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Patients’ intention to consume prescribed and non‐prescribed medicines: A study based on the theory of planned behaviour in selected European countries 下载免费PDF全文
A. Kamekis MA PhD A. Bertsias PhD J. Moschandreas MSc MSc PhD E. Petelos MPH PhD M. Papadakaki MPH PhD V. Tsiantou MSc PhD A. Saridaki MSc E. K. Symvoulakis MD PhD K. Souliotis PhD N. Papadakis MA MA PhD T. Faresj? PhD A. Faresj? PhD L. Martinez MD D. Agius MD MSc MMCFD Y. Uncu PhD T. Sengezer MD G. Samoutis MD PhD J. Vlcek PhD A. Abasaeed PhD B. Merkouris MD C. Lionis MD PhD FRCGP 《Journal of clinical pharmacy and therapeutics》2018,43(1):26-35
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Material practices for meaningful engagement: An analysis of participatory learning and action research techniques for data generation and analysis in a health research partnership 下载免费PDF全文
Mary O'Reilly‐de Brún MTh BA Th Tomas de Brún MTh BA Th Catherine A. O'Donnell PhD MPH BSc Maria Papadakaki PhD MPH Aristoula Saridaki MSc Christos Lionis PhD MD Nicola Burns PhD BA Chris Dowrick PhD MD MSc BA Katja Gravenhorst MSc Wolfgang Spiegel MD Chris Van Weel PhD MD Evelyn Van Weel‐Baumgarten PhD MD Maria Van den Muijsenbergh PhD MD Anne MacFarlane PhD MA BA 《Health expectations》2018,21(1):159-170
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Stavros Apostolakis Zacharenia Vlata Konstantina Vogiatzi Elias Krambovitis Demetrios A. Spandidos 《Journal of thrombosis and thrombolysis》2010,29(4):443-448
The potential regulatory effect of angiotensins on circulating mononuclear cell activation and migration has not yet been thoroughly evaluated. Using flow cytometry we assessed the possible effect of angiotensin I and II on the expression of CX3CR1 and a single representative of each major chemokine family (CCR5 and CXCR4) in THP-1 monocytes, Jurcat T lymphocytes and primary monocytes—isolated from healthy donors. Fluorescence intensity and the rate of chemokine-positive cells was measured in naïve cells and cells treated with angiotensin I and II. Neither angiotensin I nor angiotensin II exhibited any effect on fluorescence intensity and the rate of CX3CR1-, CCR5- and CXCR4-positive cells in primary peripheral blood mononuclear cells and Jurkat T cells. However, angiotensin II significantly increased the rate of CX3CR1-positive THP-1 cells. This effect was not attenuated by the pre-incubation of THP-1 cells with the AT-1 receptor blocker losartan, suggesting that this was not an AT-1-mediated effect. Angiotensin I and II had no effect on fluorescence intensity and the rate of CCR5- and CXCR4-positive THP-1 cells. In conclusion, angiotensin II increases the rate of CX3CR1-positive THP-1 cells. By extrapolating this in vitro observation to disease mechanisms, we speculate that angiotensin II induces up-regulation of CX3CR1 and promotes firm adhesion of circulation CX3CR1-positive monocytes on CX3CL1 expressing endothelial cells inducing vascular inflammation and atherogenesis. 相似文献
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The introduction in clinical practice of anti-epidermal growth factor receptor (EGFR) antibodies has improved the clinical
outcome of metastatic colorectal cancer (mCRC) patients. Nevertheless, only 10% of mCRC tumors respond to these treatments,
thus rendering the efforts made to maximize their therapeutic index justified. Although several biomarkers have been identified,
we do not know yet how to administer these drugs in colorectal cancer patients in a “personalized–targeted manner.” With this
review we will try to demonstrate that we need to go beyond the assumption of a binary relationship between one genetic event
and response or resistance to anti-EGFR drugs and that several factors can influence the response to these agents. Therefore,
the introduction in future approaches of a holistic genomic discovery plan instead of an individual and specific identification
of alterations is needed. 相似文献
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Z Saridaki D Papadatos-Pastos M Tzardi D Mavroudis E Bairaktari H Arvanity E Stathopoulos V Georgoulias J Souglakos 《British journal of cancer》2010,102(12):1762-1768
Background:
The significance of BRAF mutations, microsatelite instability (MSI) status and cyclin D1 expression in patients with metastatic colorectal cancer (mCRC) was evaluated.Methods:
Primary tumours from 144 patients treated for mCRC were assessed for BRAF (V600E) mutation, MSI status and cyclin D1. The data were correlated with progression-free survival (PFS) and overall survival (OS).Results:
BRAF mutations were detected in 10 (out of 22, 45%) patients with MSI-H tumours compared with 2 (out of 122, 1.6%) in those with microsatellite stable tumours (P<0.001). The presence of BRAF mutations was correlated with cyclin D1 overexpression (7 out of 26 patients, 58% vs 5 out of 118 patients, 14% P=0.001). Patients with BRAF-mutated primary tumours had a significantly decreased PFS (2.7 vs 9.8 months; P<0.001) and median OS (14 vs 30 months; P<0.001) than patients with wild-type (wt) tumours. Patients with MSI-H and BRAF-mutated tumours experienced significantly lower PFS (3.1 vs 11.4 months; P=0.008) and OS (14.5 vs 35.5 months; P=0.004) than patients with MSI-H and BRAF wt tumours. Similarly, BRAF mutations and cyclin D1 overexpression were correlated with decreased PFS (3.1 vs 8.6 months; P=0.03) and OS (17.8 vs 39.2 months; P=0.01).Conclusion:
BRAF V600E mutations are associated with MSI-H status and cyclin D1 overexpression and characterize a subgroup of patients with poor prognosis. 相似文献9.
The plasma OT increment following stress in rats is sexually dimorphic, females exhibiting greater responses than males. We have investigated the role of neonatal androgen secretion in determining the sex-typical level of response. Castration of male pups either surgically or functionally (GnRH antagonist treatment) within either 2 h or 5 days of birth did not elevate the OT responses of adult males. In contrast, androgenization of female pups (testosterone, 1.25 mg/pup) within 5 days of birth markedly reduced the OT stress responses of adults to a level insignificantly different to males. The results show that neonatal androgens can exert organizational effects on OT regulatory mechanisms. Since neonatal castration was ineffective it would appear that a prenatal defeminization or masculinization event determines OT stress responsiveness in males. 相似文献
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