全文获取类型
收费全文 | 420篇 |
免费 | 9篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 17篇 |
儿科学 | 22篇 |
妇产科学 | 2篇 |
基础医学 | 25篇 |
口腔科学 | 9篇 |
临床医学 | 38篇 |
内科学 | 50篇 |
皮肤病学 | 8篇 |
神经病学 | 17篇 |
特种医学 | 81篇 |
外科学 | 11篇 |
综合类 | 30篇 |
预防医学 | 83篇 |
眼科学 | 5篇 |
药学 | 14篇 |
中国医学 | 1篇 |
肿瘤学 | 23篇 |
出版年
2020年 | 2篇 |
2019年 | 3篇 |
2018年 | 3篇 |
2016年 | 3篇 |
2015年 | 7篇 |
2014年 | 9篇 |
2013年 | 14篇 |
2012年 | 14篇 |
2011年 | 10篇 |
2010年 | 14篇 |
2009年 | 9篇 |
2008年 | 8篇 |
2007年 | 16篇 |
2006年 | 15篇 |
2005年 | 14篇 |
2004年 | 13篇 |
2003年 | 15篇 |
2002年 | 16篇 |
2001年 | 12篇 |
2000年 | 10篇 |
1999年 | 9篇 |
1998年 | 25篇 |
1997年 | 29篇 |
1996年 | 17篇 |
1995年 | 14篇 |
1994年 | 19篇 |
1993年 | 9篇 |
1992年 | 7篇 |
1991年 | 3篇 |
1990年 | 8篇 |
1989年 | 14篇 |
1988年 | 12篇 |
1987年 | 4篇 |
1986年 | 9篇 |
1985年 | 4篇 |
1984年 | 2篇 |
1981年 | 6篇 |
1979年 | 2篇 |
1977年 | 4篇 |
1975年 | 2篇 |
1969年 | 5篇 |
1967年 | 3篇 |
1960年 | 1篇 |
1958年 | 1篇 |
1956年 | 1篇 |
1955年 | 1篇 |
1930年 | 1篇 |
1924年 | 1篇 |
1923年 | 1篇 |
1910年 | 1篇 |
排序方式: 共有436条查询结果,搜索用时 187 毫秒
1.
Arthrograms of the temporomandibular joint were obtained in 20 symptomatic joints that had previous reconstructive arthroplasty with disk repositioning because of internal derangements. Preoperative arthrograms were available for comparison in 18 joints. Symptoms resulting in a postoperative arthrogram included pain, limited ability to open the mouth, and clicking of the joints. Postoperative arthrographic findings included limited anterior translation of the condyle (90%), irregularity in outline of the intraarticular contrast agent (60%), a conical configuration of the posterior recess (25%), decreased size of the joint (28%), anterior displacement of the meniscus (25%), and perforated meniscus (15%). Many of these findings may have resulted from fibrosis and scarring, which may be a response to intraarticular bleeding. The mechanism by which the fibrosis causes the postsurgical arthrographic features is discussed. 相似文献
2.
In mammals, the indolealkylamine melatonin is synthesized mainly in the pineal gland and to a lesser degree in a number of extrapineal sites. To obtain more information on its distribution, melatonin was measured in the membranous cochlea of the guinea pig. Moreover, melatonin and other serotonin derivatives were determined in organ cultures after incubation with 14C-labelled serotonin. The results show that melatonin is detectable in the organ of Corti and the basilar membrane, and to a lesser degree also in the cochlear nerve and stria vascularis, including the spiral ligament. In vitro studies reveal the occurrence of a number of radiolabelled serotonin derivatives indicating that two of the melatonin-forming enzymes, serotonin N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT) are present in membranous cochlea. It is concluded that melatonin is synthesized in the guinea pig cochlea. Its role as modulator of hair cell function is dissolved. 相似文献
3.
4.
Han JY; Kim HK; Choi BG; Moon H; Hong YS; Lee KS 《Japanese journal of clinical oncology》1998,28(12):749-753
BACKGROUND: Quality of life (QOL) assessment has emerged to measure and
quantify the balance between treatment benefit and toxicity, and has a
value in predicting response and overall survival in cancer patients.
METHODS: From July 1995 to February 1997, 38 symptomatic patients with
advanced non-small cell lung cancer (NSCLC) were treated with MIP
chemotherapy (mitomycin 6 mg/m2, ifosfamide 3000 mg/m2 and cisplatin 50
mg/m2 on day 1 every 3 weeks). Patients were assessed for QOL including
physical well-being, general symptoms and lung cancer-specific symptoms, as
well as objective response. RESULTS: The overall response rate was 38.9%
(14/36, all were partial response) and the median duration of response was
3.5 months [95% confidence interval (CI) 2.0-4.0]. The median duration of
overall survival was 7 months (95% CI 5.9-8.5). The overall improvement of
QOL was 58.3% with 21 patients feeling better on treatment. The toxicity of
chemotherapy was mild, mainly nausea/vomiting and minimal alopecia. Using
multiple clinical predictors of survival (age, histology, stage,
performance status), only change of QOL emerged significantly (P = 0.0007).
