全文获取类型
收费全文 | 1002篇 |
免费 | 115篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 56篇 |
妇产科学 | 54篇 |
基础医学 | 164篇 |
口腔科学 | 22篇 |
临床医学 | 89篇 |
内科学 | 223篇 |
皮肤病学 | 23篇 |
神经病学 | 62篇 |
特种医学 | 25篇 |
外科学 | 82篇 |
综合类 | 52篇 |
预防医学 | 123篇 |
眼科学 | 23篇 |
药学 | 67篇 |
中国医学 | 5篇 |
肿瘤学 | 43篇 |
出版年
2022年 | 7篇 |
2021年 | 16篇 |
2020年 | 13篇 |
2019年 | 16篇 |
2018年 | 20篇 |
2017年 | 25篇 |
2016年 | 17篇 |
2015年 | 26篇 |
2014年 | 37篇 |
2013年 | 52篇 |
2012年 | 65篇 |
2011年 | 67篇 |
2010年 | 36篇 |
2009年 | 26篇 |
2008年 | 65篇 |
2007年 | 43篇 |
2006年 | 43篇 |
2005年 | 47篇 |
2004年 | 55篇 |
2003年 | 38篇 |
2002年 | 47篇 |
2001年 | 22篇 |
2000年 | 23篇 |
1999年 | 25篇 |
1998年 | 10篇 |
1997年 | 8篇 |
1996年 | 11篇 |
1995年 | 8篇 |
1994年 | 13篇 |
1993年 | 14篇 |
1992年 | 11篇 |
1991年 | 11篇 |
1990年 | 10篇 |
1988年 | 7篇 |
1987年 | 8篇 |
1985年 | 8篇 |
1984年 | 9篇 |
1982年 | 7篇 |
1981年 | 6篇 |
1980年 | 7篇 |
1979年 | 9篇 |
1978年 | 6篇 |
1976年 | 8篇 |
1975年 | 7篇 |
1974年 | 7篇 |
1973年 | 8篇 |
1971年 | 10篇 |
1970年 | 6篇 |
1969年 | 6篇 |
1968年 | 8篇 |
排序方式: 共有1121条查询结果,搜索用时 15 毫秒
1.
2.
Nadir Y?net?i Nevin Oru? A Omer Ozütemiz Kamil Kumanlioglu Gül Yüce Yücel Batur 《Experimental and toxicologic pathology》2002,54(3):197-201
BACKGROUND: Many interrelationships exist between the thyroid gland and the gastrointestinal tract. Several past and recent studies have shown that the thyroid gland profoundly influences the structure and function of the exocrine pancreas in the rat. In the present study we investigated the effect of methimazole (METZ), an antithyroid drug, on cerulein induced acute pancreatitis (AP) in rats. METHODS: Rats were divided into 3 groups (10-12 weeks age, 200-250 g weight, n: 10). Group B was made hypothyroid with methimazole 5 mg/kg daily for 10 days and the others were untreated euthyroid groups. After 10 days, acute pancreatitis was induced with four doses of 20 microg/kg body weight of cerulein administered s.c at hourly intervals in group A and B while the control group C was given 4 doses of I ml saline. Pancreas wet weight (mg), plasma amylase activity (IU/l) and pancreatic histology were used as endpoints to quantify the severity of the AP. RESULTS: Plasma tri-iodothyronine (T3) (ng/dl) and thyroxine (T4) (microg/dl) levels were significantly reduced after METZ treatment for 10 days (p < 0.01). METZ pretreatment reduced significantly the cerulein induced increase in pancreatic weight (1,205 +/- 12 mg in METZ treated AP group versus 1,617 +/- 14 mg in AP group, p < 0.05) and the rise in amylase activity (7,078 +/- 816 IU/l in METZ treated AP group versus 8,611 +/- 830 IU/l in AP group p < 0.05). CONCLUSION: METZ reduces the severity of cerulein induced AP in rats. This effect might be through its antithyroid property. 相似文献
3.
4.
Effects of synthetic thyrotropin-releasing hormone (TRH) and various doses of thyroxin (T4) on prolactin (PRL)-producing cells and thyrotropic cells in the pituitary were investigated in adult male and female Rana ridibunda frogs. Animals were given 200 microg TRH once a week for 4 weeks and 0.2-0.5 mg T4 during 3 days per week for a period of 2 weeks by injections in the groin. PRL-producing cells and thyrotropic cells were identified with light microscopical and electron microscopical immunocytochemical methods, using rabbit anti-PRL and rabbit anti-thyroid stimulating hormone (TSH) as primary antibodies. TRH caused cytological changes in both cell types, which were consistent with increased synthesis and release of both PRL and TSH. Treatment with 0.5 mg T4 activated both cell types less than TRH treatment did, whereas 0.2 and 0.4 mg T4 caused inactivation of both cell types. In conclusion, mammalian TRH is effective on both types of frog pituitary cells. Our study suggests that T4 has a positive rather than a negative effect when concentrations above a certain threshold are given. 相似文献
5.
