全文获取类型
收费全文 | 430篇 |
免费 | 24篇 |
专业分类
儿科学 | 4篇 |
妇产科学 | 3篇 |
基础医学 | 55篇 |
临床医学 | 61篇 |
内科学 | 88篇 |
皮肤病学 | 2篇 |
神经病学 | 56篇 |
特种医学 | 7篇 |
外科学 | 68篇 |
综合类 | 1篇 |
一般理论 | 2篇 |
预防医学 | 59篇 |
药学 | 15篇 |
肿瘤学 | 33篇 |
出版年
2023年 | 3篇 |
2022年 | 3篇 |
2021年 | 12篇 |
2020年 | 8篇 |
2019年 | 10篇 |
2018年 | 7篇 |
2017年 | 18篇 |
2016年 | 5篇 |
2015年 | 20篇 |
2014年 | 28篇 |
2013年 | 29篇 |
2012年 | 52篇 |
2011年 | 47篇 |
2010年 | 30篇 |
2009年 | 27篇 |
2008年 | 33篇 |
2007年 | 19篇 |
2006年 | 21篇 |
2005年 | 30篇 |
2004年 | 7篇 |
2003年 | 16篇 |
2002年 | 8篇 |
2001年 | 1篇 |
1999年 | 3篇 |
1998年 | 5篇 |
1997年 | 4篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1993年 | 2篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1990年 | 1篇 |
排序方式: 共有454条查询结果,搜索用时 31 毫秒
1.
Helen J. Michielsen Marcel A. Croon Tineke M. Willemsen Jolanda De Vries Guus L. Van Heck 《Stress and health》2007,23(2):121-130
The main objective of this study was to examine the psychosocial stress model developed by Taylor and Aspinwall with emotional exhaustion as the outcome variable. Respondents, 409 men and 346 women, who had a paid job for at least 20 hours per week, completed questionnaires concerning demographic variables, personality, temperament, work pressure, workload, perceived social support, appraisal, coping, and emotional exhaustion. Structural equation analyses provided only partial support for the validity of the model. First, on theoretical and statistical grounds, one more path linking external resources to social support was added. Second, contrary to expectations, coping styles did not predict emotional exhaustion. To conclude, when coping is measured retrospectively, it does not add to our understanding of emotional exhaustion. It is suggested that future studies should be longitudinal and include objective measures of stressors and psychosocial health outcomes in addition to self‐reports. Copyright © 2007 John Wiley & Sons, Ltd. 相似文献
2.
3.
4.
Participation of older people in designing and improving the care and services provided in residential care settings is limited. Traditional forms of democratic representation, such as client councils, and consumer models are management-driven. An alternative way of involving older people in the decisions over their lives, grounded in notions of care ethics and deliberative democracy, was explored by action research. In line with this tradition older people engage in collective action to enhance the control over their lives and those of others. In this article the theoretical background of altruistic action is presented and illustrated by a case example of a group of older women who changed the food policies within their residential home. Altruistic action is the joint and coordinated action by a group of clients based on their agenda. Such action is given in by a shared dissatisfaction and search for connections. Altruistic action may enhance the sense of self, belonging and ownership, and create a transformative movement enhancing the wellbeing and community life in residential settings. 相似文献
5.
6.
7.
Tineke van de Weijer Esther Phielix Lena Bilet Evan G. Williams Eduardo R. Ropelle Alessandra Bierwagen Roshan Livingstone Peter Nowotny Lauren M. Sparks Sabina Paglialunga Julia Szendroedi Bas Havekes Norman Moullan Eija Pirinen Jong-Hee Hwang Vera B. Schrauwen-Hinderling Matthijs K.C. Hesselink Johan Auwerx Michael Roden Patrick Schrauwen 《Diabetes》2015,64(4):1193-1201
Recent preclinical studies showed the potential of nicotinamide adenine dinucleotide (NAD+) precursors to increase oxidative phosphorylation and improve metabolic health, but human data are lacking. We hypothesize that the nicotinic acid derivative acipimox, an NAD+ precursor, would directly affect mitochondrial function independent of reductions in nonesterified fatty acid (NEFA) concentrations. In a multicenter randomized crossover trial, 21 patients with type 2 diabetes (age 57.7 ± 1.1 years, BMI 33.4 ± 0.8 kg/m2) received either placebo or acipimox 250 mg three times daily dosage for 2 weeks. Acipimox treatment increased plasma NEFA levels (759 ± 44 vs. 1,135 ± 97 μmol/L for placebo vs. acipimox, P < 0.01) owing to a previously described rebound effect. As a result, skeletal muscle lipid content increased and insulin sensitivity decreased. Despite the elevated plasma NEFA levels, ex vivo mitochondrial respiration in skeletal muscle increased. Subsequently, we showed that acipimox treatment resulted in a robust elevation in expression of nuclear-encoded mitochondrial gene sets and a mitonuclear protein imbalance, which may indicate activation of the mitochondrial unfolded protein response. Further studies in C2C12 myotubes confirmed a direct effect of acipimox on NAD+ levels, mitonuclear protein imbalance, and mitochondrial oxidative capacity. To the best of our knowledge, this study is the first to demonstrate that NAD+ boosters can also directly affect skeletal muscle mitochondrial function in humans. 相似文献
8.
