of the immune system. Up to 10% of the cells in atherosclerotic plaques are DCs. The cardiovascular protective effects of flavonoids (tea, wine) may be mediated by anti-inflammatory mechanisms that affect DC regulation. We aimed to characterize the impact of the flavonol quercetin on DC activity and differentiation in vitro and in vivo. 相似文献7.
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Tatomirović Z Bokun R Skuletić V Ilić S Roganović B Milutinović D 《Vojnosanitetski pregled. Military-medical and pharmaceutical review》2004,61(5):561-564
Sister Mary Joseph's nodule is the eponym for metastatic involvement of the umbilicus. This less common entity is the sign of disseminated malignant disease, mainly of digestive and gynecologic origin, and is associated with a poor prognosis. A case of Sister Mary Joseph's nodule in a 76-year-old woman in whom the umbilical metastasis was the first sign of malignant disease in presented. The diagnosis of metastatic adenocarcinoma was established by fine needle aspiration cytology of the umbilical nodule. Radiological and ultrasonographic investigation disclosed carcinoma of the gallbladder with pancreas, stomach, and colon invasion as well as peritoneal dissemination. The diagnosis was confirmed by exploratory laparatomy and histological examination of the excised umbilical nodule. 相似文献
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CD95/Fas expression on peripheral blood T lymphocytes in patients with multiple sclerosis: effect of high-dose methylprednisolone therapy 总被引:1,自引:0,他引:1
Petelin Z Brinar V Petravic D Zurak N Dubravcic K Batinic D 《Clinical neurology and neurosurgery》2004,106(3):259-262
Recent data indicate that the apoptotic process, mediated by the CD95/Fas cell surface receptor, is impaired in activated lymphocytes of patients with relapsing-remitting multiple sclerosis. Using flow cytometric-immunophenotyping, we analyzed the expression of CD95/Fas on peripheral blood CD4+ and CD8+ T lymphocytes (PBL) in 10 MS patients in relapse, and the effect of pulse corticosteroid therapy on the apoptosis of autoreactive lymphocytes. The proportions of CD8+ and CD8+CD95+ T lymphocytes were significantly higher in MS patients in relapse before than after pulse corticosteroid therapy. Conversely, the proportions of CD4+ and CD4+CD95+ T cells were significantly lower before than after therapy, but not significantly different from healthy persons. The different expression of CD95/Fas on peripheral blood CD8+ T lymphocytes in relapsing RRMS and in healthy controls suggests a possible involvement of apoptosis in the pathogenesis of MS. Our results also show that pulse corticosteroid therapy influences the CD95/Fas expression on CD8+ and CD4+ T lymphocytes in patients with RRMS. 相似文献
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