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1.
Cutaneous histoplasmosis with prominent parasitization of epidermal keratinocytes: report of a case
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Hedieh H. Honarpisheh Jonathan L. Curry Kristen Richards Priyadharsini Nagarajan Phyu P. Aung Carlos A. Torres‐Cabala Doina Ivan Carol R. Drucker Richard Cartun Victor G. Prieto Michael T. Tetzlaff 《Journal of cutaneous pathology》2016,43(12):1155-1160
Disseminated histoplasmosis most commonly occurs in immunosuppressed individuals and involves the skin in approximately 6% of patients. Cutaneous histoplasmosis with an intraepithelial‐predominant distribution has not been described. A 47‐year‐old man was admitted to our institution with fever and vancomycin‐resistant enterococcal bacteremia. He had been diagnosed with T‐cell prolymphocytic leukemia 4 years earlier and had undergone matched‐unrelated‐donor stem cell transplant 2 years earlier; on admission, he had relapsed disease. His medical history was significant for disseminated histoplasmosis 6 months before admission, controlled with multiple antifungal regimens. During this final hospitalization, the patient developed multiple 2–5 mm erythematous papules, a hemorrhagic crust across the chest, shoulders, forearms, dorsal aspect of the fingers, abdomen and thighs. Skin biopsy revealed clusters of oval yeast forms mostly confined to the cytoplasm of keratinocytes and within the stratum corneum; scattered organisms were present in the underlying superficial dermis without any significant associated inflammatory infiltrate. Special stains and immunohistochemical studies confirmed these to be Histoplasma organisms. We highlight this previously unrecognized pattern of cutaneous histoplasmosis to ensure its prompt recognition and appropriate antifungal therapy. 相似文献
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Synthesis,evaluation, and molecular docking studies of aryl urea‐triazole‐based derivatives as anti‐urease agents
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Setareh Moghimi Fereshteh Goli‐Garmroodi Maryam Allahyari‐Devin Hedieh Pilali Malihe Hassanzadeh Shabnam Mahernia Mohammad Mahdavi Loghman Firoozpour Massoud Amanlou Alireza Foroumadi 《Archiv der Pharmazie》2018,351(7)
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Preoperative staging of gastric adenocarcinoma: comparison of helical CT and endoscopic US 总被引:46,自引:0,他引:46
Habermann CR Weiss F Riecken R Honarpisheh H Bohnacker S Staedtler C Dieckmann C Schoder V Adam G 《Radiology》2004,230(2):465-471
PURPOSE: To compare the performance of helical computed tomography (CT) and endoscopic ultrasonography (US) in the preoperative staging of gastric cancer. MATERIALS AND METHODS: Fifty-one consecutive patients with a primary malignant gastric tumor (stage T2-T4) were preoperatively evaluated with both helical CT and endoscopic US within 3 days. Each tumor was staged according to the TNM classification system with both modalities. All patients subsequently underwent surgery. Results of CT and endoscopic US were compared with histologic staging of tumor invasion depth and regional lymph node metastasis. For comparison of CT and endoscopic US data, the marginal homogeneity test was used, and a P value of less than.05 was determined to indicate statistical significance. RESULTS: In comparison with histologic results, CT achieved correct T staging in 39 patients (76%) and correct N staging in 35 patients (70%). The corresponding results for endoscopic US achieved correct T staging in 44 patients (86%) and correct N staging in 45 patients (90%). There was no significant difference between T staging (P =.55) and N staging (P >.99). Because of challenging detection of wall layers, correct T staging was difficult for CT and endoscopic US in the differentiation of T2 and T3 lesions. CONCLUSION: Compared with endoscopic US, helical CT focused on the stomach provides valuable results regarding T and N staging in patients with gastric cancer. 相似文献
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Effect of time of preparation on pentagastrin-induced symptom, endocrine and cardiovascular responses 总被引:1,自引:0,他引:1
