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排序方式: 共有174条查询结果,搜索用时 46 毫秒
1.
YUSUKE HATTORI YOSHINORI HARA KENICHI MATSUURA AKIO HASEGAWA 《International journal of urology》2006,13(10):1361-1363
We report a rare case of granulomatous balanoposthitis after intravesical Bacillus-Calmette-Guerin (BCG) instillation therapy in a 58-year-old man, which followed transurethral resection (TUR) for recurrent bladder cancer, when his anterior urethra was slightly narrow and his foreskin was with phimosis. Intravesical BCG instillation therapy was started for prophylaxis of recurrent bladder cancer after TUR. Multiple painless firm papules on glans penis, edema in the foreskin and low-grade fever appeared after the seventh instillation, for which the single antituberculous agent isoniazid (300 mg/day) was administered. Biopsy of the papules on glans penis and foreskin revealed granulomatous balanoposthitis. Low-grade fever normalized and the papules disappeared within 1 week. The patient continued chemotherapy with isoniazid for the next 12 months. There was no recurrence of bladder cancer or balanoposthitis for 15 months and to date. 相似文献
2.
M. HASEGAWA 《Clinical otolaryngology》1994,19(2):135-137
Nasal resistance is affected by posture. In this study, the effects of supine and lateral recumbent positions were investigated in eight normal subjects and 31 patients with allergic rhinitis. Of the 31 patients with allergic rhinitis, five showed unilateral complete nasal obstruction and one patient showed bilateral complete obstruction during the change of posture. Total nasal resistance had a tendency to increase with repeating the change of posture (a paired t-test, P < 0.05). The supine and lateral recumbent positions did not induce variable changes in total nasal resistance in normal subjects. Posture induces complete nasal obstruction in the supine or lateral recumbent positions in some patients with allergic rhinitis. 相似文献
3.
MASAYUKI NADAI TOHRU SEKIDO IZUMI MATSUDA WANG LI KIYOYUKI KITAICHI AKIO ITOH TOSHITAKA NABESHIMA TAKAAKI HASEGAWA 《The Journal of pharmacy and pharmacology》1998,50(8):871-879
The time-dependent effects of Klebsiella pneumoniae endotoxin on hepatic cytochrome P450-dependent drug-metabolizing capacity (cytochrome P450 and b5 content, activity of aminopyrine N-demethylase, p-nitroanisole O-demethylase, aniline hydroxylase and benzphetamine N-demethylase) and on the pharmacokinetics of antipyrine have been determined in rats. Measurement of enzyme activity and antipyrine (after intravenous injection of 20 mgkg?1) were performed 2, 24 and 96 h after a single intraperitoneal injection of endotoxin (1 mgkg?1) and after repeated doses (once daily for 4 days). The contribution of tumour necrosis factor α (TNFα) to the endotoxin-induced changes was also examined in rats pretreated with granulocyte colony-stimulating factor (G-CSF). The systemic clearance of antipyrine and the activity of hepatic cytochrome P450-dependent drug-metabolizing enzymes were dramatically reduced 24 h after a single injection of endotoxin, but had returned to control levels by 96 h. The magnitudes of these decreases in these measurements after repeated doses of endotoxin were similar to those seen 24 h after the single dose. The systemic clearance of antipyrine correlated significantly with cytochrome P450 content and aminopyrine N-demethylase activity. In histopathological experiments, moderate hypertrophy of Kupffer cells was observed, with no evidence of severe liver-tissue damage. G-CSF pretreatment suppressed the increased plasma concentrations of TNFα produced 2 h after single endotoxin injection, but did not eliminate the endotoxin-induced decrease in the systemic clearance of antipyrine, suggesting that TNFα is not the sole component responsible for the reduction of cytochrome P450-mediated drug-metabolizing enzyme activity. These results provide evidence that a single intraperitoneal injection of 1·0 mgkg?1 K. pneumoniae endotoxin in rats reduces hepatic P450 and b5 levels, and reduces the activity of various cytochrome P450-mediated drug-metabolizing enzymes without causing severe liver-tissue damage. This suggests that the effect of endotoxin on hepatic cytochrome P450-mediated drug-metabolizing isozymes is non-selective. 相似文献
4.
