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排序方式: 共有279条查询结果,搜索用时 15 毫秒
1.
Hideki SATO Kazuyuki KANEMASA Masamichi TANINO Tsugihiro KIMURA Kenji MAENOU Shouji MITSUFUJI Kyouhei MARUYAMA Tadashi KODAMA Kei KASHIMA Naoki TERAMAE Susumu FUKUI Keizo KAGAWA 《Digestive endoscopy》1996,8(1):41-45
Abstract: Biliobiliary fistula is a rare clinical entity. The case of a 72 year old female, who presented with epigastric pain and jaundice, is detailed herein. Endoscopic retrograde cholangiopancreatography (ERCP) revealed two stones, one each in the common bile duct and the gallbladder. Continuous endoscopic nasobiliary drainage (ENBD) was performed to relieve obstructive jaundice. Further study with contrast medium administered via the ENBD tube revealed a fistula between the neck of the gallbladder and the common bile duct. The cystic duct was intact. A stone was considered to have migrated into the common bile duct through the fistula. A diagnosis of biliobiliary fistula, Corlette type I was made. However, in this particular case, a biliobiliary fistula was noted at a site below the junction of the cystic duct and common bile duct. Removal of the gallbladder stones was followed by cholecystectomy. The common bile duct was then repaired by utilizing a T-tube. No evidence of malignancy was recognized in the resected gallbladder specimen. In the one year to date since surgery, the patient has been asymptomatic and without signs of biliary disease. 相似文献
2.
TADASHI OHKUBO TAKAKO OSANAI KAZUNOBU SUGAWARA MASAYUKI ISHIDA KOICHI OTANI KAZUO MIHARA NORIO YASUI 《The Journal of pharmacy and pharmacology》1995,47(4):340-344
A high-performance liquid chromatographic (HPLC) assay was developed for the determination of trazodone and its metabolite, 1-m-chlorophenylpiperazine (m-CPP), in plasma. The high level of trazodone in plasma was detected by ultraviolet absorbance at 254 nm and the low level of m-CPP in plasma was detected by coulometric electrochemical detection at 840 mV on the series arrangement of two detectors. Pilsicainide as an internal standard for both compounds was monitored by both detectors. Trazodone and m-CPP in plasma were extracted by a rapid and simple procedure based on CN bonded-phase extraction, and C8 reversed-phase HPLC separation. Determination was possible for trazodone in the concentration range 100–2000 ng mL?1 and for m-CPP in the concentration range 5–100 ng mL?1. The recoveries of trazodone and m-CPP added to plasma were 81·0–84·2 and 68·0–73·2%, respectively, with coefficients of variation of less than 7·3 and 8·2%, respectively. The method is applicable to high level monitoring of trazodone and low level monitoring of m-CPP in plasma of healthy volunteers and patients treated with trazodone. 相似文献
3.
Shouji Iwatsuki Hideo Kasahara Yuya Yamashita 《Macromolecular chemistry and physics.》1967,104(1):254-262
RANEY metals (Ni, Fe, Co), URUSHIBARA metals (Ni, Co) and ULIMANN cu initiate the polymerization of methylmethacrylate. Diamines, diols or organic halides enhance their reactivity. In the presence of CCl4, the polymerization rate (Rp) is proportional to the square root of the amount of both metals and CCl4, and to the first power of the monomer concentration, but Rp becomes constant and independent of the concentration of CCl4 when there is a great excess of CCl4. We concluded that this polymerization follows the free radical mechanism and the participation of a zero-valent metal atom in the initiation reaction including complex formation between metal and CCL4 is suggested. 相似文献
4.
老年人的发病特点及预防 总被引:1,自引:0,他引:1
目的:通过对老年人健康状况的调查,总结老年人发病特点,提出预防和治疗措施,以期延长老年人的寿命,提高老年人生活质量。方法:将780铝调查对象集中於医院,按规范化标准作体格检查,并由主任医师作结论。结果:高血压、心脑血管道在病、白内障、前列腺疾患、肺气肿及糖尿病等为老年人常见病。结论:定期体检及提高基知务人璋减少和预防老年病的重要手段。 相似文献
5.
Shuichi Adachi Ken Kawamura Shouji Yoshida Kazuo Takemoto 《International archives of occupational and environmental health》1992,63(8):553-557
Summary We compared the potential of asbestos and man-made fibers to attack DNA by the determination of the yield of 8-hydroxy-2-deoxyguanosine (8-OH-dGuo) under several in vitro conditions. Asbestos induced 6.6–99.8 of 8-OH-dGuo per 105 dGuo in calf thymus DNA after 20 h of incubation, while the levels of 8-OH-dGuo in man-made fibers were low (3.6–9.4). The amounts of 8-OH-dGuo were strongly stimulated by the addition of H2O2 in asbestos, but not in man-made fibers. However, the yield of 8-OH-dGuo was induced more than that with asbestos by the further addition of FeSO4 in attapulgite, fiberglass, potassium titanate whisker, and metaphosphate polymer. The addition of ethylene diamine tetraacetic acid (EDTA) promoted the induction of 8-OH-dGuo with asbestos and H2O2. The effects of mannitol (known as a hydroxy radical scavenger) were not dramatic on 8-OH-dGuo induction by all fibers except fiberglass and basic magnesium sulfate whisker, which induced higher amounts after mannitol addition than in these fibers and H2O2. Therefore, it was suggested that asbestos could damage DNA, resulting in 8-OH-dGuo as a cause of point mutation, and also several types of manmade fibers had similar effects to asbestos under certain conditions. 相似文献
6.
