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1.
Mycoplasma pneumoniae Induces Chronic Respiratory Infection, Airway Hyperreactivity, and Pulmonary Inflammation: a Murine Model of Infection-Associated Chronic Reactive Airway Disease 总被引:9,自引:0,他引:9
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Robert D. Hardy Hasan S. Jafri Kurt Olsen Jeanine Hatfield Janie Iglehart Beverly B. Rogers Padma Patel Gail Cassell George H. McCracken Octavio Ramilo 《Infection and immunity》2002,70(2):649-654
Because chronic Mycoplasma pneumoniae respiratory infection is hypothesized to play a role in asthma, the potential of M. pneumoniae to establish chronic respiratory infection with associated pulmonary disease was investigated in a murine model. BALB/c mice were intranasally inoculated once with M. pneumoniae and examined at 109, 150, 245, 368, and 530 days postinoculation. M. pneumoniae was detected in bronchoalveolar lavage fluid by culture or PCR in 70 and 22% of mice at 109 and 530 days postinoculation, respectively. Lung histopathology was normal up to 368 days postinoculation. At 530 days, however, 78% of the mice inoculated with M. pneumoniae demonstrated abnormal histopathology characterized by peribronchial and perivascular mononuclear infiltrates. A mean histopathologic score (HPS) at 530 days of 5.1 was significantly greater (P < 0.01) than that for controls (HPS score of 0). Serum anti-M. pneumoniae immunoglobulin G was detectable in all of the mice inoculated with M. pneumoniae and was inversely correlated with HPS (r = -0.95, P = 0.01) at 530 days postinoculation. Unrestrained whole-body plethysmography measurement of enhanced pause revealed significantly elevated airway methacholine reactivity in M. pneumoniae-inoculated mice compared with that in controls at 245 days (P = 0.03) and increased airway obstruction at 530 days (P = 0.01). Murine M. pneumoniae respiratory infection can lead to chronic pulmonary disease characterized by airway hyperreactivity, airway obstruction, and histologic inflammation. 相似文献
2.
Alberto Utrero-Rico Javier Ruiz-Hornillos Cecilia González-Cuadrado Claudia Geraldine Rita Berta Almoguera Pablo Minguez Antonio Herrero-González Mario Fernández-Ruiz Octavio Carretero Juan Carlos Taracido-Fernández Rosario López-Rodriguez Marta Corton José María Aguado Luisa María Villar Carmen Ayuso-García Estela Paz-Artal Rocio Laguna-Goya 《The Journal of allergy and clinical immunology》2021,147(5):1652-1661.e1
3.
Monica Fonseca-Aten Pamela J Okada Karen L Bowlware Susana Chavez-Bueno Asuncion Mejias Ana Maria Rios Kathy Katz Kurt Olsen Simon Ng Hasan S Jafri George H McCracken Octavio Ramilo R Doug Hardy 《Annals of allergy, asthma & immunology》2006,97(4):457-463
BACKGROUND: Clarithromycin is postulated to possess immunomodulatory properties in addition to its antimicrobial activity. OBJECTIVE: To evaluate the effect of clarithromycin on serum and nasopharyngeal cytokine and chemokine concentrations in children with an acute exacerbation of recurrent wheezing. METHODS: Children with a history of recurrent wheezing or asthma and who presented with an acute exacerbation of wheezing were enrolled in a double-blind, randomized trial of clarithromycin vs placebo. Concentrations of tumor necrosis factor alpha (TNF-alpha), interferon-gamma (IFN-gamma), interleukin-1beta (IL-1beta), IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, granulocyte-macrophage colony-stimulating factor, RANTES, eotaxin, macrophage inflammatory protein 1alpha, macrophage inflammatory protein 1beta, and monocyte chemoattractant protein 1 were measured in serum and/or nasopharyngeal aspirates before, during, and after therapy. Mycoplasma pneumoniae and Chlamydophila pneumoniae infection were evaluated for by polymerase chain reaction and serologic testing. RESULTS: Nasopharyngeal concentrations of TNF-alpha, IL-1beta, and IL-10 were significantly and persistently lower in children treated with clarithromycin compared with placebo. There tended to be a greater effect of clarithromycin on nasopharyngeal cytokine concentrations in patients with evidence of M. pneumoniae or C. pneumoniae infection. No significant differences were detected in serum cytokines for children treated with clarithromycin compared with placebo. CONCLUSION: Clarithromycin therapy reduces mucosal TNF-alpha, IL-1beta, and IL-10 concentrations in children with an acute exacerbation of recurrent wheezing. 相似文献
4.
