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排序方式: 共有234条查询结果,搜索用时 15 毫秒
1.
Ascoli V Scalzo CC Andreoni M Manente L Pistilli A Lo Coco F 《Virchows Archiv : an international journal of pathology》1999,435(6):612-615
We report the unusual occurrence of Kaposi’s sarcoma following asbestos-related malignant mesothelioma, in a human deficiency
virus (HIV)-negative Italian man. Seropositivity to human herpes virus 8 (HHV8) was documented at the time of mesothelioma
diagnosis and preceded the onset of Kaposi’ sarcoma with a time lapse of 13 months. HHV8 DNA was detected by polymerase chain
reaction in lesional Kaposi’s sarcoma but not within mesothelioma. By immunostaining, mesothelioma cells expressed interleukin-6
and platelet-derived growth factor, which are important for survival of Kaposi’s sarcoma cells. Besides the possibility of
a casual association, we hypothesize that mesothelioma-linked factors may have contributed to the development of Kaposi’sarcoma
in the presence of HHV8 infection.
Received: 12 April 1999 / Accepted: 24 June 1999 相似文献
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Colleoni M Boni L Calabro F Manente P Nelli P Gaion F Pancheri F Sartori F 《International journal of oncology》1995,6(6):1261-1265
The role of surgical resection remains controversial in malignant pleural mesothelioma. The assessment of its impact on prognosis is complicated by a poor understanding of the prognostic factors in the disease. We therefore evaluated, through univariate and multivariate analysis, the role on prognosis of 24 variables in 57 patients submitted to surgery from 1985 to 1993. Sixteen patients had only exploratory thoracotomy and 12 minimal residual disease after surgery (no nodules >1 cm in diameter). Thirty-four cases had epithelial histotype, 6 sarcomatous and 17 mixed. Median survival for the whole group was 15.7 months. Multivariate analysis showed a highly significant influence on survival for minimal residual disease after surgery (p=0.0006), followed by TNM stage (p=0.01). Median survival for patients with TNM stage I disease was 36.3 months and for patients with minimal residual disease 33 months. In conclusion, these data suggest that patients with limited disease have a longer survival after surgery than those with extensive disease. At the same time, our results indicate that the achievement of significant disease reduction with surgery has a critical impact on the prognosis of pleural mesothelioma. 相似文献
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Colleoni M Liessi G Mastrapasqua G Nelli P Vicario G Sgarbossa G Pancheri F Manente P 《Oncology reports》1996,3(5):879-882
Encouraging response rates and survival have been reported with intra-arterial (i.a.) chemotherapy and chemoembolization, but limited data are available on the association of the two treatment modalities. We therefore started a feasibility study of i.a. chemotherapy plus chemoembolization, performed every 28 days for 3 cycles, according to the following schedule: L-leucovorin (100 mg/m(2) i.v.), fluorouracil (800 mg/m(2) i.a.), and carboplatin (250 mg/m(2) i.a.). Chemoembolization with mitoxantrone (10 mg/m(2)) plus ethiodized oil was performed immediately after this treatment, followed by gelatin powder. Fourteen patients entered the study and were evaluable for side effects. Main patient characteristics were: males 13, females 1; median age 65 yr (range 45-75); stage TNM II-III 10, IVA 4; Childs' A 8, Childs' B 6; elevated baseline alpha-fetoprotein, 11; cirrhosis 14. No drug-related deaths have been observed. Ten patients were able to complete the program. The reasons for discontinuing treatment were worsening of liver functions in 3 cases and grade IV neutropenia in 1 patient. Eight patients had grade I-II pain and 10 patients had grade I-II fever. In conclusion the study demonstrated that chemoembolization plus i.a. chemotherapy is feasible in patients with hepatocellular carcinoma in cirrhosis and deserves further investigation. 相似文献
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David Pfister Giuseppe Storti Francesca Tancini Liborio I. Costa Massimo Morbidelli 《Macromolecular chemistry and physics.》2015,216(21):2141-2146
A new synthetic pathway for the polymerization of furan based polyesters is reported in this work. First, poly(butylene 2,5‐furandicarboxylate) cyclic oligoesters (COEs) are chemically synthesized by semi‐batch esterification. The structure of the COEs is confirmed by infrared spectroscopy, 1H, and 13C‐NMR, while the molecular weight distribution of the COEs is determined by matrix‐assisted laser desorption/ionization time of flight mass spectroscopy. The cyclic oligoesters are then successfully polymerized via ring‐opening polymerization using tetrakis(2‐ethylhexyl)‐titanate as catalyst. Differential scanning calorimetry and 1H‐NMR analysis unambiguously proves the formation of polymeric species. Both end‐group analysis from 1H‐NMR spectrum and calculation through Flory–Fox equation give comparable estimates of the number average molecular weight: 5.8 × 103 g mol?1 and 7.8 × 103 g mol?1, respectively.
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Marcello Maggio Elena Colizzi Alberto Fisichella Giorgio Valenti Graziano Ceresini Elisabetta Dall’Aglio Livia Ruffini Fulvio Lauretani Liborio Parrino Gian Paolo Ceda 《Maturitas》2013
Cognition can be deteriorated in older persons because of several potential mechanisms including the hormonal changes occurring with age. Stress events cause modification in hormonal balance with acute and chronic changes such as increase in cortisol and thyroid hormones, and simultaneous alterations in dehydroepiandrosterone sulphate, testosterone and insulin like growth factor-1 levels. The ability to cope with stress and regain previous healthy status, also called resiliency, is particularly impaired in older persons Thus, stressful conditions and hormonal dysregulation might concur to the onset of cognitive impairment in this population. 相似文献
7.
Bennardo Francesco Liborio Francesco Barone Selene Antonelli Alessandro Buffone Caterina Fortunato Leonzio Giudice Amerigo 《Clinical oral investigations》2021,25(6):3747-3755
Clinical Oral Investigations - Oral lichen planus (OLP) is a chronic immune-mediated disease that affects the oral cavity. Topical steroids are considered the treatment of choice for painful... 相似文献
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