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排序方式: 共有143条查询结果,搜索用时 78 毫秒
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P. Theut Riis D.M. Saunte F. Benhadou V. del Marmol P. Guillem M. El‐Domyati H. Abdel‐Wahab C. Antoniou C. Dessinioti M.A. Gürer B. Beksaç J.C. Szepietowski L. Matusiak L. Emtestam J. Lapins H. Riad N. Doss A.F. Massa I. Hamzavi C. Nicholson M. Dolenc‐Voljc K.H. Kim J. Ohn C.C. Zouboulis I. Karagiannidis Z.B. Mokos P. Durinec G.B.E. Jemec 《Journal of the European Academy of Dermatology and Venereology》2018,32(2):307-312
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T.V. Nguyen G. Damiani L.A.V. Orenstein I. Hamzavi G.B. Jemec 《Journal of the European Academy of Dermatology and Venereology》2021,35(1):50-61
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that severely impairs patients' quality of life. It is characterized by recurrent painful nodules, abscesses and draining sinus tracts in primarily intertriginous areas. We aimed to review the most up‐to‐date information regarding the epidemiology, clinical presentation, diagnostic studies, pathogenesis, comorbidities and quality of life of patients with hidradenitis suppurativa. We performed a systematic search of Medline, Embase database (from inception to September 2019) and review of bibliographies without restrictions on year or language. HS has an estimated global prevalence of 0.00033–4.1% (but most likely 0.7–1.2% in the European‐US population). Patients still experience a significant diagnostic delay, up to several years. In the absence of pathognomonic tests, the diagnosis of HS is made from clinical observation and the disease narrative. Phenotypic variation renders diagnosis and severity assessment difficult. Ultrasound imaging is an emerging assessment tool for deep‐seated lesions. The Hurley Staging System is still widely used in severity rating. Follicular hyperkeratosis and dilatation, follicular rupture and chronic inflammation with architectural tissue changes have been implicated in the pathogenesis of HS. HS has been associated with metabolic syndrome and other risk factors for cardiovascular disease, diabetes mellitus type II, polycystic ovarian syndrome, depression, suicide and substance use disorders. It has been linked to other immune‐mediated diseases such as inflammatory bowel disease and spondyloarthropathy. Pain, pruritus, malodour, low self‐esteem, sleep and sexual dysfunctions, and poor mental health are chronic symptoms or consequences of uncontrolled disease. HS is an under‐diagnosed and under‐treated disease with a profound negative impact on patients' quality of life. In the light of its associated comorbidities, an interdisciplinary management approach may be needed to ensure the best outcomes. 相似文献
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Exploring the gaps in the evidence‐based application of narrowband UVB for the treatment of vitiligo
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Lauren M. Madigan Mohammed Al‐Jamal Iltefat Hamzavi 《Photodermatology, photoimmunology & photomedicine》2016,32(2):66-80
While narrowband ultraviolet light B (NB‐UVB) has become integral to the treatment of diffuse vitiligo, evidence‐based guidelines have been lacking with regard to dosing and administration. This is largely the result of heterogeneous study designs, ambiguous methodologies, disparate dosing strategies, and the use of varied, and somewhat arbitrary, outcome measures. In the absence of prospective trials to address each of these concerns, the available literature regarding the application of NB‐UVB for vitiligo was reviewed and the authors now pose a set of questions to the phototherapy community in an attempt to highlight gaps within our understanding. We aim to stimulate discussion, elicit expert opinion, and identify areas for future research to move toward a unified and safe treatment guideline for patients afflicted by this disease. 相似文献
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The role of age in pediatric cochlear implantation 总被引:6,自引:0,他引:6
Baumgartner WD Pok SM Egelierler B Franz P Gstoettner W Hamzavi J 《International journal of pediatric otorhinolaryngology》2002,62(3):223-228
OBJECTIVE: To document progress, benefit and importance of age in paediatric cochlear implantation. DESIGN: The EARS (Evaluation of Auditory Responses to Speech) test battery was performed on 33 prelingually deaf children at regular intervals up to 36 months following implantation. All children participated in individually tailored intensive audiological rehabilitation programs after receiving their implants. In this respect, it was attempted to evaluate speech perception scores in children implanted before and after the age of 3 in a homogenous group. RESULTS: All children demonstrated encouraging improvements over time in their speech recognition abilities. Furthermore, it was observed that the children who were implanted under the age of 3 achieved higher levels of speech perception performance. CONCLUSION: In order to shorten the process of central maturation of the auditory system, it is desirable to implant the children as young as possible. Early intervention seems to be the ideal strategy in enabling prelingually deaf children to derive maximum benefit from cochlear implantation. 相似文献
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Audiological performance with cochlear reimplantation from analogue single-channel implants to digital multi-channel devices. 总被引:3,自引:0,他引:3
J S Hamzavi W D Baumgartner O Adunka P Franz W Gstoettner 《Audiology : official organ of the International Society of Audiology》2000,39(6):305-310
Cochlear implantation has been performed for almost two decades at the Vienna University Hospital. Until 1994, single-channel implants were used (Ball-Electrode, SC6/2SC6, Vienna/Epoxy, Med-E1, Innsbruck, Austria). The development of multi-channel devices (Combi 40/40+), which provide significantly improved speech recognition performance, led to the reimplantation of some patients who had previously received single-channel implants. It was of particular interest to find out if there was a deterioration of the central "learning process" by the reimplantation from the analogue single-channel device to the tonotopic pulsatile multi-channel stimulation. In this study, we attempted to demonstrate that single-channel implants have an impact on the neural organisation of the auditory system. Two groups of post-lingually deaf adult patients were tested. Group A had previously received single-channel implants and were reimplanted with the new Combi 40/40+ cochlear implant (Med-E1, Innsbruck, Austria) in the same ear. Group B was implanted only with the Combi 40/40+. Six different speech recognition tests were subsequently performed on all patients, and the two groups performed similarly. Furthermore, it was discovered that group A obtained significant speech recognition improvement (p<0.05) with monosyllabic words and number tests 1 month following reimplantation. 相似文献
9.
Optic neuritis is the most common cause of decreased vision due to optic nerve dysfunction in patients who are 20 to 40 years of age. Optic neuritis, or inflammation of the optic nerve, is primarily due to idiopathic demyelination. Demyelinative lesions seen in optic neuritis are not unlike those seen in plaque associated with multiple sclerosis. In fact, acute inflammatory demyelination of the optic nerve commonly occurs as an initial manifestation of multiple sclerosis. Key features of optic neuritis include a vision loss occurring over 1 to 10 days, color vision impairment, eye pain with motility, and an afferent pupillary defect. This significant diagnosis can be challenging to an emergency physician as it is relatively infrequently observed. 相似文献
10.
The aim of the study was to evaluate the speech discrimination ability of postlingually deaf adults implanted with the Combi 40 cochlear implant in noise and to compare the results with the speech discrimination ability of patients provided with hearing aids. The 12-month postoperative hearing performance of 12 consecutive patients was tested using a sentence discrimination test in quiet and noise. The results of the present study demonstrate that all patients obtained substantial benefit from their implants even in situations coupled with noise. The speech understanding of cochlea-implanted patients appears to be better than that of patients provided with hearing aids. Very high scores (mean, 40.2%) were achieved at a signal-noise ratio of 15 dB. 相似文献