An autosomal dominant syndrome of acromegaloid facial appearance and generalised hypertrichosis terminalis. 下载免费PDF全文
A D Irvine O M Dolan D R Hadden F J Stewart E A Bingham N C Nevin 《Journal of medical genetics》1996,33(11):972-974
We report a family in which a phenotype of acromegaloid facial appearance (AFA) and generalised hypertrichosis terminalis segregates through three generations. Congenital hypertrichosis terminalis and AFA have been previously reported as independent autosomal dominant traits. This is the first report to delineate an autosomal dominant transmission of the combined phenotype. 相似文献
6.
Whole-cell recordings of EPSCs and G-protein-activated inwardly rectifying (GIRK) currents were made from cultured hippocampal neurones to determine the effect of long-term agonist treatment on the presynaptic and postsynaptic responses mediated by GABAB receptors (GABAB Rs). GABAB R-mediated presynaptic inhibition was unaffected by agonist (baclofen) treatment for up to 48 h, and was desensitized by about one-half after 96 h. In contrast, GABAB R-mediated GIRK currents were desensitized by a similar amount after only 2 h of agonist treatment. In addition, presynaptic inhibition mediated by A1 adenosine receptors (A1 Rs) was unaffected by prolonged GABAB R activation, whereas A1 R-mediated GIRK currents were desensitized. Desensitization of postsynaptic GABAB R and A1 R responses was blocked by the GABAB R antagonist (1-(S)-3,4-dichlorophenylethyl)amino-2-(S) hydroxypropyl-p-benzyl-phosphonic acid (CGP 55845A), but not by the A1 R antagonist cyclopentyldipropylxanthine (DPCPX). GIRK current amplitude could be partially restored after baclofen treatment by either coapplication of baclofen and adenosine, or intracellular infusion of the non-hydrolysable GTP analog 5'-guanylylimidodiphosphate (Gpp(NH)p). Short-term (4-24 h) baclofen treatment also significantly desensitized the inhibition of postsynaptic voltage-gated calcium channels by activation of GABAB Rs or A1 Rs. These results show that responses mediated by GABAB Rs and A1 Rs desensitize differently in presynaptic and postsynaptic compartments, and demonstrate the heterologous desensitization of postsynaptic A1R responses. 相似文献
7.
Syndrome of partial aniridia, cerebellar ataxia, and mental retardation--Gillespie syndrome 总被引:2,自引:0,他引:2
Here we describe a 5-year-old girl with Gillespie syndrome of cerebellar ataxia, partial aniridia, and mental retardation. The Gillespie syndrome probably is an autosomal recessive trait. 相似文献
8.
Marais DJ Rose RC Lane C Kay P Nevin J Denny L Soeters R Dehaeck CM Williamson AL 《Journal of medical virology》2000,60(4):403-410
The aim of the study was to determine the prevalence of antibodies to human papillomavirus (HPV) types 16, 18, 31, 33, and 45 in woman in Cape Town with cervical intraepithelial neoplasia (CIN) (n = 95), cervical cancer (n = 40), female blood donors (n = 95) and children (n = 110). The enzyme-linked immunosorbent assay (ELISA) made use of baculovirus synthesised HPV virus like particles (VLPs) as antigen. Antibodies to at least one HPV type were detected in sera from 75% of cancer patients, 71.6% of CIN patients, 44.2% of blood donors and 27.3% of children. Sera from 95 women with CIN were compared with age-matched female blood donors. There was a significant association of seropositivity to VLP-16 (P = 0.006) and VLP-45 (P = 0.008) with CIN compared with the blood donors. There was also a significant difference in the seropositivity of women with CIN to any of the five virus-like particle (VLP) types compared to the blood donors (P = 0.0002: OR = 3.2). Thirty-nine of sixty-nine (56.5%) women with CIN were found to be HPV-16 DNA positive. The average age of women in this group that were VLP-16 seropositive was 34 years and those found to be VLP-16 seronegative was 52 years of age. Antibodies to all five VLP types were detected in these populations, thus an ideal vaccine should induce protection from infection by a wide range of HPV types. 相似文献
9.
The naive Bayes model makes the often unrealistic assumption that the feature variables are mutually independent given the class variable. We interpret a violation of this assumption as an indication of the presence of latent variables, and we show how latent variables can be detected. Latent variable discovery is interesting, especially for medical applications, because it can lead to a better understanding of application domains. It can also improve classification accuracy and boost user confidence in classification models. 相似文献
10.
We report on a 5-year-old boy with moderate mental retardation, horseshoe kidneys, tricuspid valve prolapse, and a characteristic face with broad nasal root, prominent ears, and a cleft palate. These manifestations suggested the diagnosis of the Eastman-Bixler syndrome. Our patient also had an isolated growth hormone deficiency which responded successfully to treatment. 相似文献