CONCLUSIONS: MIP had an endurable response and low toxicity profile, and
provided good QOL. Integral QOL data in our study provided the strong
prediction of survival in advanced NSCLC. Further experienced QOL study
will provide greatly enhanced outcome data in clinical trials.
相似文献
5.
6.
7.
The combination of high-dose busulfan (16 mg/kg) and 200 mg/kg cyclophosphamide is gaining increasing significance as a preparative regimen prior to autologous, syngeneic, or allogeneic marrow transplantation. A new regimen of high-dose busulfan in conjunction with a reduced dose of 120 mg/kg cyclophosphamide has recently been described as a preparative regimen prior to allogeneic transplantation. To determine the drug-related nonhematologic toxic effects of this new regimen without confounding factors associated with allogeneic transplantation, we conducted a pilot study using this new regimen in 20 patients with acute myeloid leukemia (AML) in first remission prior to autologous unpurged marrow transplantation. All patients experienced transient non-life-threatening acute drug-related toxicity with skin reactions in 20 (100%), nausea and vomiting in 20 (100%), oral mucositis in 18 (90%), hepatic functional impairment in 17 (85%), hemorrhagic cystitis in three (15%), and generalized seizures in two (10%) of these patients, respectively. Two procedural, fatal complications resulted from infectious causes that were not directly related to the speed of hematopoietic reconstitution or the toxicity of the preparative regimen. The 3-year event-free survival estimate (55% +/- 11%) and probability of leukemic recurrence (38% +/- 11%) attained with this new regimen in recipients of autografts in first remission of AML are promising and challenge comparisons with preparative regimens employing combinations of cytotoxic agents or total body irradiation (TBI). 相似文献
8.
9.
Hypovitaminosis D (<30 ng/ml) is highly prevalent in allogeneic hematopoietic cell transplantation (alloHCT), but the relevance
of influencing factors for serum 25-hydroxyvitamin D3 [25(OH)D3] status in adult patients remains unknown. We are the first to have prospectively assessed 25(OH)D3 status and its influencing factors in 102 patients before and at days +30 and +100 after alloHCT. Among others, we evaluated
age, gender, weight, fat mass, season, sun exposure habits, and dietary and supplemental vitamin D intake as factors potentially
influencing baseline vitamin D status in uni- and multivariate linear regression analysis. Furthermore, we investigated the
impact of changes in fat mass, duration of parenteral nutrition, and acute graft-versus-host disease (aGVHD) on the course
of serum 25(OH)D3. Baseline 25(OH)D3 concentrations were 16.4 ± 8.9 ng/ml, revealing that the majority (89%) had concentrations beneath the normal range. In multivariate
linear regression model, only higher body fat mass remained an independent risk factor for reduced baseline 25(OH)D3 concentrations (P = 0.007). In the early post-transplant period, 25(OH)D3 status remained low, revealing a tendency to further deterioration, especially in patients with corticosteroid-treated aGVHD
(≥II). Reduced vitamin D status was very common in these patients before and after alloHCT, whereby the most important influencing
factors, namely season and dietary factors seem to have little impact. Our findings suggest that monitoring and if necessary,
correcting vitamin D status may be indicated at regular intervals before alloHCT and during long-term follow-up. Further investigations
of these patients' vitamin D requirements are needed, especially if they are on long-term corticosteroids. 相似文献
10.
Baumgartner C; Morell A; Hirt A; Bucher U; Forster HK; Doran JE; Matter L; Brun del Re G; Wagner HP 《Blood》1988,71(5):1211-1217
Elimination of neoplastic B cell populations from autologous bone marrow grafts also removes normal B lymphocytes. This is potentially hazardous for the reconstitution of the immune system in patients undergoing high-dose chemotherapy and total body irradiation followed by autologous marrow rescue. Five pediatric patients with B cell non- Hodgkin's lymphoma in first remission undergoing such a regimen were studied. They received bone marrow pretreated with anti-Y 29/55 monoclonal antibody and complement. B and T lymphocyte subpopulations reached normal levels within 6 months after autologous bone marrow transplantation (ABMT), and serum immunoglobulin levels became normal within 4 to 9 months. Vaccination with diphtheria and tetanus toxoid, trivalent poliomyelitis vaccine of the Salk type, and pneumococcal capsular antigens (38 to 54 months after transplantation) gave rise to specific antibody production. ABO isoagglutinins could be demonstrated in all patients. The response pattern was similar to that of patients who received unmanipulated autologous bone marrow. It is concluded that ex vivo anti-Y 29/55 depletion of the marrow graft does not induce relevant disturbances of humoral immune functions. 相似文献