HISATOME I.; KOTAKE H.; OGINO K.; ISHIKO R.; HASEGAWA J.; MASHIBA H.; SATO R.; OKUMURA H. 《Rheumatology (Oxford, England)》1989,28(6):525-527
We report five female cases of hypouricaemia accompanied byacute viral hepatitis (serum urate 101 ± 12 µmol/1,mean ± SD). Their urate clearance was increased to 14.2±3.4 ml/min during hyperbilirubinaemia but 24-h urateexcretion was not elevated (2.09 ± 0.64 mmol/24 h). Noother renal tubular abnormalities were detected. Comparing uratemetabolism with that of four cases of inborn renal hypouricaemia,the degree of uricosuria was lower. One patient showed elevationof serum and urinary oxypurine, which normalized with returnof a normal blood uric acid level. In all cases, the serum uratereturned to normal after improvement of liver function. We suggestthat renal uricosuria due to an isolated renal defect of uratetransport might contribute to hypouricaemia in these cases butthat inhibition of xanthine oxidase activity might also contributeto this phenomenon. KEY WORDS: Liver disease, Purine synthesisPurine synthesis, Purine synthesis, Kidney, Tubular function, Xanthine oxidase 相似文献
5.
YUKIHIRO HASEGAWA YOSHIHARU KIKAWA JUNKO MIYAMAOTO SHUJI SUGIMOTO MASANORI ADACHI TOSHIHIRO OHURA MITSUFUMI MAYUMI 《Pediatrics international》2003,45(1):5-9
BACKGROUND: In Asian countries, glycerol solution that contains fructose (5%) is often used for management of brain edema. However, glycerol and fructose may cause severe hypoglycemia and metabolic acidosis in patients with fructose-1,6-bisphosphatase (FBPase) deficiency, even under stable conditions. The aim of the present study was to determine whether glycerol solution was used for brain edema during acute metabolic decompensation of hypoglycemia and metabolic acidosis in patients with unrecognized FBPase deficiency in Japan and to examine a long-term prognosis of the patients who had this kind of severe metabolic decompensation with or without glycerol therapy. METHODS: A retrospective study of 20 children with FBPase deficiency was conducted, based on their medical records. RESULTS: Six of the 20 children were given glycerol solution for the presence or possibility of brain edema during acute metabolic decompensation of hypoglycemia and metabolic acidosis; two of the six patients administered with glycerol were given dialysis. In four patients treated with glycerol alone without dialysis, two had no brain edema before glycerol administration but it developed later after the administration. These four patients treated with glycerol alone died or developed severe neurological complications. Fourteen patients who were not treated with glycerol solution had no brain edema and showed good prognosis. CONCLUSIONS: Glycerol solution, which contains fructose in Asian countries including Japan, should not be used as an osmotic agent for treatment of brain edema in patients who have hypoglycemia and retention-type metabolic acidosis, until FBPase deficiency is ruled out by measuring blood concentration of lactate. 相似文献
6.
Takuya HASEGAWA Chiyoe MURATA Takashi NINOMIYA Tomoko TAKABAYASHI Tatsuya NODA Shinya HAYASAKA Mieko NAKAMURA Toshiyuki OJIMA 《Industrial health》2013,51(5):490-500
Problem drinking is a serious public health problem in the workplace. However, few
Japanese epidemiological studies have investigated the occupational characteristics of
problem drinking. The purpose of this study is to clarify the occupational risk factors
for problem drinking among a Japanese working population. We used data from a
random-sampling survey about mental health and suicide, conducted among Hamamatsu City
residents aged 15 to 79 yr old during May and June in 2008. The relation between
occupational factors and problem drinking was analyzed with multiple logistic regression
models stratified by gender. CAGE questionnaire was used to assess problem drinking. With
regard to employment types, problem drinkers were more prevalent among self-employed
women. With regard to occupational types, clerical and service professions had more
problem drinkers of either sex, while administrative/managerial and sales professions had
more women with such problem. With regard to company size, male problem drinkers were more
prevalent in smaller companies than in larger ones. These results indicate that the
prevalence of problem drinkers in the workplace depends on where one works. It is
necessary to consider these characteristics to provide effective measures to address
problem drinking in the workplace. 相似文献
7.
IZUMI HASHIMOTO KAZUYOSHI IMAIZUMI NAOZUMI HASHIMOTO HIROSHI FURUKAWA YUKIHIRO NODA TSUTOMU KAWABE TOYOHIRO HONDA TOMOMI OGAWA MASAKI MATSUO NAOYUKI IMAI SATORU ITO MITSUO SATO MASASHI KONDO KAORU SHIMOKATA YOSHINORI HASEGAWA 《Respirology (Carlton, Vic.)》2013,18(2):340-347
Background and objective: Bronchiolitis obliterans (BO) has been reported to develop following ingestion of Sauropus androgynus (SA), a leafy shrub distributed in Southeast Asia. Little is known about direct effects of SA on airway resident cells or haematopoietic cells in vitro. Identification of the SA component responsible for the development of BO would be an important key to elucidate its mechanism. We sought to elucidate the direct effects of SA on airway resident cells or haematopoietic cells and identify the SA element responsible for the pathogenesis of BO. Methods: SA dry powder was partitioned into fractions by solvent extraction. Human and murine monocytic cells, epithelial cells and endothelial cells were cultured with SA solution or fractions eluted from SA. We also investigated the effect of SA in vivo using a murine BO syndrome (BOS) model. Results: The aqueous fraction of SA induced significant increases of inflammatory cytokine and chemokine production from monocytic lineage cells. This fraction also induced significant apoptosis of endothelial cells and enhanced intraluminal obstructive fibrosis in allogeneic trachea allograft in the murine BOS model. We found individual differences in tumour necrosis factor α (TNF‐α) production from monocytes of healthy controls stimulated by this aqueous fraction of SA, whereas it induced high‐level TNF‐α production from monocytes of patients with SA‐induced BO. Conclusions: These results suggest that an aqueous fraction of SA may be responsible for the pathogenesis of BO. 相似文献
8.
