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V. ROLDÁN F. MARÍN J. DÍAZ P. GALLEGO E. JOVER M. ROMERA S. MANZANO‐FERNÁNDEZ T. CASAS M. VALDÉS V. VICENTE G. Y. H. LIP 《Journal of thrombosis and haemostasis》2012,10(8):1500-1507
Summary. There are limited data on the prognostic role of biomarkers in anticoagulated patients with atrial fibrillation (AF). We evaluated the prognostic value of high sensitivity TnT (hsTnT) and high‐sensitivity interleukin‐6 (hsIL6) in a large cohort of AF patients taking oral anticoagulant therapy (OAC) as both biomarkers have been associated with adverse cardiovascular events. Methods: We studied 930 patients (51% male; median age 76) with permanent/ paroxysmal AF who were stabilized (for at least 6 months) on OAC (INRs 2.0–3.0). Plasma hsTnT and hsIL6 levels were quantified by electrochemiluminescense immunoassay at baseline. Patients were followed‐up for up to 2 years, and adverse events (thrombotic and vascular events, mortality and major bleeding) were recorded. Results: At follow‐up, 96 patients (3.97%/year) died whilst 107 had an adverse cardiovascular event (3.14%/year). On multivariate analysis, high hsTnT and high hsIL6 remained significantly associated with prognosis even after adjusting for CHADS2 score: HR 2.21 (1.46–3.35, P < 0.001) for high hsTnT and 1.97 (1.29–3.02, P = 0.002) for high hsIL6, for adverse cardiovascular events. For all‐cause mortality, the HRs were 1.79 (1.13–2.83, P = 0.013) and 2.48 (1.60–3.85, P < 0.001), respectively. The integrated discrimination index (IDI) values of clinical scores (CHADS2 and CHA2DS2‐VASc) were improved by the addition of hsTnT and/or hsIL6 (all P < 0.05). Conclusion: In a large ‘real world’ cohort of anticoagulated AF patients, both hsTnT and hsIL6 levels provided prognostic information that was complementary to clinical risk scores for prediction of long‐term cardiovascular events and death, suggesting that these biomarkers may potentially be used to refine clinical risk stratification in AF. 相似文献
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BÉATRICE BREMBILLA‐PERROT M.D. ANNE M. ZINSCH M.D. JEAN M. SELLAL M.D. PIERRE Y. ZINZIUS M.D. JÉRÔME SCHWARTZ M.D. DANIEL BEURRIER M.D. CHRISTIAN DE CHILLOU M.D. JEAN P. GODENIR M.D. JEAN P. LETHOR M.D. CÉCILE MARCHAL M.D. JEAN L. CLOEZ M.D. MAHESHWAR PAURIAH M.D. RADU NOSU M.D. MARIUS ANDRONACHE M.D. FRANÇOIS MARÇON M.D. 《Pacing and clinical electrophysiology : PACE》2013,36(7):803-810
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FERNANDO CABRERA BUENO M.D. Ph.D. JAVIER ALZUETA RODRÍGUEZ M.D. Ph.D. JOSÉ OLAGÜE DE ROS M.D. IGNACIO FERNÁNDEZ‐LOZANO M.D. Ph.D. JUAN JOSÉ GARCÍA GUERRERO M.D. JOAQUÍN FERNÁNDEZ DE LA CONCHA M.D. ANTONIO HERNÁNDEZ MADRID Ph.D. JOSE MARÍA TOLOSANA VIU M.D. JOAQUÍN OSCA ASENSI M.D. ALBERTO BARRERA CORDERO M.D. Ph.D. ELENA LLORENTE HERNANGÓMEZ 《Pacing and clinical electrophysiology : PACE》2013,36(8):963-969
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ELDON E GEISERT JR. DEBORAH J BIDANSET NOBEL DEL MAR JOHN A ROBSON 《International journal of developmental neuroscience》1996,14(3):257-267
The up-regulation of the keratan sulfate proteoglycan (ABAKAN) was examined using indirect immunohistochemical methods. Previous studies indicate that the keratan sulfate proteoglycan is associated with astrocytes in the optic nerve and in the developing rat brain. In model culture systems, this proteoglycan is capable of inhibiting the growth of neurites over laminin. To determine whether the proteoglycan is up-regulated specifically during reactive gliosis, stab wounds were made in the cerebral cortex of early postnatal rats, and the up-regulation of the proteoglycan was related to the developmentally regulated gliotic response to injury. Following a stab wound in the cortex of the late postnatal rat, reactive gliosis was consistently observed along with an up-regulation of ABAKAN. When the cortex was injured on postnatal day 2, there was a variable gliotic response and considerable variation in the regulation of proteoglycan expression. Biochemical analysis revealed that ABAKAN is a large proteoglycan with multiple keratan sulfate side-chains, at least one chondroitin sulfate side-chain and at least one additional carbohydrate chain with a terminal 3-sulfoglucuronic acid. Taken together, these data demonstrate that the boundary proteoglycan ABAKAN is also associated with reactive gliosis during early postnatal development. Copyright ©1996 ISDN. Published by Elsevier Science Ltd. 相似文献
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JORGE PEDRÓN‐TORRECILLA Ph.D. MIGUEL RODRIGO M.S. ANDREU M. CLIMENT Ph.D. ALEJANDRO LIBEROS M.S. ESTHER PÉREZ‐DAVID M.D. JAVIER BERMEJO M.D. ÁNGEL ARENAL M.D. JOSÉ MILLET Ph.D. FRANCISCO FERNÁNDEZ‐AVILÉS M.D. Ph.D. OMER BERENFELD Ph.D. FELIPE ATIENZA M.D. Ph.D. MARÍA S. GUILLEM Ph.D. 《Journal of cardiovascular electrophysiology》2016,27(4):435-442