Summary Venezuelan equine encephalitis virus was passaged in KB cell cultures. The virus lost its mouse pathogenicity following subcutaneous inoculation during KB cell passage; the attenuated strain also produced smaller plaques than the pathogenic strain. Both strains grew to the same extent inAedes aegypti (L.) mosquitoes after intrathoracic inoculation. If any reversions to pathogenicity occur during development of the attenuated virus in mosquitoes, then the mutation frequency per duplication per particle must be smaller than 3.5×10–6. 相似文献
5.
Luque-Reca Octavio Soriano-Maldonado Alberto Gavilán-Carrera Blanca Acosta-Manzano Pedro Ariza-Vega Patrocinio del Paso Gustavo A. Reyes Álvarez-Gallardo Inmaculada C. Estévez-López Fernando 《Quality of life research》2022,31(7):2059-2059
Quality of Life Research - 相似文献
6.
Mariana Cárdenas-González Octavio Gaspar-Ramírez Francisco J. Pérez-Vázquez Jorge Alejandro Alegría-Torres Roberto González-Amaro Iván N. Pérez-Maldonado 《Experimental and toxicologic pathology》2013,65(5):661-665
In a recent study, our group demonstrated that when peripheral blood mononuclear cells (PBMCs) were treated “in vitro” with p,p′-DDE, a DDT metabolite, an antioxidant response and biomarkers of inflammation were induced at the mRNA level, indicating a proinflammatory state. Thus, the aim of this study was to evaluate the induction of proinflammatory molecules at the protein level in PBMCs exposed to p,p′-DDE “in vitro”. The main finding was that “in vitro” exposure to p,p′-DDE enhanced the expression of proinflammatory cytokines (TNF-α, IL-1β, IL-6) at the protein level in PBMCs. We also observed COX-2 induction at the protein level. Considering that p,p′-DDE has been identified as a persistent metabolite and is frequently found in the population, it is important to evaluate early inflammation biomarkers in populations exposed to DDT and to estimate the true risk of inflammatory disease development. 相似文献
7.
Risk of Active Tuberculosis among Index Case of Householders—A Long‐Term Assessment after the Conventional Contacts Study
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8.
K. Molloy C. Jonak F.J.S.H. Woei-A-Jin E. Guenova A.M. Busschots A. Bervoets E. Hauben R. Knobler S. Porkert C. Fassnacht R. Cowan E. Papadavid M. Beylot-Barry E. Berti S. Alberti Violetti T. Estrach R. Matin O. Akilov L. Vakeva M. Prince A. Bates M. Bayne R. Wachsmuch U. Wehkamp M. Marschalko O. Servitje D. Turner S. Weatherhead M. Wobser J.A. Sanches P. McKay D. Klemke C. Peng A. Howles J. Yoo F. Evison J. Scarisbrick 《The British journal of dermatology》2020,182(3):770-779
9.
Hiram Larangeira de Almeida Jr Gabriela Rossi Octavio Ruschel Karam Nara Moreira Rocha Ricardo Marques e Silva 《Anais brasileiros de dermatologia》2014,89(2):347-350
The purpose of this study is to compare scanning electron microscopy findings of the
blister roof in three distinct bullous diseases: one intraepidermal acantholytic
(pemphigus foliaceus); one due to hemidesmosomal dysfunction (bullous pemphigoid);
and one secondary to anchoring fibril dysfunction - type VII collagen (dystrophic
epidermolysis bullosa). In pemphigus foliaceus, acantholytic phenomena were readily
demonstrated. In bullous pemphigoid, the epidermis had a solid aspect. In dystrophic
epidermolysis bullosa a net was seen in the blister roof. 相似文献
10.
R. Fernández‐de‐Misa B. Hernández‐Machín O. Servitje F. Valentí‐Medina L. Maroñas‐Jiménez P. L. Ortiz‐Romero J. Sánchez Schmidt R. M. Pujol F. Gallardo I. Pau‐Charles M. P. García Muret S. Pérez Gala C. Román J. Cañueto L. Blanch Rius R. Izu A. Ortiz‐Brugués R. M. Martí M. Blanes M. Morillo P. Sánchez Y. Peñate J. Bastida A. Pérez Gil I. Lopez‐Lerma C. Muniesa T. Estrach 《Clinical and experimental dermatology》2018,43(2):137-143