全文获取类型
收费全文 | 655篇 |
免费 | 47篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 17篇 |
妇产科学 | 97篇 |
基础医学 | 61篇 |
口腔科学 | 5篇 |
临床医学 | 66篇 |
内科学 | 91篇 |
皮肤病学 | 4篇 |
神经病学 | 30篇 |
特种医学 | 46篇 |
外科学 | 112篇 |
综合类 | 18篇 |
一般理论 | 1篇 |
预防医学 | 45篇 |
眼科学 | 43篇 |
药学 | 29篇 |
肿瘤学 | 32篇 |
出版年
2022年 | 4篇 |
2020年 | 5篇 |
2018年 | 13篇 |
2017年 | 4篇 |
2016年 | 6篇 |
2015年 | 6篇 |
2014年 | 11篇 |
2013年 | 18篇 |
2012年 | 23篇 |
2011年 | 21篇 |
2010年 | 16篇 |
2009年 | 20篇 |
2008年 | 17篇 |
2007年 | 35篇 |
2006年 | 30篇 |
2005年 | 24篇 |
2004年 | 28篇 |
2003年 | 24篇 |
2002年 | 18篇 |
2001年 | 20篇 |
2000年 | 25篇 |
1999年 | 17篇 |
1998年 | 11篇 |
1997年 | 13篇 |
1996年 | 15篇 |
1995年 | 16篇 |
1994年 | 8篇 |
1993年 | 16篇 |
1992年 | 10篇 |
1991年 | 15篇 |
1990年 | 18篇 |
1989年 | 25篇 |
1988年 | 21篇 |
1987年 | 15篇 |
1986年 | 13篇 |
1985年 | 15篇 |
1984年 | 10篇 |
1983年 | 5篇 |
1982年 | 7篇 |
1981年 | 6篇 |
1980年 | 9篇 |
1979年 | 13篇 |
1978年 | 4篇 |
1977年 | 9篇 |
1975年 | 9篇 |
1974年 | 3篇 |
1973年 | 8篇 |
1971年 | 4篇 |
1968年 | 3篇 |
1967年 | 3篇 |
排序方式: 共有704条查询结果,搜索用时 15 毫秒
1.
2.
L R Baker W J Mallinson M C Gregory E A Menzies W R Cattell H N Whitfield W F Hendry J E Wickham A M Joekes 《British journal of urology》1987,60(6):497-503
Sixty patients with idiopathic retroperitoneal fibrosis presenting between 1965 and 1984 are reviewed. Their mean age at presentation was 56 years and the male:female ratio was 3:1. The commonest presenting symptoms were flank and abdominal pain, weight loss, nausea and polyuria. Physical examination was usually normal, expect for the presence of hypertension. Anaemia and elevation of erythrocyte sedimentation rate were usually present. Proteinuria was found in less than a third of patients at presentation and significant bacteriuria was uncommon. The correct diagnosis was made or suspected in very few patients before referral. The cumulative actuarial survival rate was 86% at 1 year and 78% at 2 years. Seventeen patients died; they were significantly older and more uraemic at the time of referral than those who survived. A few patients did well with either corticosteroid therapy or ureterolysis alone. In the majority, both operation and steroid treatment were necessary. In bilateral obstruction with residual function in both kidneys, bilateral ureterolysis proved superior to unilateral operation (each followed by steroid therapy) in conserving renal function. Operation alone or steroid therapy alone should be considered in cases where steroids or surgery respectively present particular hazards. The less traumatic unilateral operation should be considered in poor risk patients and in those whose renal function is absent on one side. In many survivors, disease activity has persisted for many years. Life-long follow-up is recommended. 相似文献
3.
4.
5.