Hiroko YAMADA Yasuhisa HASEGAWA Takashi KOSHIKAWA Tsutomu NAKASHIMA Yasushi YATABE 《Asia-Pacific Journal of Clinical Oncology》2008,4(4):233-238
Aim: Differential diagnosis, including the respective distinctions between benign and malignant tumors, follicular and papillary neoplasms, and follicular adenoma and follicular carcinoma, are always required in clinical practice, because therapeutic strategy largely depends on the diagnosis made. Methods: The present study describes a novel approach to obtaining clinically useful markers by means of the simultaneous comparison of multiple molecules using tissue array analysis. The markers examined in this study include galectin‐3, CD44v6, p53, HBME‐1, maspin and S100A4, which were reportedly useful for making these distinctions in association with metastasis and invasion. A total of 45 cases of thyroid tumors (seven adenomatous goiters, 16 follicular adenomas, 12 follicular carcinomas and 10 papillary carcinomas) were analyzed. Results: The results demonstrated the following suggestive phenotypes: galectin‐3‐, HBME‐1‐ and maspin+ as benign lesions, galection‐3‐, HBME‐1+ and maspin‐ as follicular carcinoma, and galectin‐3+, HBME‐1+ and maspin+ as papillary carcinoma. Conclusions: The expression of the molecules was assessed in each case and the expression profiles were compared. Useful multiple molecules were selected for each distinction and were correlated with each other. To understand the complex relationship, a logistic regression model was constructed. These results suggested that combined analysis of multiple molecules enhanced the differential diagnostic accuracy. 相似文献
9.
HATTORI NOBU; ARIMA MICHIO; HASEGAWA HIROSHI; SANO RYOZO; HIROTA TERUYUKI; MORII HIROYO; SAKAGUCHI ISAMU 《Japanese journal of clinical oncology》1972,2(2):139-144
A case of malignant mesenchymoma of the liver is reported. Thediagnosis was confirmed on the surgical specimen. The patientshowed marked hypercalcemia. Parathyroid hormone assay was negative. 相似文献
10.
AKIRA HASEGAWA MASAKO HATORI MASAO AMANO TOHRU IIJIMA HITOSHI ADACHI ETSUO YAMAGUCHI TAKESATORU FUKUDA KAZUHIKO MURATA RYOZO NAGAI 《Pacing and clinical electrophysiology : PACE》1997,20(2):307-312
Our objective was to determint; the adequate pacing rate during exercise in ventricular pacing by measuring exercise capacity, cardiac output, and sinus node activity. Eighteen patients with complete AV block and an implanted pacemaker underwent cardiopulmonary exercise tests under three randomized pacing rates: fixed rate pacing (VVJ) at 60 beats/min and ventricular rate-responsive pacing (VVIR) programmed to attain a heart rate of about 110 beats/min ar 130 beats/min (VVIR 110 and VVIR 130, respectively) at the end of exercise. Compared with VVI and VVIR 130, VVIR 110 was associated with an increased peak oxygen uptake(VVIR 110:20.3 ± 4.5 vs VVI: 16.9 ± 3.1; P < 0.01; and VVIR 130: 19.0 ± 4.1 mL/min per kg, respectively; P < 0.05) and a higher oxygen uptake at anaerobic threshold (15.3 ± 2.7, 12.7 ± 1.9; P < 0.01, and 14.6 ± 2.6 mL/min per kg; P < 0.05). The atrial rate during exercise expressed as a percentage of the expected maximal heart rate was lower in VVIR 110 than in VVI or VVIR 130 (VVIR 110: 75.9%± 14.6% vs VVI: 90.6%± 12.8%; P < 0.01; VVIR 110 vs VVIR 130: 89.1%± 23.1%; P < 0.05). There was no significant difference in cardiac output at peak exercise between VVIR 110 and VVIR 130. We conclude that a pacing rate for submaximal exercise of 110 beats/min may be preferable to that of 130 beats/min in respect to exercise capacity and sympathetic nerve activity. 相似文献