Induction of apoptosis in multi-drug resistant (MDR) human glioblastoma cells by SN-38, a metabolite of the camptothecin derivative CPT-11 总被引:5,自引:0,他引:5
Shouji Nakatsu S. Kondo Yasuko Kondo Dali Yin John W. Peterson Rami Kaakaji Tatsuo Morimura Haruhiko Kikuchi Juji Takeuchi Gene H. Barnett 《Cancer chemotherapy and pharmacology》1997,39(5):417-423
The overexpression of the multidrug resistance (mdr1) gene and its product, P-glycoprotein (P-gp), is thought to limit the successful chemotherapy of human tumors. Recent studies
demonstrate that SN-38, a metabolite of the camptothecin (CPT) derivative CPT-11, has antitumor effects on several tumors,
but the mechanisms responsible for its cytotoxicity remain unclear. We therefore determined whether SN-38 has cytotoxic effects
on MDR human glioblastoma GB-1 cells and non-MDR human glioblastoma U87-MG cells. Furthermore, we determined what role SN-38
plays in the induction of cytotoxicity in these tumor cells. In this study, we demonstrated that SN-38 had significantly stronger
antitumor effects on GB-1 and U-87MG cells than did CPT (P<0.01 and P<0.05, respectively). In addition, findings obtained using a DNA fragmentation assay, Hoechst 33258 staining, in situ end-labeling
and cell cycle analysis demonstrated that SN-38 induced apoptosis in these tumors. Our results suggest that SN-38 has a stronger
antitumor effect on malignant glioma cells regardless of MDR expression than does CPT, and therefore can be considered a new
chemotherapeutic agent potentially effective in the treatment of human primary or recurrent malignant gliomas resistant to
chemotherapy.
Received: 6 October 1995/Accepted 29 June 1996 相似文献
7.
比较西门子炫速双源CT的3种不同扫描模式对冠脉桥成像质量及辐射剂量的影响。选择我院搭桥术后随访72例患者为研究对象,所有患者心率≤65次/min且节律规则,随机分为3组,分别采用大螺距扫描、前门控序列扫描及回顾性心电门控扫描3种不同的西门子炫速双源CT扫描模式评价患者的冠状动脉桥血管的通畅性及图像质量,并比较各组的辐射剂量。前门大螺距扫描模式的有效辐射剂量明显低于前门控序列扫描和回顾性心电门控扫描模式,具有显著性差异(F=118.21,P<0.05)。3种双源CT扫描模式的图像主观质量评分无显著性差异(H=0.531,P>0.05)。西门子炫速双源CT前门控大螺距扫描模式不仅能实现心脏冠状动脉低剂量的扫描,还能获得较好的图像质量,可有效用于评估冠状动脉搭桥术后桥血管的通畅性。 相似文献
8.
Shinichi Niwano Hidehira Fukaya Masaru Yuge Ryuta Imaki Shouji Hirasawa Takeshi Sasaki Yoshihiro Yumoto Takayuki Inomata Tohru Izumi 《Circulation journal》2008,72(2):268-273
BACKGROUND: Ventricular tachyarrhythmias (VT/VF) are 1 of the most important factors determining the prognosis of patients with heart failure (HF). Although priority is given to implantable cardioverter defibrillator (ICD) therapy for the prevention of sudden cardiac death, electrophysiologic-study (EPS)-guided preventive therapy could be important for reducing the number of cardiac events. METHODS AND RESULTS: Of 864 patients with a history of HF, an EPS was performed in 168 and 121 had inducible VT/VF. Under the basic therapy of an ICD, additional catheter ablation was attempted for 95 of 124 monomorphic VT foci in 74 patients, and 78 of the VT were successfully ablated. The prognoses were compared among 5 patient groups with different results for the EPS and catheter ablation: (1) success group (n=43), (2) failure group (n=15), (3) not attempted group (n=16), (4) VF group (n=47), and (5) no inducible VT/VF group. During a follow-up period of 31+/-22 months, the incidence of VT/VF was lower in the success and no inducible VT/VF groups than in the other groups (p=0.0018), although a significant difference was not observed for the total deaths. CONCLUSION: EPS-guided preventive therapy using an ICD and catheter ablation can be useful, at least for the reduction of arrhythmic events in patients with HF. 相似文献
9.
10.
Gastric cancer with metastasis to the gingiva 总被引:3,自引:0,他引:3
Shimoyama S Seto Y Aoki F Ogawa T Toma T Endo H Itouji T Kaminishi M 《Journal of gastroenterology and hepatology》2004,19(7):831-835
The present case report describes a gastric cancer which showed unusual metastasis in the oral region. A 56-year-old male patient underwent total gastrectomy and splenectomy due to advanced gastric cancer in the upper third of the stomach. Fifteen months later, he presented with anorexia and gingival swelling of durations of approximately 3 and 1 month, respectively. The gastric tumor was histologically a signet ring cell and a poorly differentiated cancer with a moderate degree of vascular invasion. Biopsy specimens from the gingival tumor revealed a signet ring cell cancer. Other metastatic sites were the brain, limb bones and abdominal lymph nodes. A bone scintigram revealed an abnormal uptake in the limb bones, while it did not exhibit any abnormality in the oral region. Correlation between the histology of the gingival tumor with that of the gastric cancer, as well as the absence of a gingival tumor at the time of prior gastrectomy, led to a diagnosis that the gingival tumor was a metastasis from gastric cancer. Gastric cancer metastasizing to the oral region, either the osseus or the oral soft tissue, is very rare. Although it cannot be proved without an autopsy, negative findings in the mandible by bone scanning in the present case suggest that direct gingival metastasis can be considered, rather than mandibular metastasis involving the gingiva. Hematogenous spread could be a mechanism of metastasis for this unusual tumor. 相似文献