BACKGROUND & AIMS: Nutrients and properties of lipases affect survival of lipolytic activity during aboral gastrointestinal transit. Whether different doses and formulations of bacterial lipase and diets affect steatorrhea was tested in pancreatic-insufficient dogs. METHODS: A dose of 0-600,000 IU of powdered and 135,000 and 300,000 IU of liquid bacterial lipase was given with a standard meal to 5 dogs with ligated pancreatic ducts. In 4 dogs, 0 or 300,000 IU (normal 6-hour postprandial amount) of powder bacterial lipase was also given with five meals containing 850 kcal with different nutrient caloric densities (mixture design). Coefficients of fat absorption during 72- hour fecal balance studies were used to assess treatments. RESULTS: With the standard meal, powder bacterial lipase reduced steatorrhea in a dose-dependent manner (P = 0.03), and 135,000 and 300,000 IU of the liquid form decreased steatorrhea more than powder bacterial lipase (P = 0.017 and 0.057, respectively). Coefficients of fat absorption with 300,000 IU of powder bacterial lipase correlated (r2 = 0.79; P < 0.001) with increasing proportions of fat calories in diets. CONCLUSIONS: Liquid bacterial lipase decreases steatorrhea more than powder, and 300,000 IU of powder bacterial lipase ingested with high-fat meals corrects canine pancreatic steatorrhea. The combination of adequate mixing of small amounts (milligrams) of bacterial lipase and high-fat meals abolishes canine steatorrhea and may abolish human pancreatic steatorrhea. (Gastroenterology 1997 Jun;112(6):2048-55) 相似文献
6.
Acoustic emission from renal calculi irradiated by a pulsed dye laser was observed in vivo and investigated in vitro. A number
of acoustic frequency spectra were recorded from laser exposure of ureteric calculi, calcified arterial wall and bladder tissue.
Although differences were observed between spectra, these did not depend on target material. Investigations with model targets
suggested that variations in acoustic emission were caused by fluctuations in the strength of the laser plasma, due to changes
in the local surface absorption of laser light, and by alterations in the relative orientation of laser fibre, target and
transducer. Interaction between lasers and stones is reviewed and discussed. 相似文献
7.
8.
R Wickham 《Oncology nursing forum》1989,16(4):563-574
The consequences of inadequately controlled chemotherapy-related nausea and vomiting range from minor discomfort to dose-limiting toxicity. Physical complications may occur secondary to protracted nausea and emesis. Furthermore, patient discomfort may be reflected in altered quality of life or noncompliance with therapy. As a primary caregiver, the nurse takes an active role in collaborating with the physician to prevent and/or minimize these side effects and their sequelae. An understanding of the patterns, mechanisms, and risk of chemotherapy-related nausea and vomiting is crucial to providing optimal patient care. Concepts of drug therapy are emphasized as the cornerstone of antiemetic management. 相似文献
9.
A randomized controlled trial of electromagnetic therapy in the primary care management of venous leg ulceration 总被引:1,自引:1,他引:0
OBJECTIVE: The aim was to establish the potential efficacy, tolerabilityand side-effect profile of electromagnetic therapy as an adjunctto conventional dressings in the treatment of venous leg ulcers. METHOD: A prospective, randomized, double blind controlled clinicaltrial was carried out in a dedicated leg ulcer clinic basedin one urban general practice. Nineteen patients with leg ulcersof confirmed venous aetiology were assessed. The main outcomemeasures were rate and scale of venous leg ulcer healing, changesin patient-reported pain levels, quality of life, degree ofmobility, side effect profile and acceptability to patientsand staff. RESULTS: Sixty-eight per cent of patients attending this dedicated clinicachieved improvements in the size of their ulcer (4, 21%, healedfully) and in reduced pain levels (P < 0.05) during the trial,despite the chronicity of ulcer histories. Patients treatedwith electromagnetic therapy at 800 Hz were found at day 50to have significantly greater healing (P < 0.05) and paincontrol (P < 0.05) than placebo therapy or treatment with600 Hz. All patients reported improved mobility at the end ofthe study. The electromagnetic therapy was well tolerated bypatients, with no differences between groups in reporting adverseevents, and proved acceptable to staff. CONCLUSION: Despite the small numbers in this pilot study, electromagnetictherapy provided significant gains in the healing of venousleg ulcers and reduction in pain. Keywords. Electromagnetic therapy, RCT, leg ulcers, primary care. 相似文献
10.
Summary Influenza A2/Singapore and A2/Hong Kong virus strains formed plaques in monolayers of monkey kidney and dog kidney cells. Using a serum-free overlay containing Earle's balanced salt solution with 1% lactalbumin hydrolysate, 1.4 g/1 sodium bicarbonate and 0.6% agarose, plaque formation occurred in 4–7 days. By incorporating compound in the overlay, plaque inhibition was demonstrated by Amantadine, Rimantadine and the isoquinoline derivatives designated Pfizer UK-2054, UK-2617, UK-2762 and UK-2888. 相似文献