The finding of the nematode Daniconema anguillae Moravec et Køie, 1987 (Spirurida, Dracunculoidea: Daniconematidae) in Lithuania

Summary The third-stage larvae of Daniconema anguillae Moravec et K?ie, 1987 are found in the eels fins caught from Dringis Lake (Lithuanian National park). The morphology of these larvae is briefly described.     

Naphthalimido derivatives as antifolate thymidylate synthase inhibitors

A new series of N-(substituted)benzyl-1,8-naphthalimides 4, structurally related to the previously reported thymidylate synthase (TS) inhibitor naphthaleins 3, were synthesized and compounds tested for their inhibition of several species of TS. Moreover, their in vitro cytotoxicity together with antimycotic and antibacterial properties were assayed. While no activity was detected in the antibacterial tests, the m-nitro (4ae) and the p-nitro (4af) derivatives were found able to partially inhibit TS at low micromolar concentrations. Introduction of nitro or (substituted)-amino groups in position 4 of the naphthalic ring always led to less active compounds.     

The removal of beta 2-microglobulin during continuous and intermittent hemofiltration

The kinetics of beta 2-microglobulin was studied during chronic arteriovenous filtration of the blood (altogether 8 sessions with a mean duration of 54 hrs, the rate of filtration, 0.5 kg/hr, substitution volume 12.5 kg/day) or intermittent ultrafiltration (altogether 20 sessions with a mean duration of 5.64 hrs, the rate of filtration 10 kg/hr; substitution volume, 10 kg/hr) in 8 patients with acute renal failure (ARF) and 5 ones with chronic renal failure (CRF). The authors employed filters HF-55,77,88 manufactured by "Gambro" (a polyamide membrane) and filters D-30 production by "Amicon" (a polysulfone membrane). The substitution was performed in some of ARF patients after the dilution and in some of them pre- and postdilution substitution was combined. CRF patients were parenterally substituted with balanced solution. Heparine was injected in a dose of 10-15 units per hour. The initial blood levels of beta 2microglobulin in the patients under chronic procedure were 16.6 +/- 70.7 (39.2 +/- 9.35) mg/litre, final levels 9.3 +/- 73.3 (32.5 +/- 6.36) mg/litre. The elimination volume of beta 2-microglobulin and the filtration solution was 80.5 +/- 291.2 (162.7 +/- 20.2) mg/day, comprised 1/5 of the pool and was in proportion to the amount of the substituted fluid. In the patients with intermittent filtration the initial blood levels of beta 2-microglobulin were 15-30 (25.5 +/- 1.5) mg/litre while its final levels were 5.7 +/- 26.9 (15.1 +/- 1.2) mg/litre. The elimination volume of beta 2-microglobulin and the filtration solution was 66.6 +/- 372.1 (176.1 +/- 15.8) mg per session. (ABSTRACT TRUNCATED AT 250 WORDS)     

Critical ovarian hyperstimulation syndrome in a coasted in-vitro fertilization patient

We report an instance of critical ovarian hyperstimulation syndrome in a highly responsive in-vitro fertilization patient despite the preventive measure of a 4 day 'coast' interval during which no gonadotrophins were administered while gonadotrophin-releasing hormone agonist therapy continued until serum oestradiol concentrations fell below 3000 pg/ml.