Losing connections and receiving support to reconnect: experiences of frail older people within care programmes implemented in primary care settings
下载免费PDF全文
![点击此处可从《International journal of older people nursing》网站下载免费的PDF全文](/ch/ext_images/free.gif)
9.
Martinez-Gomez D Gomez-Martinez S Ruiz JR Diaz LE Ortega FB Widhalm K Cuenca-Garcia M Manios Y De Vriendt T Molnar D Huybrechts I Breidenassel C Gottrand F Plada M Moreno S Ferrari M Moreno LA Sjöström M Marcos A;HELENA Study Group 《Atherosclerosis》2012,221(1):260-267
ObjectiveAtherogenesis involves an inflammatory process that occurs early in life even though clinical symptoms are not observed until adulthood. Two important protective factors for low-grade inflammation may be physical activity (PA) and fitness. We examined the independent associations of objective and subjective measurements of PA and fitness with low-grade inflammation in European adolescents.MethodsA total of 1045 adolescents, aged from 12.5 to 17.5 years old from 10 European cities, were selected from the HELENA-Cross-Sectional Study. Objectively-measured and self-reported PA variables were obtained by accelerometry and the International PA Questionnaire for Adolescents, respectively. Overall, cardiorespiratory, muscular and motor fitness variables were assessed by standardized field-based fitness tests and the International Fitness Scale. C-reactive protein (CRP), complement factors 3 (C3) and 4 (C4), interleukin-6 and TNF-α inflammatory markers were measured.ResultsObjectively-measured vigorous PA was inversely associated with C3 (β = ?0.094, P = 0.021) but it did not remain significant after any objective fitness indicator was included in the model. Other objectively measured or self-reported assessments of PA were not significantly associated with inflammatory markers. All objective measures of fitness were inversely associated with CRP, C3 and C4, whereas only self-reported motor fitness remained significantly associated with C3, C4 and TNF-α. All these observations were independent of age, sex, city and body mass index or waist circumference.ConclusionHigh PA in adolescence may play an indirect role on lessening low-grade inflammation through improvements in fitness. 相似文献
10.
Luai Awad Ahmed Jacqueline R Center Åshild Bjørnerem Dana Bluic Ragnar M Joakimsen Lone Jørgensen Haakon E Meyer Nguyen D Nguyen Tuan V Nguyen Tone K Omsland Jan Størmer Grethe S Tell Tineke ACM van Geel John A Eisman Nina Emaus 《Journal of bone and mineral research》2013,28(10):2214-2221
The risk of subsequent fracture is increased after initial fractures; however, proper understanding of its magnitude is lacking. This population‐based study examines the subsequent fracture risk in women and men by age and type of initial incident fracture. All incident nonvertebral fractures between 1994 and 2009 were registered in 27,158 participants in the Tromsø Study, Norway. The analysis included 3108 subjects with an initial incident fracture after the age of 49 years. Subsequent fracture (n = 664) risk was expressed as rate ratios (RR) and absolute proportions irrespective of death. The rates of both initial and subsequent fractures increased with age, the latter with the steepest curve. Compared with initial incident fracture rate of 30.8 per 1000 in women and 12.9 per 1000 in men, the overall age‐adjusted RR of subsequent fracture was 1.3 (95% CI, 1.2–1.5) in women, and 2.0 (95% CI, 1.6–2.4) in men. Although the RRs decreased with age, the absolute proportions of those with initial fracture who suffered a subsequent fracture increased with age; from 9% to 30% in women and from 10% to 26% in men, between the age groups 50–59 to 80+ years. The type of subsequent fracture varied by age from mostly minor fractures in the youngest to hip or other major fractures in the oldest age groups, irrespective of type and severity of initial fracture. In women and men, 45% and 38% of the subsequent hip or other major fractures, respectively, were preceded by initial minor fractures. The risk of subsequent fracture is high in all age groups. At older age, severe subsequent fracture types follow both clinically severe and minor initial incident fractures. Any fragility fracture in the elderly reflects the need for specific osteoporosis management to reduce further fracture risk. © 2013 American Society for Bone and Mineral Research. 相似文献