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目的探讨血管细胞黏附分子-1(VCAM-1)在玫瑰糠疹中的发病机制。方法采用免疫组化SP法检测玫瑰糠疹皮损血管内皮细胞VCAM-1的表达。结果皮损组血管内皮细胞VCAM-1的表达均高于正常皮肤组及玫瑰糠疹皮损周围正常皮肤组,玫瑰糠疹皮损周围正常皮肤组的表达高于正常皮肤组,差异均有显著性(P<0.05)。结论VCAM-1在玫瑰糠疹皮损血管内皮细胞上的高表达与真皮浅层血管周围淋巴细胞浸润有关,参与了玫瑰糠疹的炎症反应。 相似文献
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患者女,25岁,未婚,因外阴、肛门肿物4年伴疼痛于2000年5月8日收入院。患者于4年前外阴及肛门瘙痒,并出现米粒大小的刺状赘生物。因害羞一直未行诊治,赘生物逐渐增多。2年前赘生物生长速度变快增大,相互融合成块,常有破溃、流黄水、恶臭味。但平时大、小便尚能排出,月经正常。半个月前因疼痛在当地医院就诊,诊为尖锐湿疣,给予淋必治、干扰素、先锋霉素治疗5d,疼痛减轻,转入我院。患病以来无发热、头疼、恶心、呕吐、腹痛、腹泻等症状。既往身体健康,否认肝炎、结核病史。4年前曾交一男友,并发生性关系。自述男友生殖器上也曾有过刺状皮损。家族中无肿瘤患者。入院体检:体温36.5℃、脉搏72次、呼吸18次、血压1 相似文献
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我科自 1997年 10月~ 1998年 6月 ,用派瑞松 (原名复方达克宁霜 ,西安杨森制药有限公司生产 )治疗湿疹 70例 ,现将结果报告如下。病例与方法病例 70例湿疹患者均来自门诊 ,有典型症状 ,皮损比较局限。治疗前 1周内未曾内用和外用皮质激素及抗组胺类药物。男 2 8例 ,女 42例。年龄 3 .5月~ 67岁 ,平均 2 5 .96岁。病程 3天~ 4.5年 ,平均 8.4月。发病部位 :头面部 2 1例 ,上肢5例 ,手 7例 ,背部 3例 ,小腿 2 5例 ,足 7例 ,阴囊 2例。分型 : 河北医科大学二院皮肤科 ,石家庄市 ,0 50 0 0 0亚急性 67例 ,慢性 3例。方法 每日早晚外用派瑞… 相似文献
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玫瑰糠疹表皮内血管细胞黏附分子1和细胞间黏附分子1的表达 总被引:6,自引:0,他引:6
目的:研究血管细胞黏附分子(1VCAM-l)和细胞间黏附分子(1ICAM-1)在玫瑰糠疹发病中的作用。方法:采用链酶卵白素-过氧化物酶法检测表皮内VCAM-l、ICAM-1的表达。结果:VCAM-1在玫瑰糠疹皮损表皮基底层、棘层表达高于皮损周围正常皮肤及正常人皮肤,在皮损周围正常皮肤棘层表达高于正常人皮肤。ICAM-1在皮损、皮损周围正常皮肤基底层的表达高于正常人皮肤,在皮损棘层的表达高于皮损周围正常皮肤及正常人皮肤。结论:玫瑰糠疹表皮VCAM-1、ICAM-1的高表达可能与玫瑰糠疹的发病机制有关。 相似文献
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BACKGROUND: Studies have found that sodium arsenite can cause the malignant transformation and tumorigenicity of HaCaT cells, but whether low concentrations of sodium arsenite can cause the malignant transformation is rarely reported.
OBJECTIVE: To study the effect of sodium arsenite on the malignant transformation of human immortalized keratinocyte cell lines.
METHODS: HaCaT cells were treated with different concentrations of sodium arsenite. MTT assay was used to determine the effect of sodium arsenite on HaCaT cell morphology and proliferation, flow cytometry used to detect the effect of sodium arsenite on HaCaT cell cycle, and soft agar colony formation experiments assay used to determine the effect of sodium arsenite on HaCaT cell colony formation capacity.
RESULTS AND CONCLUSION: HaCaT cells grew well when the concentration of sodium arsenite was 5 mol/L, but the cell growth was inhibited under intervention with 10 and 50 mol/L sodium arsenite. HaCaT cells treated with 0.1 mol/L sodium arsenite were passaged to the 20th generation, and cell morphology had no notable changes; cells at passage 25 exhibited enlarged size and multiple nucleoli, which had a continued proliferation trend. Compared with the primarily cultured cells, 0.1 mol/L sodium arsenite-treated HaCaT cells at passages 15 and 25 had an increased proportion at S phase and G2/M phase, with strengthened proliferation ability and increased colony-forming efficiency, and moreover, the proliferation ability and colony-forming efficiency of passage 25 cells were higher than those of passage 15 cells. These experimental data show that high concentrations of sodium arsenite reduce HaCaT cell viability, and low concentrations of sodium sulfite have a certain influence on the morphology, cell cycle, proliferation ability and colony-forming efficiency of HaCaT cells, and moreover, the proliferation ability and colony-forming efficiency of human immortalized keratinocytes will be strengthened with the increase of passage. 相似文献
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