全文获取类型
收费全文 | 1662篇 |
免费 | 123篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 70篇 |
妇产科学 | 30篇 |
基础医学 | 217篇 |
口腔科学 | 68篇 |
临床医学 | 136篇 |
内科学 | 440篇 |
皮肤病学 | 67篇 |
神经病学 | 104篇 |
特种医学 | 117篇 |
外科学 | 186篇 |
综合类 | 18篇 |
一般理论 | 1篇 |
预防医学 | 114篇 |
眼科学 | 9篇 |
药学 | 85篇 |
中国医学 | 3篇 |
肿瘤学 | 122篇 |
出版年
2023年 | 10篇 |
2022年 | 10篇 |
2021年 | 26篇 |
2020年 | 20篇 |
2019年 | 42篇 |
2018年 | 45篇 |
2017年 | 30篇 |
2016年 | 30篇 |
2015年 | 53篇 |
2014年 | 56篇 |
2013年 | 95篇 |
2012年 | 81篇 |
2011年 | 80篇 |
2010年 | 77篇 |
2009年 | 69篇 |
2008年 | 68篇 |
2007年 | 87篇 |
2006年 | 69篇 |
2005年 | 72篇 |
2004年 | 73篇 |
2003年 | 64篇 |
2002年 | 58篇 |
2001年 | 39篇 |
2000年 | 46篇 |
1999年 | 38篇 |
1998年 | 40篇 |
1997年 | 40篇 |
1996年 | 33篇 |
1995年 | 28篇 |
1994年 | 28篇 |
1993年 | 24篇 |
1992年 | 15篇 |
1991年 | 17篇 |
1990年 | 13篇 |
1989年 | 21篇 |
1988年 | 27篇 |
1987年 | 21篇 |
1986年 | 21篇 |
1985年 | 18篇 |
1984年 | 19篇 |
1983年 | 12篇 |
1982年 | 18篇 |
1981年 | 8篇 |
1980年 | 7篇 |
1979年 | 11篇 |
1978年 | 9篇 |
1977年 | 5篇 |
1976年 | 5篇 |
1975年 | 12篇 |
1974年 | 4篇 |
排序方式: 共有1805条查询结果,搜索用时 15 毫秒
1.
2.
Carlos Ferrer Albiach Antonio Conde Moreno Marta Rodríguez Cordón Virginia Morillo Macías Ana Bouché Babiloni Inmaculada Beato Tortajada Ángel Sánchez Iglesias Alicia Francés Muñoz 《Clinical & translational oncology》2010,12(1):22-26
Hypoxia is related to poor prognosis because it is associated to chemo-and radioresistance. During recent years the evolution
of imaging methods like PET/CT and MRI has meant the appearance of new perspectives with direct implications in radiation
therapy. We discuss previous experiences in staging, planning and in the follow-up process with these techniques for measuring
tumour hypoxia. 相似文献
3.
The relationship between bladder cancer and occupational exposure to asbestos was investigated between 1978 and 1982 at La Paz Hospital in Madrid in a case-control study conducted among 353 male patients and 53 women with a diagnosis of urothelium carcinoma, and among an equal number of controls matched in age (decade of life), sex and date of admission to the hospital. The results showed that bladder cancer is associated with occupational exposure to asbestos. 相似文献
4.
5.
M Fofana S Toure M Dadhi Balde O Damby Balde T Sow A Toure A Conde 《Annales de cardiologie et d'angeiologie》1988,37(8):413-417
Over a period of two years (1986-1987), the authors have studied the morbidity and mortality of various cardiovascular diseases in a hospital population of 268 patients. By comparing it with a previous similar study conducted over 5 years (1981-1985), they have reached the following conclusions: the prevalence of the main nosological groups is equivalent (H.B.P., rheumatoid valvulopathies, chronic pulmonary heart, ischemic cardiopathies; severity of the valvulopathies and their prognosis which raise social and medical problems especially that of cardiac surgery, still inexistent in Guinea; increased prevalence of diseases such as hypertension and rheumatoid valvulopathies. They suggest early screening, especially for rheumatoid valvulopathies and hypertension, which cause major social problems because of their complications. Besides, it would be desirable that visits at regular intervals be made mandatory in schools and universities and at preemployment examinations and in all SMI (?) centers in the country. 相似文献
6.
7.
G Diéguez A L García M V Conde B Gómez L Santamaría S Lluch 《Microvascular research》1987,33(2):143-154
The carotid rete of Artiodactyla, an intracranial arterial plexus which supplies blood to the brain, has intrigued investigators for a long time. This study was designed to examine the responsiveness of isolated retial arteries (250-700 microns in external diameter) of goat, pig, and cattle. The findings in these arteries were compared to those observed in cerebral arteries (250-650 microns in external diameter) of the same animal species. The magnitude of the arterial responses to potassium chloride varied with the resting tension applied to the tissue. The two types of vessels exhibited similar resting tension values (0.3 g) for maximal tension development in response to potassium chloride; however, the ability of retial vessels to contract in the presence of potassium chloride was consistently smaller than that of cerebral arteries. The contractile response of retial arteries to norepinephrine (10(-9) to 10(-4) M), tyramine (10(-8) to 10(-3) M), and field electrical stimulation (2-16 Hz) was negligible. The same retial arteries exhibited dose-dependent contractions in response to 5-hydroxytryptamine (10(-9) to 10(-5) M) and histamine (10(-9) to 3 X 10(-4) M). Cerebral arteries exhibited larger responses to the vasoactive agents than retial arteries. Our findings indicate that retial arteries have a small vasomotor activity in response to adrenergic stimulation or to vasoactive agents. Therefore, the carotid rete of Artiodactyla may have a low ability to change resistance to blood flow under neural or hormonal influences. 相似文献
8.
Lymph node metastases: safety and effectiveness of MR imaging with ultrasmall superparamagnetic iron oxide particles--initial clinical experience 总被引:14,自引:0,他引:14
9.
10.
Treatment with anti-LFA-1 alpha monoclonal antibody selectively interferes with the maturation of CD4- 8+ thymocytes.
下载免费PDF全文
![点击此处可从《Immunology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Maturation of T lymphocytes in the thymus is driven by signals provided by soluble factors and by the direct interaction between thymocytes and stromal cells. Although the interaction between T-cell receptor (TCR) and major histocompalibility complex (MHC) molecules on stromal cells is crucial for T-cell development, other accessory molecules seem to play a role in this process. In order to better understand the role of lymphocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1) molecules in thymocyte maturation, mice were treated from birth with saturating doses of non-cytolytic-specific monoclonal antibodies. The effect of this treatment on thymocyte subpopulations and the expression of CD3 and TCR-alpha beta by these cells was investigated by flow cytometry. Our data demonstrated that the effective saturation of LFA-1 alpha chain in the thymus, but not ICAM-I or LFA-I beta chain, selectively interfered with the maturation of CD8+ T cells, as manifested by a marked reduction in the frequency of CD4-8+ thymocytes expressing high levels of CD3 and TCR-alpha beta. This selective reduction was also observed in peripheral blood mononuclear cells and spleen cells. The analysis of the frequencies of various V beta TCR showed that CD4-8+ thymocytes were globally affected by the treatment. These results underline the importance of the interaction between LFA-1 and its ligands in the maturation of CD8+ T cells and document the existence of different molecular requirements for the differentiation of CD4+ and CD8+ T cells. 相似文献