排序方式: 共有30条查询结果,搜索用时 328 毫秒
1.
2.
3.
4.
5.
Victor Bobée Philippe Ruminy Vinciane Marchand Pierre-Julien Viailly Ahmad Abdel Sater Liana Veresezan Fanny Drieux Caroline Bérard Elodie Bohers Sylvain Mareschal Sydney Dubois Jean-Philippe Jais Karen Leroy Martin Figeac Jean-Michel Picquenot Thierry J. Molina Gilles Salles Corinne Haioun Fabrice Jardin 《The Journal of molecular diagnostics : JMD》2018,20(2):266
6.
Sydney Dubois Philippe Ruminy Elodie Bohers PierreJulien Viailly Liana Veresezan JeanMichel Picquenot Victor Bobe Mathieu Viennot Dominique Penther Vincent Camus Catherine Thieblemont Camille Pouaty Herv Tilly Fabrice Jardin 《Clinical Case Reports》2021,9(8)
Synchronous Hodgkin Lymphoma and Primary Mediastinal B‐cell Lymphoma is possible, with molecular analyses proving the absence of clonal filiation between both entities. This suggests a common etiology but the existence of two divergent clones. 相似文献
7.
Fanny Drieux Philippe Ruminy Vincent Sater Vinciane Marchand Virginie Fataccioli Marie-Delphine Lanic Mathieu Viennot Pierre-Julien Viailly Nouhoum Sako Cyrielle Robe Aurélie Dupuy David Vallois Liana Veresezan Elsa Poullot Jean-Michel Picquenot Céline Bossard Marie Parrens François Lemonnier Philippe Gaulard 《The Journal of molecular diagnostics : JMD》2021,23(8):929-940
8.
Laurent Davin Alain Nchimi Federica Ilardi Raluca Dulgheru Stella Marchetta Olivier Gach Patrick Marechal Sara Cimino Pierre-Julien Bruyère Andreas Georgiopoulos John Epoh Dibato Gessica dAmico Maurizio Galderisi Valentina Parisi Cécile Oury Patrizio Lancellotti 《JACC: Cardiovascular Imaging》2019,12(1):213-214
9.
Oncogenic events rather than antigen selection pressure may be the main driving forces for relapse in diffuse large B‐cell lymphomas
下载免费PDF全文
![点击此处可从《American journal of hematology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
David Rizzo Pierre‐Julien Viailly Sylvain Mareschal Elodie Bohers Jean‐Michel Picquenot Dominique Penther Sydney Dubois Vinciane Marchand Philippe Bertrand Catherine Maingonnat Pascaline Etancelin Jean Feuillard Christian Bastard Hervé Tilly Fabrice Jardin Philippe Ruminy 《American journal of hematology》2017,92(1):68-76
Little is known on the phylogenetic relationship between diagnostic and relapse clones of diffuse large B‐cell lymphoma (DLBCL). We applied high throughput sequencing (HTS) of the VDJ locus of Immunoglobulin heavy chain (IGHV) on 14 DLBCL patients with serial samples, including tumor biopsies and/or peripheral blood mononuclear cells (PBMC). Phylogenetic data were consolidated with targeted sequencing and cytogenetics. Phylogeny clearly showed that DLBCL relapse could occur according either an early or a late divergent mode. These two modes of divergence were independent from the elapsed time between diagnosis and relapse. We found no significant features for antigen selection pressure in complementary determining region both at diagnosis and relapse for 9/12 pairs and a conserved negative selection pressure for the three remaining cases. Targeted HTS and conventional cytogenetics revealed a branched vs. linear evolution for 5/5 IGHV early divergent cases, but unexpected such “oncogenetic” branched evolution could be found in at least 2/7 IGHV late divergent cases. Thus, if BCR signaling is mandatory for DLBCL emergence, oncogenetic events under chemotherapy selection pressure may be the main driving forces at relapse. Finally, circulating subclones with divergent IGHV somatic hypermutations patterns from initial biopsy could be detected in PBMC at diagnosis for 4/6 patients and, for two of them, at least one was similar to the ones found at relapse. This study highlights that oncogenetic intraclonal diversity of DLBCL should be evaluated beyond the scope a single biopsy and represents a rationale for future investigations using peripheral blood for lymphoid malignancies genotyping. Am. J. Hematol. 92:68–76, 2017. © 2016 Wiley Periodicals, Inc. 相似文献
10.
Recurrent mutations of the exportin 1 gene (XPO1) and their impact on selective inhibitor of nuclear export compounds sensitivity in primary mediastinal B‐cell lymphoma
下载免费PDF全文
![点击此处可从《American journal of hematology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Fabrice Jardin Anais Pujals Laura Pelletier Elodie Bohers Vincent Camus Sylvain Mareschal Sydney Dubois Brigitte Sola Marlène Ochmann François Lemonnier Pierre‐Julien Viailly Philippe Bertrand Catherine Maingonnat Alexandra Traverse‐Glehen Philippe Gaulard Diane Damotte Richard Delarue Corinne Haioun Christian Argueta Yosef Landesman Gilles Salles Jean‐Philippe Jais Martin Figeac Christiane Copie‐Bergman Thierry Jo Molina Jean Michel Picquenot Marie Cornic Thierry Fest Noel Milpied Emilie Lemasle Aspasia Stamatoullas Peter Moeller Martin J.S Dyer Christer Sundstrom Christian Bastard Hervé Tilly Karen Leroy 《American journal of hematology》2016,91(9):923-930
Primary mediastinal B‐cell lymphoma (PMBL) is an entity of B‐cell lymphoma distinct from the other molecular subtypes of diffuse large B‐cell lymphoma (DLBCL). We investigated the prevalence, specificity, and clinical relevance of mutations of XPO1, which encodes a member of the karyopherin‐β nuclear transporters, in a large cohort of PMBL. PMBL cases defined histologically or by gene expression profiling (GEP) were sequenced and the XPO1 mutational status was correlated to genetic and clinical characteristics. The XPO1 mutational status was also assessed in DLBCL, Hodgkin lymphoma (HL) and mediastinal gray‐zone lymphoma (MGZL).The biological impact of the mutation on Selective Inhibitor of Nuclear Export (SINE) compounds (KPT‐185/330) sensitivity was investigated in vitro. XPO1 mutations were present in 28/117 (24%) PMBL cases and in 5/19 (26%) HL cases but absent/rare in MGZL (0/20) or DLBCL (3/197). A higher prevalence (50%) of the recurrent codon 571 variant (p.E571K) was observed in GEP‐defined PMBL and was associated with shorter PFS. Age, International Prognostic Index and bulky mass were similar in XPO1 mutant and wild‐type cases. KPT‐185 induced a dose‐dependent decrease in cell proliferation and increased cell‐death in PMBL cell lines harboring wild type or XPO1 E571K mutant alleles. Experiments in transfected U2OS cells further confirmed that the XPO1 E571K mutation does not have a drastic impact on KPT‐330 binding. To conclude the XPO1 E571K mutation represents a genetic hallmark of the PMBL subtype and serves as a new relevant PMBL biomarker. SINE compounds appear active for both mutated and wild‐type protein. Am. J. Hematol. 91:923–930, 2016. © 2016 Wiley Periodicals, Inc. 相似文献