全文获取类型
收费全文 | 1834篇 |
免费 | 305篇 |
国内免费 | 39篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 101篇 |
妇产科学 | 21篇 |
基础医学 | 94篇 |
口腔科学 | 26篇 |
临床医学 | 303篇 |
内科学 | 591篇 |
皮肤病学 | 141篇 |
神经病学 | 179篇 |
特种医学 | 279篇 |
外科学 | 200篇 |
综合类 | 31篇 |
预防医学 | 62篇 |
眼科学 | 16篇 |
药学 | 67篇 |
中国医学 | 1篇 |
肿瘤学 | 53篇 |
出版年
2023年 | 53篇 |
2022年 | 13篇 |
2021年 | 31篇 |
2020年 | 95篇 |
2019年 | 20篇 |
2018年 | 92篇 |
2017年 | 72篇 |
2016年 | 73篇 |
2015年 | 65篇 |
2014年 | 101篇 |
2013年 | 115篇 |
2012年 | 53篇 |
2011年 | 40篇 |
2010年 | 80篇 |
2009年 | 110篇 |
2008年 | 48篇 |
2007年 | 52篇 |
2006年 | 48篇 |
2005年 | 35篇 |
2004年 | 18篇 |
2003年 | 21篇 |
2002年 | 15篇 |
2001年 | 31篇 |
2000年 | 14篇 |
1999年 | 30篇 |
1998年 | 81篇 |
1997年 | 95篇 |
1996年 | 78篇 |
1995年 | 68篇 |
1994年 | 49篇 |
1993年 | 52篇 |
1992年 | 26篇 |
1991年 | 17篇 |
1990年 | 29篇 |
1989年 | 57篇 |
1988年 | 42篇 |
1987年 | 26篇 |
1986年 | 22篇 |
1985年 | 24篇 |
1984年 | 17篇 |
1983年 | 13篇 |
1982年 | 16篇 |
1981年 | 14篇 |
1980年 | 15篇 |
1979年 | 8篇 |
1978年 | 13篇 |
1977年 | 10篇 |
1976年 | 11篇 |
1975年 | 8篇 |
1971年 | 8篇 |
排序方式: 共有2178条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
6.
7.
8.
Berman Brian MD PhD Flores Javier MD † Pariser David MD ‡ Pariser Robert MD ‡ Araujo Tami de MD Ramirez Claudia C. MD 《Dermatologic surgery》2005,31(2):135-138
BACKGROUND Dermatologic procedures often cause some degree of pain. A self-warming patch containing lidocaine and tetracaine (L/T) was developed to provide topical local anesthesia prior to painful procedures.
OBJECTIVES To evaluate the safety and efficacy of a self-warming L/T patch to provide anesthesia in adult patients undergoing minor dermatologic procedures.
METHODS An active or placebo study drug was placed on adults 30 minutes prior to minor dermatologic surgical procedures in a prospectively randomized, double-blinded manner. Subcutaneous lidocaine injection was available during the procedure as a rescue medication if requested by the subject. Immediately following the procedure, the subjects, the investigator, and an independent observer rated pain intensity and adverse events were recorded.
RESULTS Patient-reported pain intensity was significantly lower in the L/T patch group ( p < .001 ). Investigators and an independent observer rated the pain in the L/T patch group to be less than in the placebo patch group ( p = .004 and p < .001 , respectively). Forty-nine percent of patients in the placebo group required rescue subcutaneous lidocaine compared with 22% in the L/T patch study group ( p = .008 ). One patient in the L/T patch group reported a transient moderate burning sensation.
CONCLUSION The self-warming L/T patch was effective in providing clinically useful local anesthesia for minor dermatologic procedures in adult patients.
ZARS, INC., PROVIDED SUPPORT VIA A SPONSORED RESEARCH GRANT TO THE UNIVERSITY OF MIAMI. 相似文献
OBJECTIVES To evaluate the safety and efficacy of a self-warming L/T patch to provide anesthesia in adult patients undergoing minor dermatologic procedures.
METHODS An active or placebo study drug was placed on adults 30 minutes prior to minor dermatologic surgical procedures in a prospectively randomized, double-blinded manner. Subcutaneous lidocaine injection was available during the procedure as a rescue medication if requested by the subject. Immediately following the procedure, the subjects, the investigator, and an independent observer rated pain intensity and adverse events were recorded.
RESULTS Patient-reported pain intensity was significantly lower in the L/T patch group ( p < .001 ). Investigators and an independent observer rated the pain in the L/T patch group to be less than in the placebo patch group ( p = .004 and p < .001 , respectively). Forty-nine percent of patients in the placebo group required rescue subcutaneous lidocaine compared with 22% in the L/T patch study group ( p = .008 ). One patient in the L/T patch group reported a transient moderate burning sensation.
CONCLUSION The self-warming L/T patch was effective in providing clinically useful local anesthesia for minor dermatologic procedures in adult patients.
ZARS, INC., PROVIDED SUPPORT VIA A SPONSORED RESEARCH GRANT TO THE UNIVERSITY OF MIAMI. 相似文献
9.
筛检对肝癌死亡率影响的研究 总被引:5,自引:0,他引:5
5581名HBsAg阳性的男性随机分入周期性筛检组(A组,3712人)及对照组(B组,1869人)。A组(19155.4人年)共发生肝癌257例,B组(9785.5人年)为117例,两组的肝癌发生率分别为1342/10万与1196/10万;两组肝癌死亡分别为218与109例,肝癌死亡率分别为1138/10万与1114/10万。两组中Ⅰ期肝癌病例分别为29.6%与6.0%,差异有非常显著性意义。1、3、5年相对生存率A组为23.7%、7.0%、4.0%,B组为9.7%、4.0%、4.1%。用Poisson回归模型拟合显示,在调正年龄、初筛AFP及入列年份后,筛检对于肝癌的相对危险度为0.83,95%CI为0.68~1.03,有较弱的“保护”作用,Cox回归模型拟合结果显示当临床分期未引入模型时,筛检对于肝癌有显著的“保护”作用:危险率为0.6617,95%CI为0.5234~0.8365;而模型经调整后,危险率即接近“1”,95%CI为0.74~1.26。 相似文献
10.
Ralls PW; Johnson MB; Kanel G; Dobalian DM; Colletti PM; Boswell WD Jr; Radin DR; Halls JM 《Radiology》1986,161(2):451-454
FM sonography - a signal-processing technique that uses frequency and phase information as well as amplitude data - shows promise in evaluation of patients with diffuse liver disease. In a prospective blinded review of 37 patients with biopsy-proved liver disease and 42 healthy volunteers, FM sonography was clearly superior to traditional amplitude-based (AM) sonography in distinguishing healthy from diseased subjects. Statistically significant differences were seen in accuracy (FM, 98.7%; AM, 84.8%), sensitivity (FM, 97.3%; AM, 70.3%), and negative predictive value (FM, 97.7%; AM, 78.8%). Our data also suggest that current FM sonographic techniques cannot differentiate among histologic findings associated with different hepatic parenchymal abnormalities. It is unclear, therefore, whether FM imaging can reduce the numbers of patients who require biopsy for diagnosis or the frequency of biopsy procedures in patients with known disease. 相似文献