Pentagastrin is a cholecystokinin (CCK)-B agonist and laboratory panicogenic agent that produces endocrine (ACTH and cortisol), symptom (anxiety, panic) and cardiovascular (heart rate) responses. Although in vitro data have supported its chemical stability, preliminary data suggested that increasing time between drug preparation and drug infusion could reduce the magnitude of endocrine and symptom responses. The current study examined this possibility. Twenty-one healthy subjects presented at the University of Michigan General Clinical Research Center (GCRC) and had an intravenous catheter inserted. Heart rate, cortisol levels and subjective anxiety were measured before and after pentagastrin and placebo injections. Pentagastrin was prepared either within 60 min of IV infusion (Normal Preparation group) or at least 3.5 h prior to infusion (Early Preparation group). Relative to the Normal Preparation group, Early Preparation subjects had similar heart rate responses but significantly smaller cortisol and subjective anxiety responses. Early preparation of pentagastrin thus appears to weaken endocrine and subjective anxiety responses, highlighting the importance of attending to often overlooked procedural variables (e.g., time between preparation and administration) in studies of this type. The sensitivity of cortisol and anxiety responses to preparation time, but insensitivity of heart rate, is consistent with previous studies suggesting different thresholds of activation for the three response modalities. These differential sensitivities may suggest different and separable CCK-B stimulated pathways for each response, which combine to produce panic, rather than a single, unified CCK-B mediated panicogenic response. 相似文献
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Sara Saffar Soflaei MD PhD Mahmoud Ebrahimi MD Hamid Reza Rahimi MD PhD AmirAli Moodi Ghalibaf MD Maryam Jafari MD Hedieh Alimi MD Nasrin Talkhi MSc Bahram Shahri MD Alireza Heidari-Bakavoli MD Fatemeh Malakouti Mahla Velayati Reza Assaran-Darban PhD Malihehsadat Abedsaeidi MSc Farnoosh Azarian MSc MohammadReza Latifi MSc Mohammad Reza Mohammad Taghizadeh Sarabi MSc Gordon A. Ferns MD PhD Habibollah Esmaily PhD Mohsen Moohebati MD Majid Ghayour-Mobarhan MD PhD 《Annals of noninvasive electrocardiology》2023,28(6):e13086
Background
Twelve-lead electrocardiogram (ECG) is a common and inexpensive tool for the diagnostic workup of patients with suspected cardiovascular disease, both in clinical and epidemiological settings. The present study was designed to evaluate ECG abnormalities in Mashhad population.Methods
ECGs were taken as part of MASHAD cohort study (phase1) and were coded according to the Minnesota coding criteria. Data were analyzed using SPSS.Results
Total 9035 ECGs were available for final analysis including 3615 (40.0%) male and 5420 (60.0%) female. Among ECG abnormalities precordial Q wave, major T-wave abnormalities, inferior Q wave, sinus bradycardia, and left axis deviation were the most prevalent abnormalities. The frequency of precordial and inferior Q wave, inferior QS pattern, major and minor ST abnormalities, major and minor T abnormalities, Wolff-Parkinson-White and Brugada pattern, sinus bradycardia, sinus tachycardia, left axis deviation, ST elevation, and tall T wave were significantly different between two genders. Moreover, the frequency of Q wave in precordial and aVL leads, QS pattern in precordial and inferior leads, major and minor T-wave abnormalities, Wolff-Parkinson-White, atrial fibrillation, sinus bradycardia, left axis deviation, and ST elevation were significantly different in different age groups. A comparison of the heart rate, P-wave duration, and QRS duration between men and women indicated that there was a significant difference.Conclusions
Our finding indicated that the prevalence ECG abnormalities are different between men and women and also it varied in different age groups. 相似文献8.
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Minouchehr S Radtke A Sotiropoulos GC Molmenti EP Braun F Hindennach M Honarpisheh H Cicinnati VR Malagó M Broering DC Schroeder T 《Hepato-gastroenterology》2011,58(110-111):1664-1669