Granuloma anulare disseminatum – erfolgreiche Therapie mit Fumarsäureester

A 64-year old female patient was treated for a therapy-resistant generalized granuloma annulare with fumaric acid esters (Fumaderm initial). One week following begin of therapy with an initial dose of 30 mg per day, the papules had regressed significantly. A 6-week therapy with a final dose of 90 mg Fumaderm initial per day led to a nearly complete healing of the illness.     

Contact allergy to dexpanthenol

Eleven cases of contact allergy to dexpanthenol are reported (5 females, 6 males; mean age 62.4 years). Five patients suffered from a leg ulcer and/or stasis dermatitis. In five patients the sensitization occurred after the application of dexpanthenol-containing ointments to the face. Only one patient did not show sensitization to other common allergens. Three patients were sensitive to wool wax alcohols, which are present in a commonly used product. Dexpanthenol seems to be a rare sensitizer, yet clinically most relevant for patients with stasis dermatitis and multiple allergies.     

Contact allergy caused by polidocanol (thesit)

The paper contains a report on 16 patients with positive patch test reactions to polidocanol (11 women, 3 men, 2 children). The majority of the patients suffered from chronic dermatitis and had further contact sensitizations to antibiotics and to vehicle constituents. The clinical relevance of positive reactions to polidocanol remained unclear in many cases. A positive reaction was reproduced in only two of six cases at a late follow-up examination. A repeated open application test in the antecubital space with two polidocanol preparations for topical application was strongly positive in one case and doubtful in another case. In view of the wide use of preparations containing polidocanol literature reports and our own observations lead us to recommend patch testing with polidocanol in the drug series is recommended for all patients with chronic dermatitis, particularly those with lower leg and perianal dermatitis.     

Efficacy of skin barrier creams

An animal model for the evaluation of skin protective creams against chemical irritants is described. The irritants were applied daily for 2 weeks to shaved back skin of young guinea pigs: sodium tauryl sulphate (5% aq.: 30 min), sodium hydroxide (0,5% aq.; 2 min). and toluene (20'i. eth.; 2 mint. "The harrier cream was applied 2 h prior to and immediately after exposure to the irritant. Control animals were treated with the irritant only. The irritant reaction was scored on a 4–point scale for erythema and quantified with regard to transepidennal water loss (TEWL) by evaporime-try and skin blood flow volume (BFV) by laser Doppler velocimetry. A total of 90 guinea pigs, consisting of" individual panels of 5 to 10 animals, was tested. While one barrier cream (Slokoderm) significantly suppressed the irritation due 10 sodium lauryl sulphate and toluene, the other (Contra-Alkalh failed to do so and even aggravated the response, which was particularly evident with sodium hydroxide. This model may be useful in developing more effective barrier creams.     

Contact allergy to Kathon CG

Among 671 consecutive patients who underwent the patch test with Kathon CG (100 ppm active ingredient), 23 (3.43%) showed a positive reaction (87% females). In 52.2% of these cases the clinical relevance of these reactions was considered to be proven. Most of the patients were suffering from contact dermatitis of the face or hands. Cosmetics were found to be the major cause of sensitization. In view of the widespread use of this preservative, testing with Kathon CG is recommended in all cases of contact dermatitis.     

Latexallergie

Ohne Zusammenfassung