全文获取类型
收费全文 | 248篇 |
免费 | 46篇 |
专业分类
儿科学 | 2篇 |
妇产科学 | 4篇 |
基础医学 | 11篇 |
临床医学 | 4篇 |
内科学 | 11篇 |
皮肤病学 | 213篇 |
神经病学 | 11篇 |
特种医学 | 2篇 |
外科学 | 5篇 |
综合类 | 7篇 |
预防医学 | 6篇 |
药学 | 10篇 |
中国医学 | 1篇 |
肿瘤学 | 7篇 |
出版年
2023年 | 2篇 |
2022年 | 1篇 |
2021年 | 4篇 |
2020年 | 40篇 |
2019年 | 13篇 |
2018年 | 4篇 |
2017年 | 18篇 |
2016年 | 14篇 |
2015年 | 15篇 |
2014年 | 12篇 |
2013年 | 4篇 |
2012年 | 12篇 |
2011年 | 22篇 |
2010年 | 21篇 |
2009年 | 3篇 |
2008年 | 20篇 |
2007年 | 13篇 |
2006年 | 4篇 |
2005年 | 8篇 |
2004年 | 4篇 |
2003年 | 5篇 |
2002年 | 9篇 |
2001年 | 5篇 |
2000年 | 1篇 |
1999年 | 4篇 |
1997年 | 4篇 |
1996年 | 4篇 |
1994年 | 2篇 |
1993年 | 3篇 |
1992年 | 1篇 |
1991年 | 2篇 |
1990年 | 5篇 |
1989年 | 5篇 |
1988年 | 2篇 |
1986年 | 4篇 |
1984年 | 1篇 |
1980年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
排序方式: 共有294条查询结果,搜索用时 31 毫秒
1.
2.
3.
4.
5.
Jushya Bhatia Ankur Sarin Uwe Wollina Torello Lotti Alexander A. Navarini Simon M. Mueller Stephan Grabbe Joachim Saloga Ghasem R. Rokni Mohamad Goldust 《Contact dermatitis》2020,83(3):179-181
The resistant and recalcitrant nature of severe allergic contact dermatitis (ACD) makes its management challenging. With advances in the understanding of the cellular and molecular pathogenesis of ACD, newer therapeutic targets are becoming apparent. In particular, the use of biologics has gained momentum, given the specificity of their action. This article aims to review the presently available data on the use of biologics in ACD. English-language–based literature available on the use of biological therapy was thoroughly probed in the following databases as on October 14, 2019: PubMed, Google Scholar, The Cochrane library, Embase, Scopus, and EBSCO. The following keywords were used: “contact dermatitis”, “allergens”, “delayed-type hypersensitivity reaction”, “biologics”, “biological therapy”, “monoclonal antibodies”, “patch testing”, “TNF-α inhibitors”, “infliximab”, “adalimumab”, “etanercept”, “dupilumab”, “omalizumab”, “secukinumab”, “ustekinumab”, “rituximab”. 相似文献
6.
Malignant melanoma is an oncologic disease, whose current management among others includes surgical and immunological therapy. According to the current recommendations of the American Joint Committee on Cancer, the surgical excision of the primary tumor should be performed in two operative sessions, which has several consequences. The following paper will present and discuss six cases of pigmented lesions and the advantages of the one‐step melanoma surgery in their management. 相似文献
7.
Muhammad Saaiq Iris Zalaudek Babar Rao Young Lee Lidia Rudnicka Joanna Czuwara Roberta Giuffrida Uwe Wollina Mohammad Jafferany Torello Lotti Stephan Grabbe Mohamad Goldust 《Dermatologic therapy》2020,33(4)
Melanoma constitutes one of the most sinister and troublesome malignancies encountered by humanity. Generally, the diagnosis of advanced melanoma connotes a grave prognosis, prompting a sense of looming threat of death, however, the early‐stage detected disease responds well to robust treatment resulting in reasonable survivorship. Scalp melanomas are even more troublesome, because they typically exhibit more aggressive biologic behavior and are often diagnosed at a late stage. This review tries to comprehensively highlight the various diagnostic, therapeutic, and outcome aspects of scalp melanomas. The literature research includes peer‐reviewed articles (clinical trials or scientific reviews). Studies were identified by searching electronic databases (MEDLINE and PubMed) till May 2020 and reference lists of respective articles. Only articles published in English language were included. 相似文献
8.
Rachita Dhurat Aseem Sharma Lidia Rudnicka George Kroumpouzos Martin Kassir Hassan Galadari Uwe Wollina Torello Lotti Masa Golubovic Iva Binic Stephan Grabbe Mohamad Goldust 《Dermatologic therapy》2020,33(3)
Androgenetic alopecia (AGA) is a multifactorial disease that carries a significant psychological burden with it. Dihydrotestosterone, the main pathogenic androgen in AGA, is produced by conversion of testosterone, which is catalyzed by the 5‐alpha reductase (5‐AR) isoenzyme family. Finasteride and dutasteride are inhibitors of these enzymes. Finasteride, which is a single receptor 5‐alpha reductase inhibitor (5‐ARI), acts by blocking dihydrotestosterone (DHT). Dutasteride, a dual receptor DHT blocker, has a higher potency than its predecessor, finasteride. This review corroborates the evidence of superiority of dutasteride over finasteride, and its comparable safety profile concerning fertility, teratogenicity, neurotoxicity, and hepatotoxicity. 相似文献
9.
Michael Tirant Jacopo Scala Mohammad Jafferany Mohamad Goldust Roxanna Sadoughifar Torello Lotti 《Dermatologic therapy》2020,33(3)
The aim of this study was to investigate the relationship between the ABO blood, groups and triggers, including food, of psoriasis. A total of 683 psoriasis patients were included in the retrospective study and divided into groups based on their blood group (ABO). Patients were asked to complete a series questions related to the effect of certain foods and other triggers on their psoriasis symptoms. A significant difference between blood groups and the effect of different triggers on the initiation and exacerbation of psoriasis was noted. Furthermore, similarities in response were found between blood groups sharing the same alleles, such as A and AB, or B and AB. Results from this study suggest a link between blood group type and triggering factors of psoriasis. The data show that different blood groups are significantly more likely to have different initiating and exacerbating triggers for psoriasis. 相似文献
10.
Eleonora Rodighiero Mariabeatrice Bertolani Roberta Saleri Giuseppe Pedrazzi Torello Lotti Claudio Feliciani Francesca Satolli 《Dermatologic therapy》2020,33(3)
Acne is a chronic inflammatory disease affecting sebaceous gland follicles. Lately, acne has considered an insulin‐like growth factor‐1 (IGF‐1) mediated disease. Recent research demonstrated that IGF‐1 levels decrease after 3 months of isotretinoin. The purpose of our study is evaluating the influence of acne treatments on IGF‐1 serum levels. Forty‐six subjects with acne vulgaris aged 14 to 30 years were subdivided into three groups according to their severity of acne and treated following the European Dermatology Forum guidelines. IGF‐1 was measured in patients before and after the treatment and then compared to the IGF‐1 of a healthy population of the same age. IGF‐1 resulted higher in patients than in controls but there was not a statistically significant variation after treatment. To the best of our knowledge, this is the first study evaluating the influence of topical and systemic acne treatment on IGF‐1 serum levels. In contrast with the literature, our results suggest that common therapies for acne are not able to significantly modify IGF‐1 serum levels. 相似文献