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Surjit Singh Saurabh Singh Abisha Thangaswamy Pugazhenthan Thangaraju Shoban Babu Varthya 《Dermatologic therapy》2021,34(1):e14487
Monoclonal antibodies are explored for their therapeutic potential in Psoriasis. To evaluate Risankizumab in the moderate to severe psoriasis with regard to efficacy, tolerability, and safety PubMed, Cochrane Central Register of Controlled Trials (CENTRAL) and clinicaltrials.gov , databases were searched for relevant RCTs. The reference lists of relevant publications were also scanned manually to identify any further studies not indexed in the searched databases. Only RCT aiming to evaluate the role of Risankizumab in the treatment of moderate to severe psoriasis were considered eligible for this systematic review. Intervention group was patients taking Risankizumab and placebo or other monoclonal antibody was considered as control group. Cochrane review manager 5 (RevMan) version 5.3 was used for data synthesis and meta‐analysis. Quality assessment of included randomized controlled trials was done with Cochrane Collaboration risk of bias assessment tool, version 2.0 (ROB‐2). Overall Grading of evidence for study objectives was performed with GRADE Pro GDT software. A total of seven studies were included in analysis with total of 1533 and 710 patients in Risankizumab and standard care groups, respectively. Statistically significant increase in percentage of individual achieving PASI90 (OR = 11.01 (95% CI = 8.67‐13.99), DLQI‐01 (OR = 6.95 (95% CI = 5.53‐8.75), sPGA‐01 (OR = 14.22 (95% CI = 11.10‐18.22); sPGA‐0 (OR = 6.39 (95% CI = 4.79‐8.54) in risankizumab group as compared with control, with high quality of evidence. Increased risk of infections with risankizumab as compared with placebo (OR = 1.44 [95% CI = 1.13‐1.83], high quality evidence), while no difference in SAE among two groups. Analysis of all outcome data from RCTs. In the light of evidence from systematic review on effectiveness of Risankizumab, we propose treatment with risankizumab for psoriasis patients not responding to available treatment. 相似文献
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A questionnaire was used to gather information on the wild leafy vegetables consumed. The phenolic concentrations were determined by the vanillin, butanol, and tannin binding assays. Seventy-nine traditional vegetables were mentioned by the respondents and 20 of these were classified according to their species. The contents of flavonoids varied from 1.2 mg/g for Cleome gynandra to 8.0 mg/g for Bidens pilosa. The levels of proanthocyanidins ranged from 1.9 mg/g for lettuce to 11.2 mg/g for Bidens pilosa. The tannin contents of the vegetables ranged from 5.7 mg/g for Cleome gynandra to 8.3 mg/g for Bidens pilosa. The present study showed that these vegetables are valuable sources of phenolic compounds as compared to some exotic species. 相似文献
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Thangaswamy CR 《Anesthesia and analgesia》2008,107(3):1083-4; author reply 1084
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Cristina C. Clement Padma P. Nanaware Takahiro Yamazaki Maria Pia Negroni Karthik Ramesh Kateryna Morozova Sangeetha Thangaswamy Austin Graves Hei Jung Kim Tsai Wanxia Li Marco Vigano’ Rajesh K. Soni Massimo Gadina Harley Y. Tse Lorenzo Galluzzi Paul A. Roche Lisa K. Denzin Lawrence J. Stern Laura Santambrogio 《Immunity》2021,54(4):721-736.e10
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Banstola Amrit Simkhada Padam van Teijlingen Edwin Bhatta Surya Lama Susma Adhikari Abisha Banstola Ashik 《Maternal and child health journal》2020,24(6):806-816
Maternal and Child Health Journal - The purpose of this health system’s study is to assess the availability of Emergency Obstetric Care (EmOC) services in birthing centres in Taplejung... 相似文献