师生共建虚拟仿真实验的探索与实践

虚拟仿真实验可以激发学生的学习自主性。此项目以师生共建科研团队的方式,引导学生自主获取学习资源,依托福建医科大学已有资源优势,聚焦生物药物的生产,以药品生产质量管理规范(Good Manufacturing Practices,GMP)为基础建设虚拟仿真实验平台。此平台可供学生课前预习学习视频,课上结合教师讲解的重难点,完成虚拟操作、实训、课后习题巩固、操作考核等模块。本项目可实现重点培养本科生创新精神、学习自主性和团结协作的能力的目的,为各高校变革人才培育方式提供借鉴。     

系统性红斑狼疮与妊娠

系统性红斑狼疮(SLE)是一种全身性自身免疫病,多发生于育龄期女性。SLE与妊娠之间相互作用,一方面,妊娠期免疫状态及生理变化可导致狼疮复发,另一方面,SLE患者在妊娠过程中疾病复发,发生狼疮肾炎加重、高血压、子痫、胎儿丢失、早产儿及新生儿狼疮等的机率明显升高。尽管风湿免疫科医师对狼疮患者的妊娠较为重视,但母亲和胎儿的死亡率仍居高不下,因此,进一步增进对狼疮与妊娠的认识、选择合适的妊娠时机、应用安全的药物保持病情尤为重要。     

骨质疏松治疗新靶点

随着社会的进步,生活水平的提高及人口老龄化时代的到来,骨质疏松发病率逐年增长并逐渐成为影响人们生活质量的慢性疾病之一。传统的骨质疏松治疗药物目前尚不能降低此疾病骨折的发生风险、不能有效提高骨密度及减轻疼痛等不适。如今,随着人们对骨质疏松发病机制的进一步探讨,参与骨质疏松发病的OPG/RANKL/RANK、Wnt/β连环蛋白信号通路、Sclerostin、CathepsinK等信号分子逐步发现,并有望成为骨质疏松治疗的新靶点。     

抗磷脂抗体相关性复发性流产的诊治:附75例抗磷脂综合征患者妊娠期用药和结局分析

Recurrent spontaneous abortion is one of the common complications in women of childbearing age during pregnancy. The immune factor accounts for a large proportion of many causes. Antiphospholipid antibody syndrome is the most common type of acquired thrombophilia disease. Autoimmune di-seases that cause thrombosis and obstetric complications under the action of antibodies are also the most common type of immune-related recurrent abortion. At present, there is no unified opinion on the treatment of this disease, especially the treatment of immunoglobulins and other drugs like glucocorticoid. Here we reviewed the progress of diagnosis and treatment of antiphospholipid antibody-related recurrent abortions and retrospectively analyzed and summarized the drug regimens and pregnancy outcomes of this disease with pregnancy patients in our hospital. A total of 75 patients were included. According to their clinical manifestations and laboratory results, these patients were basically divided into two categories:classical antiphospholipid syndrome and non-classical antiphospholipid syndrome. The latter was further divided into serum-negative antiphospholipid syndrome and antiphospholipid antibody-related recurrent abortion patients based on their clinical manifestations and antiphospholipid antibody results. The patients were divided into four categories:aspirin + hydroxychloroquine, aspirin + low molecular weight heparin, aspirin + low molecular weight heparin + hydroxychloroquine, aspirin + hydroxychloroquine + low molecular weight heparin + low dose glucocorticoids. Among them, aspirin + hydroxychloroquine + low molecular weight heparin + low-dose glucocorticoid treatment regimen was most commonly used. Most of the patients who received the above different treatment regimens achieved full-term infants, and a small number of patients had adverse pregnancy outcomes, such as premature delivery, placental abruption, eclampsia, and fetal malformation. And adverse pregnancy outcomes also occurred in this group. It might be related to the severity of the disease and the potential adverse effects of maternal fetal. However, further statistical analysis is needed for the risk factors affecting the pregnancy outcome of this part of patients.